INT39516

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Context Info
Confidence 0.75
First Reported 1985
Last Reported 2011
Negated 2
Speculated 3
Reported most in Body
Documents 81
Total Number 84
Disease Relevance 30.08
Pain Relevance 6.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Alb) enzyme binding (Alb) DNA binding (Alb)
protein complex (Alb) response to stress (Alb) cytoplasm (Alb)
Anatomy Link Frequency
plasma 6
liver 5
hepatocytes 4
stem 3
cerebrospinal fluid 2
Alb (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 14 100.00 Very High Very High Very High
agonist 62 99.48 Very High Very High Very High
Glutamate 16 99.20 Very High Very High Very High
anesthesia 54 99.00 Very High Very High Very High
lidocaine 5 98.96 Very High Very High Very High
isoflurane 25 98.56 Very High Very High Very High
Intracerebroventricular 1 97.72 Very High Very High Very High
dexamethasone 53 97.44 Very High Very High Very High
headache 3 96.96 Very High Very High Very High
Spinal cord 106 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 558 100.00 Very High Very High Very High
Aspergillus Infection 132 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 8 100.00 Very High Very High Very High
Anaerobic Bacterial Infections 5 100.00 Very High Very High Very High
Hyperuricemia 1 100.00 Very High Very High Very High
Hematoma 1 99.88 Very High Very High Very High
Toxicity 50 99.80 Very High Very High Very High
Paraproteinemias 31 99.64 Very High Very High Very High
Cancer 356 99.46 Very High Very High Very High
Multiple Sclerosis 233 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Design and synthesis of a morphine-6-succinyl-bovine serum albumin hapten for vaccine development.
Gene_expression (synthesis) of serum albumin associated with morphine
1) Confidence 0.75 Published 1999 Journal Biotechnol. Appl. Biochem. Section Title Doc Link 10512793 Disease Relevance 0.16 Pain Relevance 0.79
Since serum albumin is synthesized particularly by hepatocytes, the albumin promoter/enhancer is activated during liver development.
Gene_expression (synthesized) of albumin in hepatocytes
2) Confidence 0.71 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 0.20 Pain Relevance 0
Mice were immunized against human serum albumin (HSA), and serum anti-HSA antibody levels were measured (in micrograms per milliliter) using an enzyme-linked immunosorbent assay (ELISA).
Gene_expression (immunized) of serum albumin
3) Confidence 0.67 Published 2003 Journal Phys Ther Section Body Doc Link 12837125 Disease Relevance 0.09 Pain Relevance 0
ES cell-derived hepatocytes expressed liver-specific genes, secreted albumin and metabolized ammonia, lidocaine and diazepam.
Gene_expression (expressed) of albumin in hepatocytes associated with lidocaine
4) Confidence 0.66 Published 2006 Journal Nat. Biotechnol. Section Abstract Doc Link 17086173 Disease Relevance 0.15 Pain Relevance 0.10
Plasma was analysed for the following parameters: total protein, total bilirubin, creatine kinase activity, aspartate aminotransferase activity, cholesterol, creatinine, albumin, alkaline phosphatase activity, gamma-glutamyl transferase activity, triglycerides and glutamate dehydrogenase using a Konelab clinical chemistry analyzer (Thermo Scientific, Waltham, MA).


Gene_expression (activity) of albumin in Plasma associated with glutamate
5) Confidence 0.65 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0 Pain Relevance 0.05
Plasma was analysed for the following parameters: total protein, total bilirubin, creatine kinase activity, aspartate aminotransferase activity, cholesterol, creatinine, albumin, alkaline phosphatase activity, gamma-glutamyl transferase activity, triglycerides and glutamate dehydrogenase using a Konelab clinical chemistry analyzer (Thermo Scientific, Waltham, MA).


Gene_expression (activity) of albumin in Plasma associated with glutamate
6) Confidence 0.65 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0 Pain Relevance 0.05
Plasma was analysed for the following parameters: total protein, total bilirubin, creatine kinase activity, aspartate aminotransferase activity, cholesterol, creatinine, albumin, alkaline phosphatase activity, gamma-glutamyl transferase activity, triglycerides and glutamate dehydrogenase using a Konelab clinical chemistry analyzer (Thermo Scientific, Waltham, MA).


