INT3950

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Context Info
Confidence 0.77
First Reported 1977
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 293
Total Number 296
Disease Relevance 122.28
Pain Relevance 62.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
PGE2 40
microglia 21
chondrocytes 11
neurons 6
macrophages 5
Ptger2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 3621 100.00 Very High Very High Very High
cytokine 608 100.00 Very High Very High Very High
Osteoarthritis 403 100.00 Very High Very High Very High
Calcitonin gene-related peptide 319 100.00 Very High Very High Very High
COX2 311 100.00 Very High Very High Very High
Inflammatory mediators 270 100.00 Very High Very High Very High
metalloproteinase 167 100.00 Very High Very High Very High
Hyperalgesia 105 100.00 Very High Very High Very High
aspirin 170 99.92 Very High Very High Very High
Inflammatory response 826 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 4900 100.00 Very High Very High Very High
Cancer 1274 100.00 Very High Very High Very High
Osteoarthritis 456 100.00 Very High Very High Very High
Hyperalgesia 133 100.00 Very High Very High Very High
Necrosis 104 100.00 Very High Very High Very High
Depression 10 99.78 Very High Very High Very High
Stress 972 99.72 Very High Very High Very High
Inflammatory Pain 19 99.64 Very High Very High Very High
Metastasis 136 99.60 Very High Very High Very High
Fever 1508 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that EP2 and EP3 are expressed in trigeminal neurons (58% and 53% of total neurons, respectively) and are co-expressed in TRPV(1)-positive neurons (64% and 67 % of TRPV(1)-positive neurons, respectively).
Gene_expression (expressed) of EP2 in neurons
1) Confidence 0.77 Published 2008 Journal J. Dent. Res. Section Abstract Doc Link 18296611 Disease Relevance 0.16 Pain Relevance 0.55
EP2 receptor mRNA expression was highest at Day 16 and declined significantly to Day 21.5 and one day postpartum (p < 0.05, Student-Newman-Keuls procedure).
Gene_expression (expression) of EP2 receptor mRNA
2) Confidence 0.74 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9746738 Disease Relevance 0.06 Pain Relevance 0.06
Moreover, most of the cells expressing EP2 or EP3 mRNA were of small to medium diameter (< 30 microm).
Gene_expression (expressing) of EP2
3) Confidence 0.67 Published 2008 Journal J. Dent. Res. Section Abstract Doc Link 18296611 Disease Relevance 0.14 Pain Relevance 0.56
The results showed that EP2 and EP3 are expressed in trigeminal neurons (58% and 53% of total neurons, respectively) and are co-expressed in TRPV(1)-positive neurons (64% and 67 % of TRPV(1)-positive neurons, respectively).
Gene_expression (co-expressed) of EP2 in neurons
4) Confidence 0.67 Published 2008 Journal J. Dent. Res. Section Abstract Doc Link 18296611 Disease Relevance 0.16 Pain Relevance 0.56
Myometrial activity at parturition may change from an active quiescent to an active contractile state in concert with a decline in expression of the relaxatory EP2 receptors and up-regulation of contractile FP receptors.
Gene_expression (expression) of EP2
5) Confidence 0.64 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9746738 Disease Relevance 0 Pain Relevance 0
Changes in expression of contractile FP and relaxatory EP2 receptors in pregnant rat myometrium during late gestation, at labor, and postpartum.
Gene_expression (expression) of EP2 in myometrium
6) Confidence 0.64 Published 1998 Journal Biol. Reprod. Section Title Doc Link 9746738 Disease Relevance 0.09 Pain Relevance 0.09
Only 3 and 6% of macrophages, respectively, expressed EP2 and EP3.
Gene_expression (expressed) of EP2 in macrophages
7) Confidence 0.58 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14552899 Disease Relevance 0.31 Pain Relevance 0.48
A longitudinal section of myometrium was removed, total RNA was extracted, and semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) was performed for glyceraldehyde phosphate dehydrogenase (GAPDH), calponin, EP2, and FP receptor mRNA expression.
Gene_expression (expression) of EP2 in myometrium
8) Confidence 0.57 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9746738 Disease Relevance 0.07 Pain Relevance 0.07
The He-Ne laser therapy reduced the synthesis of PGE2.
Gene_expression (synthesis) of PGE2
9) Confidence 0.56 Published 1996 Journal J Clin Laser Med Surg Section Abstract Doc Link 9456634 Disease Relevance 0.24 Pain Relevance 0.25
These findings strongly suggest the important role of the sympathetic nervous system in the synthesis of PGE2.
