INT39507

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Context Info
Confidence 0.68
First Reported 1985
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 37
Total Number 43
Disease Relevance 12.47
Pain Relevance 14.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (TXNRD1) small molecule metabolic process (TXNRD1) cytoplasm (TXNRD1)
cytosol (TXNRD1) signal transduction (TXNRD1) oxidoreductase activity (TXNRD1)
Anatomy Link Frequency
muscle 10
limb 4
TrA 3
proximal 2
articular cartilage 1
TXNRD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
nociceptor 192 100.00 Very High Very High Very High
c fibre 174 100.00 Very High Very High Very High
Myofascial pain syndrome 8 100.00 Very High Very High Very High
Pain 344 99.92 Very High Very High Very High
headache 13 99.68 Very High Very High Very High
qutenza 198 99.50 Very High Very High Very High
backache 89 99.10 Very High Very High Very High
Chronic low back pain 43 99.08 Very High Very High Very High
lidocaine 13 99.06 Very High Very High Very High
Morphine 7 98.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Tricuspid Valve Insufficiency 58 100.00 Very High Very High Very High
Myofascial Pain Syndromes 8 100.00 Very High Very High Very High
Pain 314 99.92 Very High Very High Very High
Headache 14 99.68 Very High Very High Very High
Low Back Pain 133 99.10 Very High Very High Very High
Referred Pain 4 98.08 Very High Very High Very High
Mitral Valve Insufficiency 104 98.00 Very High Very High Very High
INFLAMMATION 38 97.00 Very High Very High Very High
Aortic Valve Insufficiency 88 96.96 Very High Very High Very High
Rheumatoid Arthritis 4 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND AND OBJECTIVE: The number of neurological second opinions (SO) and tertiary referrals (TR) is increasing.
Positive_regulation (increasing) of TR
1) Confidence 0.68 Published 2008 Journal J. Neurol. Section Abstract Doc Link 18825440 Disease Relevance 0 Pain Relevance 0
This study has demonstrated a viable surface EMG method to evaluate the feed-forward activation of TrA/IO prior to rapid limb movement.
Positive_regulation (activation) of TrA in limb
2) Confidence 0.48 Published 2003 Journal J Electromyogr Kinesiol Section Abstract Doc Link 12932422 Disease Relevance 0.06 Pain Relevance 0.13
The lack of feed-forward activation for TrA has been demonstrated in subjects with low back pain.
Positive_regulation (activation) of TrA in TrA associated with low back pain and backache
3) Confidence 0.48 Published 2003 Journal J Electromyogr Kinesiol Section Abstract Doc Link 12932422 Disease Relevance 0.10 Pain Relevance 0.10
BACKGROUND: Ultrasound imaging is reportedly useful for measuring and training patients to preferentially activate the TrA muscle.
Positive_regulation (activate) of TrA in muscle
4) Confidence 0.48 Published 2005 Journal J Orthop Sports Phys Ther Section Body Doc Link 16001906 Disease Relevance 0.08 Pain Relevance 0
However, across movement trials and subjects the activation of TrA was consistently reduced in amplitude or delayed.
Positive_regulation (activation) of TrA in TrA
5) Confidence 0.48 Published 2003 Journal Exp Brain Res Section Abstract Doc Link 12783146 Disease Relevance 0.65 Pain Relevance 0.81
Specifically, the increases in TrA muscle thickness in those with and without lumbopelvic dysfunction were 32.7% and 47.3% greater, respectively, compared to changes in the IO muscle.
Positive_regulation (increases) of TrA in muscle
6) Confidence 0.42 Published 2009 Journal J Orthop Sports Phys Ther Section Body Doc Link 19881003 Disease Relevance 0 Pain Relevance 0
Importantly, this is the first study to demonstrate increasing prevalence of TR associated with greater duration of fenfluramine use.
Positive_regulation (increasing) of TR associated with tricuspid valve insufficiency
7) Confidence 0.39 Published 2008 Journal BMC Med Section Body Doc Link PMC2585088 Disease Relevance 1.31 Pain Relevance 0
Yet, desensitization of polymodal A-nociceptors may have contributed to the reduction of the evoked delta power (ER I of evoked TFR) and N2–P2 amplitude of the LEP whereas sensitization of polymodal C-nociceptors may have contributed to the enhancement of the TR III in the total TFR.
Positive_regulation (enhancement) of TR III in nociceptors associated with c fibre and nociceptor
8) Confidence 0.36 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004625 Disease Relevance 0.22 Pain Relevance 1.51
It was also a finding of this study that four asymptomatic subjects did not pre-activate, therefore providing a rationale for future prospective investigations on whether the lack of TrA/IO feed-forward activation is a cause or an effect of low back pain.
