INT39518

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Context Info
Confidence 0.09
First Reported 1985
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 66
Total Number 68
Disease Relevance 37.54
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 4
visceral 1
superior 1
B-cell 1
arm 1
HBN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 32 98.20 Very High Very High Very High
fifth nerve 3 97.80 Very High Very High Very High
Pain 36 93.72 High High
fluoxetine 10 93.24 High High
tolerance 31 90.00 High High
antidepressant 149 87.68 High High
cytokine 13 87.04 High High
headache 18 85.04 High High
dysesthesia 1 84.56 Quite High
Causalgia 1 83.88 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 3145 99.98 Very High Very High Very High
Weight Loss 143 99.80 Very High Very High Very High
Weight Gain 364 98.88 Very High Very High Very High
Hypoglycemia 815 98.40 Very High Very High Very High
Birth Weight 54 98.28 Very High Very High Very High
Depression 34 98.20 Very High Very High Very High
Body Weight 175 98.08 Very High Very High Very High
Reprotox - General 2 136 98.06 Very High Very High Very High
Disorder Of Lipid Metabolism 101 97.92 Very High Very High Very High
Impaired Glucose Tolerance 19 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Psychological interventions to improve outcomes in diabetes have been systematically reviewed by a number of different authors, [14-16], with pooled trial results suggesting psychological interventions in diabetes reduce HbA1c by a clinically significant 1% [17].
Negative_regulation (reduce) of HbA1c associated with diabetes mellitus
1) Confidence 0.09 Published 2007 Journal BMC Fam Pract Section Body Doc Link PMC1919379 Disease Relevance 0.84 Pain Relevance 0
Although our data are 6–7 years old and there has been a decline in mean HbA1c levels during FY2000 through FY2003, the proportion of individuals with HbA1c <7% did not change (Pogach, personal communication).
Negative_regulation (decline) of HbA1c
2) Confidence 0.09 Published 2007 Journal J Gen Intern Med Section Body Doc Link PMC2150612 Disease Relevance 0.85 Pain Relevance 0
In later pregnancy, at 32-36 weeks’ gestation, a further reduction in HbA1c levels was seen in the intervention arm but no further reductions in the control arm—a difference in mean HbA1c levels of 0.6% between groups: 5.8% (SD 0.6) in intervention arm compared with 6.4% (SD 0.7) in control arm (P=0.007).