Gene_expression (activity) of albumin in Plasma associated with glutamate
7) Confidence 0.65 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0 Pain Relevance 0.05
The albumin ALB, ameloblastin AMBN and enamelin ENAM genes all map to the same region and are therefore candidate genes for autosomal AI.
Gene_expression (genes) of albumin associated with amelogenesis imperfecta
8) Confidence 0.65 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1853073 Disease Relevance 0.67 Pain Relevance 0
The following factors were analyzed: age, sex, underlying disease (arteriosclerosis obliterans or Buerger's disease), grade of symptoms (Fontaine's classification), presence of diabetes mellitus, the site of distal anastomosis (above or below the knee), vascular graft material (reversed saphenous vein, expanded polytetrafluoroethylene or composite), presence of postoperative hematoma, and levels of serum creatinine and albumin 3 weeks after surgery.
Gene_expression (levels) of albumin 3 in saphenous vein associated with arteriosclerosis obliterans, hematoma, diabetes mellitus and disease
9) Confidence 0.63 Published 1993 Journal J Cardiovasc Surg (Torino) Section Abstract Doc Link 8282744 Disease Relevance 1.36 Pain Relevance 0.33
Serial sections, including anterior segment defects in the eyes of Alb-hßigh3 transgenic mice, were cut at 4 ?
Gene_expression (eyes) of Alb in eyes associated with targeted disruption
10) Confidence 0.61 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 0.24 Pain Relevance 0.09
Serial sections, including anterior segment defects in the eyes of Alb-hßigh3 transgenic mice, were cut at 4 ?
Gene_expression (-) of Alb in eyes associated with targeted disruption
11) Confidence 0.61 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 0.24 Pain Relevance 0.09
The host liver of a mouseAlb-uPA/SCID is congenitally damaged owing to uPA overproduction, low blood levels of Alb, and significantly high levels of alanine aminotransferase (ALT).
Gene_expression (levels) of Alb in liver associated with severe combined immunodeficiency
12) Confidence 0.61 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.18 Pain Relevance 0
ChIP assays of the promoter regions of three constitutively expressed genes, Gapdh, Mapt (tau), and Eno2 (neuron specific enolase), were used as positive controls, and the results were normalized to negative control assays from the promoter region of the Alb1 (albumin) gene, which is not expressed in the nervous system.
Neg (not) Gene_expression (expressed) of albumin in nervous system
13) Confidence 0.58 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.50 Pain Relevance 0.20
Approximately 70% of differentiated embryonic stem (ES) cells express albumin and can be recovered by albumin promoter-based cell sorting.
Gene_expression (express) of albumin in stem
14) Confidence 0.56 Published 2007 Journal Nat Protoc Section Abstract Doc Link 17406596 Disease Relevance 0 Pain Relevance 0.18
The sorted cells produce albumin in culture and metabolize ammonia, lidocaine and diazepam at approximately two-thirds the rate of primary mouse hepatocytes.
Gene_expression (produce) of albumin in hepatocytes associated with lidocaine
15) Confidence 0.56 Published 2007 Journal Nat Protoc Section Abstract Doc Link 17406596 Disease Relevance 0 Pain Relevance 0.19
ChIP assays of the promoter regions of three constitutively expressed genes, Gapdh, Mapt (tau), and Eno2 (neuron specific enolase), were used as positive controls, and the results were normalized to negative control assays from the promoter region of the Alb1 (albumin) gene, which is not expressed in the nervous system.
Neg (not) Gene_expression (expressed) of Alb1 in nervous system
16) Confidence 0.56 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.50 Pain Relevance 0.20
ALP has been shown to be a significant independent factor for advanced pancreatic cancer18 and that a 1.8-fold increase of ALP was associated with poor prognosis in a veterans’ cohort, independently of tumor stage.19 Serum albumin was strongly correlated with survival in our multivariable model; this is consistent with the report of Schnelldorfer et al who found that preoperative low albumin was a negative predictor of survival in patients with pancreatic adenocarcinoma undergoing a Whipple procedure; however they failed to prove its independent prognostic value.3
Gene_expression (preoperative) of albumin associated with adenocarcinoma and cancer
17) Confidence 0.55 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2865167 Disease Relevance 0.34 Pain Relevance 0
High levels of ALP (HR: 1.68, 95% CI: 1.09–2.59, p = 0.019), low levels of albumin (HR: 2.17, 95% CI: 1.27–3.69, p = 0.004) and CA 19-9 ?
Gene_expression (levels) of albumin
18) Confidence 0.55 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2865167 Disease Relevance 0.69 Pain Relevance 0
ALP has been shown to be a significant independent factor for advanced pancreatic cancer18 and that a 1.8-fold increase of ALP was associated with poor prognosis in a veterans’ cohort, independently of tumor stage.19 Serum albumin was strongly correlated with survival in our multivariable model; this is consistent with the report of Schnelldorfer et al who found that preoperative low albumin was a negative predictor of survival in patients with pancreatic adenocarcinoma undergoing a Whipple procedure; however they failed to prove its independent prognostic value.3
Gene_expression (low) of albumin associated with adenocarcinoma and cancer
19) Confidence 0.55 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2865167 Disease Relevance 0.34 Pain Relevance 0
In conclusion, we developed an accurate multivariable prognostic model for resectable pancreatic ductal adenocarcinomas, incorporating age, tumor differentiation and size, preoperative CA 19-9, serum albumin and alkaline phosphatase.
Gene_expression (preoperative) of serum albumin associated with adenocarcinoma and cancer
20) Confidence 0.55 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2865167 Disease Relevance 0.46 Pain Relevance 0

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