INT39500

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Context Info
Confidence 0.48
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 9.75
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pth) extracellular region (Pth) cellular_component (Pth)
Anatomy Link Frequency
parathyroid 16
femur 2
Pth (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 8 99.60 Very High Very High Very High
anesthesia 7 98.52 Very High Very High Very High
carpal tunnel syndrome 3 92.40 High High
fibrosis 2 90.00 High High
Pain 7 88.40 High High
pain flank 1 50.00 Quite Low
peptic ulcer disease 1 49.00 Quite Low
imagery 3 24.92 Low Low
Inflammation 9 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 36 100.00 Very High Very High Very High
Decapitation 2 99.92 Very High Very High Very High
Metastasis 14 98.90 Very High Very High Very High
Parathyroid Cancer 5 98.08 Very High Very High Very High
Amyloidosis 4 97.60 Very High Very High Very High
Osteitis 6 97.24 Very High Very High Very High
Acid Base Imbalance 68 97.12 Very High Very High Very High
Rickets 4 96.12 Very High Very High Very High
Chronic Renal Failure 73 95.44 Very High Very High Very High
Carcinoma 1 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although it is difficult to diagnose preoperatively, there should be an increased index of suspicion in those hyperparathyroid patients with palpable neck masses, profound hypercalcemia (greater than 14 mg/100 ml), marked increase in the parathyroid hormone level to greater than twice normal, and significant metabolic complications.
Positive_regulation (increased) of Positive_regulation (increase) of parathyroid hormone in parathyroid associated with hypercalcemia
1) Confidence 0.48 Published 1985 Journal Am. J. Surg. Section Abstract Doc Link 3985291 Disease Relevance 1.13 Pain Relevance 0
All four had, and continue to have, markedly elevated levels of parathyroid hormone (PTH).
Positive_regulation (levels) of Positive_regulation (elevated) of parathyroid hormone in parathyroid
2) Confidence 0.46 Published 1996 Journal Am. J. Kidney Dis. Section Abstract Doc Link 8957047 Disease Relevance 0.85 Pain Relevance 0.09
All four had, and continue to have, markedly elevated levels of parathyroid hormone (PTH).
Positive_regulation (elevated) of Positive_regulation (levels) of parathyroid hormone in parathyroid
3) Confidence 0.46 Published 1996 Journal Am. J. Kidney Dis. Section Abstract Doc Link 8957047 Disease Relevance 0.85 Pain Relevance 0.09
On landing, flight animals had increased ionized calcium (P < 0.001), elevated parathyroid hormone levels (P < 0.001), reduced calcitonin levels (P < 0.05), unchanged 1,25(OH)(2)D(3) levels, and elevated skull (P < 0.01) and reduced femur bone mineral density.
Positive_regulation (increased) of Positive_regulation (elevated) of parathyroid hormone in femur
4) Confidence 0.46 Published 2002 Journal J. Appl. Physiol. Section Abstract Doc Link 11744636 Disease Relevance 0.09 Pain Relevance 0.06
These metastases are predominantly blastic (bone-forming) and commonly cause increased serum levels of parathyroid hormone (PTH) as calcium ions are transferred from serum into blastic bone.
Positive_regulation (cause) of Positive_regulation (increased) of PTH in parathyroid associated with metastasis
5) Confidence 0.43 Published 2008 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 18349265 Disease Relevance 1.03 Pain Relevance 0
These metastases are predominantly blastic (bone-forming) and commonly cause increased serum levels of parathyroid hormone (PTH) as calcium ions are transferred from serum into blastic bone.
Positive_regulation (transferred) of Positive_regulation (increased) of PTH in parathyroid associated with metastasis
6) Confidence 0.43 Published 2008 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 18349265 Disease Relevance 1.05 Pain Relevance 0
We conclude that anesthesia induced by pentobarbital, methoxyflurane, or ketamine + xylazine in rats leads to a marked elevation of serum PTH levels that appears to be related to the duration of anesthesia and not due to any measurable fall in serum Ca2+.
Positive_regulation (leads) of Positive_regulation (elevation) of serum PTH associated with anesthesia and ketamine
7) Confidence 0.41 Published 1995 Journal J. Bone Miner. Res. Section Abstract Doc Link 7502700 Disease Relevance 0.09 Pain Relevance 0.46
Elevation of serum PTH induced by pentobarbital or ketamine + xylazine increased with time under anesthesia.
Positive_regulation (induced) of Positive_regulation (Elevation) of serum PTH associated with anesthesia and ketamine
8) Confidence 0.41 Published 1995 Journal J. Bone Miner. Res. Section Abstract Doc Link 7502700 Disease Relevance 0.10 Pain Relevance 0.44
CONCLUSIONS: It is concluded that the diagnosis of hyperparathyroidism can be made with a very high confidence rate by documenting an increased serum PTH level with an increased ionized or total calcium level in pHPT, increased serum PTH level with low or normal calcium level and an underlying renal failure or vitamin D deficiency in sHPT.
Positive_regulation (increased) of Positive_regulation (increased) of serum PTH
9) Confidence 0.33 Published 2005 Journal Clin. Chim. Acta Section Body Doc Link 15698586 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: It is concluded that the diagnosis of hyperparathyroidism can be made with a very high confidence rate by documenting an increased serum PTH level with an increased ionized or total calcium level in pHPT, increased serum PTH level with low or normal calcium level and an underlying renal failure or vitamin D deficiency in sHPT.
Positive_regulation (increased) of Positive_regulation (increased) of serum PTH
10) Confidence 0.33 Published 2005 Journal Clin. Chim. Acta Section Body Doc Link 15698586 Disease Relevance 0 Pain Relevance 0
The actions of the calcium sensing receptor might also be attenuated by a decrease in extracellular pH, perhaps contributing to an increase in PTH levels [38].
Positive_regulation (contributing) of Positive_regulation (increase) of PTH
11) Confidence 0.17 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2991191 Disease Relevance 1.83 Pain Relevance 0.04
Calcitonin administration caused a mean increase in parathyroid hormone (PTH) secretion 3.6 +/- 1.5 to 6.5 +/- 1.7 ng/ml; p less than 0.05) after 6 weeks of therapy.
Positive_regulation (caused) of Positive_regulation (increase) of parathyroid hormone in parathyroid
12) Confidence 0.10 Published 1984-1985 Journal Uremia Invest Section Abstract Doc Link 6537690 Disease Relevance 0.75 Pain Relevance 0.09
Mild metabolic acidosis was present in three children, parathyroid hormone activity elevated in two and serum vitamin D activity was increased in nine.
Positive_regulation (increased) of Positive_regulation (elevated) of parathyroid hormone in parathyroid
13) Confidence 0.07 Published 2001 Journal Acta Paediatr. Section Body Doc Link 11440097 Disease Relevance 0.14 Pain Relevance 0
This results in increased synthesis and release of parathyroid hormone (PTH).
Positive_regulation (results) of Positive_regulation (increased) of PTH in parathyroid
14) Confidence 0.06 Published 2008 Journal European Journal of Dentistry Section Body Doc Link PMC2635909 Disease Relevance 1.85 Pain Relevance 0

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