INT39503

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Context Info
Confidence 0.47
First Reported 1985
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 0.09
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNK3)
Anatomy Link Frequency
neuronal 1
ventral 1
KCNK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
isoflurane 2 99.42 Very High Very High Very High
Dopamine 270 99.30 Very High Very High Very High
halothane 2 97.96 Very High Very High Very High
Glutamate 5 95.32 Very High Very High Very High
Analgesic 9 93.80 High High
Neurotransmitter 15 84.48 Quite High
Thalamus 35 78.16 Quite High
Anterior cingulate 15 69.68 Quite High
anesthesia 1 59.28 Quite High
insula 10 49.92 Quite Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 40 85.24 High High
Attention Deficit Hyperactivity Disorder 75 5.00 Very Low Very Low Very Low
Anxiety Disorder 10 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 10 5.00 Very Low Very Low Very Low
Nicotine Addiction 5 5.00 Very Low Very Low Very Low
Sleep Disorders 5 5.00 Very Low Very Low Very Low
Congenital Anomalies 5 5.00 Very Low Very Low Very Low
Metabolic Disorder 5 5.00 Very Low Very Low Very Low
Head Trauma 5 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, we showed that, similar to the known effect of halothane, sevoflurane and the purified R-(-)- and S-(+)-enantiomers of isoflurane, without stereoselectivity, activated human TASK-1.
Positive_regulation (activated) of TASK associated with isoflurane and halothane
1) Confidence 0.47 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 17699638 Disease Relevance 0 Pain Relevance 0.23
In experiment 2, where cooling was much slower for 5 subjects, no such increase in error rate on the SCRT task was observed.
Neg (no) Positive_regulation (increase) of task
2) Confidence 0.45 Published 1985 Journal Aviat Space Environ Med Section Abstract Doc Link 3985903 Disease Relevance 0 Pain Relevance 0.24
Specifically, we hypothesized that BOLD signals would be positively correlated with DAT (the lower the DAT the lower the activation in task specific regions and the higher the deactivation in the DMN).
Positive_regulation (activation) of task
3) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0 Pain Relevance 0.22
Therefore we predicted that, by decreasing non-task related activity, DA stimulation would result in lower activation of task specific regions (increasing efficiency) and higher deactivation in regions of the DMN, which is deactivated by the task.
Positive_regulation (activation) of task associated with dopamine
4) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0 Pain Relevance 0.21
Since DMN regions are deactivated during the VA task, a positive correlation between DAT and BOLD signals in these regions reflects less deactivation with higher DAT availability (e.g. a negative correlation with deactivation).
Positive_regulation (deactivated) of task
5) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0 Pain Relevance 0.14
Since the ventral precuneus is an area that deactivates during the VA task and is part of the DMN, increased deactivation might reflect that subjects with low DAT deactivated this region and that this effect was greater with increasing attentional load.
Positive_regulation (deactivates) of task in ventral
6) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0.09 Pain Relevance 0.03
This effect in neuronal firing is believed to improve signal-to-noise for the detection of task specific neuronal activation in electrophysiological studies [52].
Positive_regulation (activation) of task in neuronal
7) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0 Pain Relevance 0.22

General Comments

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