INT39519

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Context Info
Confidence 0.69
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.78
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PRSS1) extracellular space (PRSS1) extracellular region (PRSS1)
Anatomy Link Frequency
pancreas 4
PRSS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spastic colon 55 99.64 Very High Very High Very High
Chronic pancreatitis 10 98.24 Very High Very High Very High
alcohol 2 96.84 Very High Very High Very High
Inflammation 3 83.28 Quite High
Cholecystokinin 1 75.00 Quite High
headache 2 56.48 Quite High
abdominal pain 2 52.08 Quite High
Versed 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 35 99.80 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

54 99.64 Very High Very High Very High
Pancreatitis 58 99.44 Very High Very High Very High
INFLAMMATION 1 83.28 Quite High
Infection 14 78.80 Quite High
Diarrhoea 5 77.52 Quite High
Constipation 3 75.52 Quite High
Disease 8 68.84 Quite High
Biliary Tract Disease 2 67.92 Quite High
Enteritis 2 61.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased interdigestive pancreatic trypsin secretion in alcoholic pancreatic disease.
Positive_regulation (Increased) of Localization (secretion) of trypsin associated with pancreatitis
1) Confidence 0.69 Published 1985 Journal Dig. Dis. Sci. Section Title Doc Link 3987476 Disease Relevance 0.46 Pain Relevance 0.12
Increased interdigestive pancreatic trypsin secretion in alcoholic pancreatic disease.
Positive_regulation (pancreatic) of Localization (secretion) of trypsin associated with pancreatitis
2) Confidence 0.50 Published 1985 Journal Dig. Dis. Sci. Section Title Doc Link 3987476 Disease Relevance 0.46 Pain Relevance 0.12
A recent study showed that cathepsin B is abundantly present in the secretory compartment of the healthy human pancreas and is secreted together with trypsinogen and active trypsin into the pancreatic juice of patients with chronic pancreatitis [8].
Positive_regulation (active) of Localization (secreted) of trypsin in pancreas associated with chronic pancreatitis
3) Confidence 0.49 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC117221 Disease Relevance 0.42 Pain Relevance 0.10
A recent study showed that cathepsin B is abundantly present in the secretory compartment of the healthy human pancreas and is secreted together with trypsinogen and active trypsin into the pancreatic juice of patients with chronic pancreatitis [8].
Positive_regulation (active) of Localization (secreted) of trypsinogen in pancreas associated with chronic pancreatitis
4) Confidence 0.49 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC117221 Disease Relevance 0.42 Pain Relevance 0.10
Augmentation of trypsin secretion was the most pronounced.
Positive_regulation (Augmentation) of Localization (secretion) of trypsin
5) Confidence 0.46 Published 1981 Journal Digestion Section Abstract Doc Link 6260564 Disease Relevance 0.17 Pain Relevance 0.20
Neurological symptoms in IBS patients have traditionally been attributed to psychiatric causes, but a series of studies has identified an organic etiology by demonstrating that colonic biopsies from IBS and IBD patients secrete high levels of a trypsin-like serine protease [29].
Positive_regulation (levels) of Localization (secrete) of trypsin associated with inflammatory bowel disease and spastic colon
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2987810 Disease Relevance 1.12 Pain Relevance 0.88

General Comments

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