Negative_regulation (reduction) of HbA1c in arm
3) Confidence 0.05 Published 2008 Journal BMJ : British Medical Journal Section Body Doc Link PMC2563261 Disease Relevance 0.47 Pain Relevance 0.09
Although a numerically greater reduction in HbA1C with aspart did not reach statistical significance, more patients treated with aspart (59.7%) achieved target HbA1C levels compared with patients treated with lispro (43.8%; P < .04).
Negative_regulation (reduction) of HbA1C
4) Confidence 0.04 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC2877202 Disease Relevance 0.33 Pain Relevance 0
The decreases in HbA1C and FPG were higher with glargine compared to OAD therapy (P = .005 and P = .0001, resp.), with no difference in hypoglycaemia incidences.
Negative_regulation (decreases) of HbA1C associated with hypoglycemia
5) Confidence 0.04 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC2877202 Disease Relevance 0.39 Pain Relevance 0
The United Kingdom Prospective Diabetes Study (UKPDS) [4] has shown that a decrease in HbA1C by 1% is associated with 37 and 14% reduction in the risk of microvascular and macrovascular complications, respectively.
Negative_regulation (decrease) of HbA1C associated with diabetes mellitus
6) Confidence 0.04 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC2877202 Disease Relevance 0.49 Pain Relevance 0
Nevertheless, Pickup et al. [52] and Weissberg-Benchell et al. [53], in their meta-analyses including more than 2100 patients, concluded on an overall advantage of CSII over MDI, with a decrease in HbA1C 0.4–0.5% and a corresponding reduction in insulin requirements.
Negative_regulation (decrease) of HbA1C
7) Confidence 0.04 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC2877202 Disease Relevance 0.15 Pain Relevance 0.04
The patient was treated with insulin therapy and his HbA1c level decreased from 10.3% to 6.8% within 7 months.
Negative_regulation (decreased) of HbA1c
8) Confidence 0.04 Published 2006 Journal J. Int. Med. Res. Section Abstract Doc Link 16604832 Disease Relevance 0.66 Pain Relevance 0.59
Colquitt et al. [55] have demonstrated that the use of insulin analogues with a pump results in a modest (0.26%) but significant reduction in HbA1C compared with soluble insulin.
Negative_regulation (reduction) of HbA1C
9) Confidence 0.04 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC2877202 Disease Relevance 0.17 Pain Relevance 0.04
Additional benefits on intention to treat analysis were a reduction in HbA1c levels in the third trimester and reduced birth weight and risk of macrosomia.
Negative_regulation (reduction) of HbA1c associated with birth weight
10) Confidence 0.03 Published 2008 Journal BMJ : British Medical Journal Section Body Doc Link PMC2563261 Disease Relevance 0.98 Pain Relevance 0
After the study period, the treatment groups showed a trend towards a better glycaemic control expressed as a decrease in HbA1C.
Negative_regulation (decrease) of HbA1C
11) Confidence 0.03 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2668653 Disease Relevance 0.93 Pain Relevance 0.38
The increased risk of hypoglycaemic events remains a major disadvantage of insulin therapy, preventing physicians from applying even more aggressive dosage schemes to lower HbA1C levels.
Negative_regulation (lower) of HbA1C
12) Confidence 0.03 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC2877202 Disease Relevance 0.34 Pain Relevance 0
Pickup et al. [52] in his meta-analysis assessed CSII versus MDI therapy via the evaluation of 12 randomized, controlled trials and showed a reduction of 0.44 in HbA1C (confidence interval: 0.20–0.69) in patients using CSII.
Negative_regulation (reduction) of HbA1C
13) Confidence 0.03 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC2877202 Disease Relevance 0 Pain Relevance 0
In a review of 49 randomized clinical studies comparing analogues with regular human insulin in type 1 diabetic patients, a mean difference in HbA1C of ?
Negative_regulation (difference) of HbA1C associated with diabetes mellitus
14) Confidence 0.03 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC2877202 Disease Relevance 0.39 Pain Relevance 0
Analyses adjusting for age yielded approximately the same increase in the relative risk of a crash for each 1% reduction in HbA1c (odds ratio?
Negative_regulation (reduction) of HbA1c
15) Confidence 0.03 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2780354 Disease Relevance 0.23 Pain Relevance 0
0.019), equal to a 26% increase in the relative risk of a crash for each 1% reduction in HbA1c (odds ratio?
Negative_regulation (reduction) of HbA1c
16) Confidence 0.03 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2780354 Disease Relevance 0.43 Pain Relevance 0
There is evidence that recovery from depression improves glycaemic control, not by inducing severe hypoglycaemic reactions but by slight decreases in HbA1C.
Neg (not) Negative_regulation (decreases) of HbA1C associated with depression
17) Confidence 0.02 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2668653 Disease Relevance 1.11 Pain Relevance 0.44
Analyses adjusting for both age, gender, and each separate complication also yielded about a 25% increase in the risk of a crash for each 1% reduction in HbA1c (odds ratio range 1.20–1.30).
Negative_regulation (reduction) of HbA1c
18) Confidence 0.02 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2780354 Disease Relevance 0.33 Pain Relevance 0
She was given a trial of insulin lispro with immediate and dramatic effects, lowering her HbA1c from 14.6 to 5.1% in 7 months with a decrease in insulin requirements of 1600-100 U per day.
Negative_regulation (lowering) of HbA1c
19) Confidence 0.02 Published 1998 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 9829349 Disease Relevance 1.32 Pain Relevance 0.17
A rise in glycohemoglobin (HbA1C) statisticaly significant was noted, as a sign of slight glucose intolerance, but in no case was there a diabetic pattern.
Negative_regulation (rise) of HbA1C associated with diabetes mellitus and impaired glucose tolerance
20) Confidence 0.02 Published 1985 Journal Clin Exp Obstet Gynecol Section Abstract Doc Link 3987021 Disease Relevance 0.76 Pain Relevance 0.07

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