Spec (whether) Positive_regulation (activation) of TrA in TrA associated with low back pain and backache
9) Confidence 0.35 Published 2003 Journal J Electromyogr Kinesiol Section Abstract Doc Link 12932422 Disease Relevance 0.10 Pain Relevance 0.10
On lifting the lower extremity, the control group demonstrated a 23.7% and 11.2% increase in TrA and IO muscle thickness, respectively, while those with lumbopelvic pain demonstrated a 6.4% and 5.7% increase in TrA and IO muscle thickness, respectively.
Positive_regulation (increase) of TrA in extremity
10) Confidence 0.34 Published 2009 Journal Arch Phys Med Rehabil Section Body Doc Link 19406295 Disease Relevance 0.06 Pain Relevance 0
On lifting the lower extremity, the control group demonstrated a 23.7% and 11.2% increase in TrA and IO muscle thickness, respectively, while those with lumbopelvic pain demonstrated a 6.4% and 5.7% increase in TrA and IO muscle thickness, respectively.
Positive_regulation (increase) of TrA in extremity
11) Confidence 0.34 Published 2009 Journal Arch Phys Med Rehabil Section Body Doc Link 19406295 Disease Relevance 0.05 Pain Relevance 0
While inhibition of the descending motor command cannot be excluded, it is more likely that the change in recruitment of TrA represents a more complex change in organisation of the postural response.
Positive_regulation (recruitment) of TrA in TrA
12) Confidence 0.34 Published 2001 Journal Exp Brain Res Section Abstract Doc Link 11713638 Disease Relevance 0.36 Pain Relevance 0.36
The abdominal draw-in maneuver was used to volitionally activate the TrA and a series of upper extremity lifting tasks were used to automatically activate the LM.
Positive_regulation (activate) of TrA in upper
13) Confidence 0.32 Published 2008 Journal Man Ther Section Abstract Doc Link 17198763 Disease Relevance 0.32 Pain Relevance 0.71
The objective of the current study was to investigate the validity and reliability of using a surface EMG site to replicate the findings for the feed-forward activation of TrA prior to rapid limb movement.
Positive_regulation (activation) of TrA in limb
14) Confidence 0.32 Published 2003 Journal J Electromyogr Kinesiol Section Abstract Doc Link 12932422 Disease Relevance 0.09 Pain Relevance 0.09
However, the prevalence of moderate or greater TR was increased compared with published prevalence in the general population [23] and was similar to prevalence of MR in our population.
Positive_regulation (increased) of TR associated with tricuspid valve insufficiency and mitral valve insufficiency
15) Confidence 0.32 Published 2008 Journal BMC Med Section Body Doc Link PMC2585088 Disease Relevance 1.46 Pain Relevance 0
Results showed that subjects with LBP showed significantly less shortening of the TrA muscle (P < 0.0001) and greater increases in thickness of the IO muscle (P = 0.002) with the simulated weight-bearing task.
Positive_regulation (increases) of TrA in muscle associated with backache
16) Confidence 0.30 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19015895 Disease Relevance 0.62 Pain Relevance 0.77
BACKGROUND: Although the ADIM has been found to produce a symmetrical change in TrA and IO muscle thickness in healthy subjects, how these muscles are activated in those with unilateral lumbopelvic pain during the ADIM remains unknown.
Positive_regulation (change) of TrA in muscles
17) Confidence 0.30 Published 2009 Journal J Orthop Sports Phys Ther Section Body Doc Link 19881003 Disease Relevance 0 Pain Relevance 0
In the segmental stabilization (SS) group, exercises focused on the TrA and LM muscles according to the protocol proposed by Richardson et al.17,28 In the superficial strengthening (ST) group, exercises focused on the rectus abdominis (RA), abdominus obliquus internus (OI), abdominus obliquus externus (OE), and erector spinae (ES).29
Positive_regulation (focused) of TrA in muscles associated with rheumatoid arthritis
18) Confidence 0.30 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2972594 Disease Relevance 0.35 Pain Relevance 0.20
While 0.05 mg/kg morphine remained without any effect, higher doses produced an increase in the four thresholds (Tr, Tp, Tmr, Tip).
Positive_regulation (increase) of Tr associated with pain and morphine
19) Confidence 0.29 Published 1985 Journal Brain Res. Section Abstract Doc Link 3986554 Disease Relevance 1.29 Pain Relevance 1.59
On average, patients in both groups demonstrated a 2-fold increase in the thickness of the TrA during the ADIM.
Positive_regulation (increase) of TrA
20) Confidence 0.28 Published 2005 Journal J Orthop Sports Phys Ther Section Body Doc Link 16001906 Disease Relevance 0.05 Pain Relevance 0

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