INT39512

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Context Info
Confidence 0.56
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 22
Total Number 22
Disease Relevance 8.18
Pain Relevance 4.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
platelet 4
dorsal 2
leukocyte 1
DRG 1
TRAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 12 100.00 Very High Very High Very High
qutenza 30 99.56 Very High Very High Very High
Action potential 9 98.52 Very High Very High Very High
Pain 32 96.24 Very High Very High Very High
Analgesic 8 95.00 High High
Hippocampus 2 93.76 High High
cerebral cortex 11 92.80 High High
anesthesia 6 89.12 High High
antagonist 18 86.84 High High
Angina 5 76.80 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 21 99.76 Very High Very High Very High
Ganglion Cysts 15 99.40 Very High Very High Very High
Respiratory Syncytial Virus 232 97.56 Very High Very High Very High
Coronary Artery Disease 47 97.56 Very High Very High Very High
Acute Coronary Syndrome 53 96.44 Very High Very High Very High
Pain 27 96.24 Very High Very High Very High
Splenomegaly 5 94.72 High High
Hepatomegaly 5 93.12 High High
Stress 17 91.20 High High
Homocystinuria 4 86.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During the therapy with clodronate, TRAP activity in serum decreased.
Negative_regulation (decreased) of TRAP
1) Confidence 0.56 Published 2009 Journal Clin Exp Obstet Gynecol Section Body Doc Link 20101852 Disease Relevance 0.08 Pain Relevance 0
TRAP levels in splenectomized patients decreased more slowly and had started higher, but the difference was not significant.
Negative_regulation (decreased) of TRAP
2) Confidence 0.44 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.07 Pain Relevance 0
Both acids significantly increased chemiluminescence and TBA-RS and decreased TRAP, indicating a simulation of lipid peroxidation and a reduction of tissue antioxidant potential.
Negative_regulation (decreased) of TRAP
3) Confidence 0.43 Published 2000 Journal Neuroreport Section Abstract Doc Link 10718311 Disease Relevance 0.16 Pain Relevance 0.11
We demonstrated that homocysteine significantly increases TBARS and decreases TRAP, both in a dose-dependent manner, but did not change antioxidant enzymes.
Negative_regulation (decreases) of TRAP
4) Confidence 0.33 Published 2003 Journal Metab Brain Dis Section Abstract Doc Link 12822833 Disease Relevance 1.24 Pain Relevance 0.26
During ERT, clinical abnormality rates decreased (except for neurological involvement) and the biological data improved overall during ERT (increased hemoglobin, leukocyte and platelet levels; decreased chitotriosidase, ACE, TRAP, ferritin and gammaglobulin levels).
Negative_regulation (decreased) of TRAP in platelet
5) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.27 Pain Relevance 0
For patients given full-dose ERT, platelet counts increased slightly faster, ferritin and TRAP decreased faster, but chitotriosidase and ACE declined more slowly.
Negative_regulation (decreased) of TRAP in platelet
6) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.23 Pain Relevance 0
Platelet counts in nonsplenectomized patients were stable before ERT (+190 platelets/year), while chitotriosidase and TRAP decreased slightly, and ferritin and ACE increased slightly.
Negative_regulation (decreased) of TRAP in Platelet
7) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.31 Pain Relevance 0.08
Moreover, in the control (untreated) specimens and in the absence of M-CSF, the TRAP staining level was reduced by 25% compared with the level in the presence of M-CSF.
Negative_regulation (reduced) of TRAP
8) Confidence 0.31 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.08 Pain Relevance 0.03
At all ages (1-4 weeks) TRAP activity was reduced 50-60% in capsaicin-treated DRG.
Negative_regulation (reduced) of TRAP in DRG associated with qutenza
9) Confidence 0.26 Published 1985 Journal Brain Res. Section Abstract Doc Link 3986564 Disease Relevance 0.34 Pain Relevance 0.83
