INT39503

Context Info Confidence 0.47 First Reported 1985 Last Reported 2009 Negated 1 Speculated 0 Reported most in Body Documents 3 Total Number 7 Disease Relevance 0.09 Pain Relevance 1.29

plasma membrane (KCNK3)

Anatomy Link Frequency neuronal 1 ventral 1 KCNK3 (Homo sapiens)

Pain Link Frequency Relevance Heat isoflurane 2 99.42 Dopamine 270 99.30 halothane 2 97.96 Glutamate 5 95.32 Analgesic 9 93.80 Neurotransmitter 15 84.48 Thalamus 35 78.16 Anterior cingulate 15 69.68 anesthesia 1 59.28 insula 10 49.92

Disease Link Frequency Relevance Heat Cognitive Disorder 40 85.24 Attention Deficit Hyperactivity Disorder 75 5.00 Anxiety Disorder 10 5.00 Disorder Of Lipid Metabolism 10 5.00 Nicotine Addiction 5 5.00 Sleep Disorders 5 5.00 Congenital Anomalies 5 5.00 Metabolic Disorder 5 5.00 Head Trauma 5 5.00 Disease 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, we showed that, similar to the known effect of halothane, sevoflurane and the purified R-(-)- and S-(+)-enantiomers of isoflurane, without stereoselectivity, activated human TASK-1.

Positive_regulation (activated) of TASK associated with isoflurane and halothane

1) Confidence 0.47 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 17699638 Disease Relevance 0 Pain Relevance 0.23

In experiment 2, where cooling was much slower for 5 subjects, no such increase in error rate on the SCRT task was observed.

Neg (no) Positive_regulation (increase) of task

2) Confidence 0.45 Published 1985 Journal Aviat Space Environ Med Section Abstract Doc Link 3985903 Disease Relevance 0 Pain Relevance 0.24

Specifically, we hypothesized that BOLD signals would be positively correlated with DAT (the lower the DAT the lower the activation in task specific regions and the higher the deactivation in the DMN).

Positive_regulation (activation) of task

3) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0 Pain Relevance 0.22

Therefore we predicted that, by decreasing non-task related activity, DA stimulation would result in lower activation of task specific regions (increasing efficiency) and higher deactivation in regions of the DMN, which is deactivated by the task.

Positive_regulation (activation) of task associated with dopamine

4) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0 Pain Relevance 0.21

Since DMN regions are deactivated during the VA task, a positive correlation between DAT and BOLD signals in these regions reflects less deactivation with higher DAT availability (e.g. a negative correlation with deactivation).

Positive_regulation (deactivated) of task

5) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0 Pain Relevance 0.14

Since the ventral precuneus is an area that deactivates during the VA task and is part of the DMN, increased deactivation might reflect that subjects with low DAT deactivated this region and that this effect was greater with increasing attentional load.

Positive_regulation (deactivates) of task in ventral

6) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0.09 Pain Relevance 0.03

This effect in neuronal firing is believed to improve signal-to-noise for the detection of task specific neuronal activation in electrophysiological studies [52].

Positive_regulation (activation) of task in neuronal

7) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0 Pain Relevance 0.22

General Comments

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