INT39513

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Context Info
Confidence 0.48
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 5.11
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
platelet 4
capsules 1
leukocyte 1
osteoclasts 1
dorsal root ganglia 1
TRAP (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 10 98.80 Very High Very High Very High
ischemia 9 84.28 Quite High
Angina 5 83.52 Quite High
cerebral cortex 4 82.68 Quite High
Spinal cord 4 77.84 Quite High
aspirin 7 77.12 Quite High
dorsal root ganglion 1 75.00 Quite High
anesthesia 1 69.44 Quite High
antagonist 6 58.68 Quite High
beta blocker 1 56.84 Quite High
Disease Link Frequency Relevance Heat
Gauchers Disease 120 99.68 Very High Very High Very High
Malaria 80 99.08 Very High Very High Very High
Acute Coronary Syndrome 58 96.80 Very High Very High Very High
Disease Progression 4 95.20 Very High Very High Very High
Cv Unclassified Under Development 10 94.96 High High
Splenomegaly 4 94.72 High High
Spontaneous Fractures 24 94.08 High High
Stroke 5 94.00 High High
Death 8 93.52 High High
Hepatomegaly 4 93.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: We conclude that the measurement of TRAP is useful in monitoring treatment with bisphosphonate clodronate in patients with bone metastatic breast cancer.


Positive_regulation (measurement) of TRAP
1) Confidence 0.48 Published 2009 Journal Clin Exp Obstet Gynecol Section Body Doc Link 20101852 Disease Relevance 0.08 Pain Relevance 0
In controls, both TRAP and TSAP activities in dorsal root ganglia (DRG) increased during the second postnatal week and remained constant thereafter.
Positive_regulation (increased) of TRAP in dorsal root ganglia
2) Confidence 0.35 Published 1985 Journal Brain Res. Section Abstract Doc Link 3986564 Disease Relevance 0.25 Pain Relevance 0.76
For patients given full-dose ERT, platelet counts increased slightly faster, ferritin and TRAP decreased faster, but chitotriosidase and ACE declined more slowly.
Positive_regulation (increased) of TRAP in platelet
3) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.23 Pain Relevance 0
During ERT, clinical abnormality rates decreased (except for neurological involvement) and the biological data improved overall during ERT (increased hemoglobin, leukocyte and platelet levels; decreased chitotriosidase, ACE, TRAP, ferritin and gammaglobulin levels).
Positive_regulation (increased) of TRAP in platelet
4) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.28 Pain Relevance 0
Several biomarkers (chitotriosidase, ferritin, angiotensin-converting enzyme (ACE) and tartrate-resistant acid phosphatase (TRAP)) are elevated during GD evolution [9-16].
Positive_regulation (elevated) of TRAP associated with gauchers disease
5) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 1.06 Pain Relevance 0.05
No significant changes occurred in ACP or TRAP levels.
Neg (No) Positive_regulation (occurred) of TRAP
6) Confidence 0.34 Published 1999 Journal Transfusion Section Body Doc Link 10220269 Disease Relevance 0.07 Pain Relevance 0
Furthermore, the presence of proline in the medium increased chemiluminescence, decreased TRAP and the activity of superoxide dismutase at proline concentrations similar to those observed in tissues of hyperprolinemic patients (0.5-1.0mM).
Positive_regulation (increased) of TRAP
7) Confidence 0.14 Published 2003 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 12615086 Disease Relevance 0.28 Pain Relevance 0.22
During ERT, clinical abnormality rates decreased (except for neurological involvement) and the biological data improved overall during ERT (increased hemoglobin, leukocyte and platelet levels; decreased chitotriosidase, ACE, TRAP, ferritin and gammaglobulin levels).
Positive_regulation (increased) of TRAP in leukocyte
8) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.28 Pain Relevance 0
TRAP induced platelet-neutrophil conjugate formation is related to in vivo ischemic risk in ACS patients.
Positive_regulation (induced) of TRAP in neutrophil associated with acute coronary syndrome
9) Confidence 0.09 Published 2004 Journal Platelets Section Abstract Doc Link 14985171 Disease Relevance 0.87 Pain Relevance 0.47
No enhancement of platelet reactivity to TRAP and collagen was induced by procedure.
Positive_regulation (induced) of TRAP in platelet
10) Confidence 0.08 Published 2001 Journal Thromb. Haemost. Section Abstract Doc Link 11583308 Disease Relevance 0.23 Pain Relevance 0.16
All capsules with LEC present underwent TRAP evaluation for the presence or absence of telomerase activity.
Positive_regulation (underwent) of TRAP in capsules
11) Confidence 0.07 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0 Pain Relevance 0
Following the report that the isotype distribution of antimalarial antibodies was a critical parameter of malaria immunity [46], various studies confirmed the increase of IgG3 with age, and hence with protection, for many malarial antigens including SIRBC extract, MSP1, MSP2, AMA1, RESA, GLURP, p126-SERP-SERA, EBA 175, TRAP, and Exp1 [28,38,39,45,52,55–62].
Positive_regulation (increase) of TRAP associated with malaria
12) Confidence 0.07 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC2071934 Disease Relevance 0.39 Pain Relevance 0
At the end of the incubation period, the osteoclasts were fixed with citrate/acetone solution and stained for tartrate-resistant acid phosphatase (TRAP) according to the manufacturer's recommendation (Sigma-Aldrich).
Positive_regulation (stained) of TRAP in osteoclasts
13) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483463 Disease Relevance 0 Pain Relevance 0
Thrombin receptor-activating peptide (TRAP)-induced platelet aggregation was performed using the turbidimetry method at those study centres able to perform the test.
Positive_regulation (induced) of TRAP in platelet
14) Confidence 0.03 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2966970 Disease Relevance 1.10 Pain Relevance 0

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