In conclusion, a decrease in TRAP-5b serum levels may reflect the pharmacological activity of pamidronate and seems to predict pain relief and a reduction in analgesic consumption.
Negative_regulation (decrease) of TRAP associated with pain and analgesic
10) Confidence 0.25 Published 2002 Journal Int. J. Biol. Markers Section Abstract Doc Link 12521129 Disease Relevance 0.37 Pain Relevance 0.36
TRAP activity was found to be decreased 38% in the dorsal half of the lumbar spinal cord (L3-L5), decreased 33% in nodose ganglion, and unchanged in superior cervical ganglion of the capsaicin treated animals.
Negative_regulation (decreased) of TRAP in dorsal associated with ganglion cysts, qutenza and spinal cord
11) Confidence 0.22 Published 1985 Journal Brain Res. Section Abstract Doc Link 3986564 Disease Relevance 0.44 Pain Relevance 0.94
TRAP activity was found to be decreased 38% in the dorsal half of the lumbar spinal cord (L3-L5), decreased 33% in nodose ganglion, and unchanged in superior cervical ganglion of the capsaicin treated animals.
Negative_regulation (decreased) of TRAP in dorsal associated with ganglion cysts, qutenza and spinal cord
12) Confidence 0.22 Published 1985 Journal Brain Res. Section Abstract Doc Link 3986564 Disease Relevance 0.42 Pain Relevance 0.93
The TRAP effect was blocked by 4 mg/kg glibenclamide and 4 mg/kg HMR1098 and partially blocked by 3 mg/kg 5HD.
Negative_regulation (blocked) of TRAP
13) Confidence 0.13 Published 2010 Journal Mol. Med. Section Abstract Doc Link 20386871 Disease Relevance 0.59 Pain Relevance 0.22
The TRAP effect was blocked by 4 mg/kg glibenclamide and 4 mg/kg HMR1098 and partially blocked by 3 mg/kg 5HD.
Negative_regulation (blocked) of TRAP
14) Confidence 0.13 Published 2010 Journal Mol. Med. Section Abstract Doc Link 20386871 Disease Relevance 0.60 Pain Relevance 0.23
These effects of TRAP were completely reversed by HMR1098 and partially reversed by 5HD.
Negative_regulation (reversed) of TRAP
15) Confidence 0.13 Published 2010 Journal Mol. Med. Section Abstract Doc Link 20386871 Disease Relevance 0.49 Pain Relevance 0.23
Results showed that proline-treated rats presented a decrease of TRAP (30%) and an increase of chemiluminescence (78%).
Negative_regulation (decrease) of TRAP
16) Confidence 0.11 Published 2003 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 12615086 Disease Relevance 0.28 Pain Relevance 0.17
During ERT, clinical abnormality rates decreased (except for neurological involvement) and the biological data improved overall during ERT (increased hemoglobin, leukocyte and platelet levels; decreased chitotriosidase, ACE, TRAP, ferritin and gammaglobulin levels).
Negative_regulation (decreased) of TRAP in leukocyte
17) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.27 Pain Relevance 0
Furthermore, the presence of proline in the medium increased chemiluminescence, decreased TRAP and the activity of superoxide dismutase at proline concentrations similar to those observed in tissues of hyperprolinemic patients (0.5-1.0mM).
Negative_regulation (decreased) of TRAP
18) Confidence 0.08 Published 2003 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 12615086 Disease Relevance 0.28 Pain Relevance 0.22
We observed that l-histidine provoked an increase of chemiluminescence and a reduction of TRAP at concentrations of 2.5 mM and higher, while TBA-RS measurement, GSH-Px, CAT and SOD activities were not affected.
Negative_regulation (reduction) of TRAP
19) Confidence 0.08 Published 2004 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 15036381 Disease Relevance 0.34 Pain Relevance 0.15
Also, the rhRANKL-induced TRAP activity in media was diminished and the observed reduction was dose-dependent (Fig. 1c).
Negative_regulation (diminished) of TRAP
20) Confidence 0.07 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.36 Pain Relevance 0

General Comments

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