Gene_expression (synthesis) of PGE2 in sympathetic nervous system
10) Confidence 0.55 Published 1985 Journal Eur J Anaesthesiol Section Abstract Doc Link 3910429 Disease Relevance 0 Pain Relevance 0.38
We also assessed, by enzyme immunoassay, the effects of the combination on peripheral PGE-2 levels: CAF did not alter the inhibitory effect of ASA on PGE-2 synthesis.
Gene_expression (synthesis) of PGE-2 associated with aspirin
11) Confidence 0.52 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17507271 Disease Relevance 1.09 Pain Relevance 0.63
In the present study, we report a synergistic interaction between acetylsalicylic acid (ASA) and caffeine (CAF) on the inhibition of nociception in a model of peripheral inflammation in rat; on the contrary no interaction have been found on anti-inflammatory effects and peripheral prostaglandin E2 (PGE-2) synthesis inhibition.
Gene_expression (synthesis) of prostaglandin E2 associated with nociception, aspirin and inflammation
12) Confidence 0.52 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17507271 Disease Relevance 0.97 Pain Relevance 0.46
In the present study, we report a synergistic interaction between acetylsalicylic acid (ASA) and caffeine (CAF) on the inhibition of nociception in a model of peripheral inflammation in rat; on the contrary no interaction have been found on anti-inflammatory effects and peripheral prostaglandin E2 (PGE-2) synthesis inhibition.
Gene_expression (synthesis) of PGE-2 associated with nociception, aspirin and inflammation
13) Confidence 0.52 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17507271 Disease Relevance 0.97 Pain Relevance 0.46
Concentrations of PGE-2 and PGF-2 alpha were significantly higher at 48 h when abortion had occurred in all animals (6.5 +/- 2.6 vs. 2.4 +/- 1.7 ng PGE-2/g and 30.4 +/- 8.9 vs. 9.3 +/- 5.6 ng PGF-2 alpha/g).
Gene_expression (Concentrations) of PGE-2 associated with reprotox - general 1
14) Confidence 0.50 Published 1992 Journal J. Reprod. Fertil. Section Abstract Doc Link 1552472 Disease Relevance 0.16 Pain Relevance 0.07
The analysis of the data revealed a statistically significant difference between the levels of the synthesis of PGE2 before treatment (17.69 +/- 2.65 ng mg-1 of dry tissue h-1) and after treatment (13.85 +/- 2.73 ng mg-1 of dry tissue h-1), with p < 0.01 comparing mean values.
Gene_expression (synthesis) of PGE2
15) Confidence 0.49 Published 1996 Journal J Clin Laser Med Surg Section Abstract Doc Link 9456634 Disease Relevance 0.24 Pain Relevance 0.27
This paper reports the effect of helium-neon laser radiation (power of 5 mW and 632.8 nm wave length) on the synthesis of PGE2 in vitro in synovial tissue of biopsy samples of knee joints in patients with chronic rheumatoid arthritis stages II or III.
Gene_expression (synthesis) of PGE2 in knee joints associated with rheumatoid arthritis
16) Confidence 0.49 Published 1996 Journal J Clin Laser Med Surg Section Abstract Doc Link 9456634 Disease Relevance 0.17 Pain Relevance 0.09
-adrenergic agonist isoproterenol increases COX-2 protein and PGE2 synthesis in microglial cells [8].
Gene_expression (synthesis) of PGE2 in microglial cells associated with agonist
17) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0.25 Pain Relevance 0.25
The effect of standard anaesthesia (G-I) and epidural analgesia (G-II) on urinary synthesis of PGE2 was compared in two groups of 12 patients each undergoing orthopaedic surgery.
Gene_expression (synthesis) of PGE2 associated with epidural and analgesia
18) Confidence 0.48 Published 1985 Journal Eur J Anaesthesiol Section Abstract Doc Link 3910429 Disease Relevance 0 Pain Relevance 0.38
The interaction between PGE2 and P2X3 receptors has not been well delineated.
Gene_expression (receptors) of PGE2 in PGE2
19) Confidence 0.47 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2063498 Disease Relevance 0.26 Pain Relevance 0.09
These results are consistent with the pattern of inhibition of AVP-dependent adenosine 3',5'-cyclic monophosphate (cAMP) production in the rat and rabbit CCD in that PGE2 inhibits both transport and cAMP production in the rabbit but not the rat CCD, and clonidine inhibits both transport and cAMP production in the rat but not the rabbit CCD [D.
Gene_expression (production) of PGE2 in PGE2 associated with adenocard and clonidine
20) Confidence 0.43 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1858893 Disease Relevance 0 Pain Relevance 0.53

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