INT3952

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 116
Total Number 116
Disease Relevance 72.18
Pain Relevance 18.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ALB) small molecule metabolic process (ALB) enzyme binding (ALB)
DNA binding (ALB) protein complex (ALB) transmembrane transport (ALB)
Anatomy Link Frequency
plasma 10
liver 7
blood 6
urine 2
cerebrospinal fluid 1
ALB (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 14 100.00 Very High Very High Very High
Somatostatin 1 99.86 Very High Very High Very High
imagery 178 99.84 Very High Very High Very High
fluoxetine 6 99.84 Very High Very High Very High
lidocaine 25 99.70 Very High Very High Very High
Paracetamol 22 99.54 Very High Very High Very High
ischemia 52 99.40 Very High Very High Very High
carbamazepine 14 99.22 Very High Very High Very High
Multiple sclerosis 66 99.18 Very High Very High Very High
Inflammation 457 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 68 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 49 100.00 Very High Very High Very High
Anaemia 48 100.00 Very High Very High Very High
Recurrence 44 100.00 Very High Very High Very High
Weight Loss 43 100.00 Very High Very High Very High
Appetite Loss 77 99.96 Very High Very High Very High
Jaundice 17 99.88 Very High Very High Very High
Body Weight 41 99.84 Very High Very High Very High
Cv General 4 Under Development 21 99.84 Very High Very High Very High
Cirrhosis 26 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These observations suggested that in elderly patients, the elevation of free carbamazepine concentrations in the serum caused by reduced non-glycated albumin levels, induces increases in the sensitivity of the pharmacological effects of carbamazepine and the risk of drug interactions.
Negative_regulation (reduced) of albumin associated with carbamazepine
1) Confidence 0.59 Published 1999 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 10528982 Disease Relevance 0.08 Pain Relevance 0.38
The decrease in ionized and total calcium correlated with a decrease in albumin (P < 0.001).
Negative_regulation (decrease) of albumin
2) Confidence 0.59 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10443655 Disease Relevance 0.13 Pain Relevance 0.57
He suggested that as a result of the decreased levels of albumin and the loss of drawing power in the blood there was a leakage of fluid into the tissues, which is very close to the present day theory of hypoproteinaemic oedema.
Negative_regulation (decreased) of albumin in blood associated with edema
3) Confidence 0.57 Published 2005 Journal Medical History. Supplement Section Body Doc Link PMC2632782 Disease Relevance 1.12 Pain Relevance 0
As it is the free fraction of liraglutide that interacts with GLP-1 receptors, it is possible that the pharmacodynamic effect will be enhanced in the setting of reduced circulating albumin concentrations.
Negative_regulation (reduced) of albumin
4) Confidence 0.56 Published 2010 Journal British Journal of Clinical Pharmacology Section Body Doc Link PMC2997321 Disease Relevance 0.34 Pain Relevance 0
On the other hand, a decrease in albumin concentration may result in an increased rate of metabolism of liraglutide by DPP-IV and NEP.
Negative_regulation (decrease) of albumin
5) Confidence 0.56 Published 2010 Journal British Journal of Clinical Pharmacology Section Body Doc Link PMC2997321 Disease Relevance 0.34 Pain Relevance 0
A trend toward increasing cilostazol free fraction with age was observed in the male subjects, which was explained by a decrease in plasma albumin concentration with age.
Negative_regulation (decrease) of albumin in plasma
6) Confidence 0.50 Published 1998 Journal J Clin Pharmacol Section Abstract Doc Link 9549645 Disease Relevance 0.19 Pain Relevance 0.06
Normal concentration of NEFA (300 microEq.l-1) increased the protein binding ratio of lidocaine, and high concentration of NEFA (1800 microEq.l-1) decreased the ratio on human serum albumin (HSA).
Negative_regulation (decreased) of serum albumin associated with lidocaine
7) Confidence 0.50 Published 1992 Journal Masui Section Abstract Doc Link 1560580 Disease Relevance 0 Pain Relevance 0.73
Nevertheless, as shown in Figure 7, a minor interference of albumin (ranging from 0 to 20 mg/dl) was found on the TAC assay.
Negative_regulation (interference) of albumin
8) Confidence 0.46 Published 2002 Journal BMC Clin Pathol Section Body Doc Link PMC128814 Disease Relevance 0.08 Pain Relevance 0
Albumin- and pH-independent residual ionized calcium decreases of 12.2% in the hepatectomy group, 4.6% in the group of moderately severe and minor cases under general anesthesia, and 3.7% in the control group reflected the severity of the surgical/anesthesia procedure.
Neg (independent) Negative_regulation (decreases) of Albumin associated with anesthesia
9) Confidence 0.43 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10443655 Disease Relevance 0.07 Pain Relevance 0.64
In Canada, hydroxyethyl starch 264/0.45 (HES 264/0.45; molar weight 264 kDa, molar substitution 0.45) has largely replaced albumin as the colloidal fluid of choice for perioperative intravascular volume expansion.
Negative_regulation (replaced) of albumin in molar
10) Confidence 0.43 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15920225 Disease Relevance 0 Pain Relevance 0.06
Binding studies were also performed using both purified human serum albumin and human alpha 1-acid glycoprotein (AAG).
Negative_regulation (using) of albumin
11) Confidence 0.43 Published 1993 Journal Ther Drug Monit Section Abstract Doc Link 8249052 Disease Relevance 0 Pain Relevance 0.96
Since this dosing protocol fails to take into account either of patients status (total body weight and renal function) or of surgical and anesthetic consequences (variations of cardiac output and regional blood flows, progressive decrease of plasma albumin concentration) on cefazolin tissular pharmacokinetics, a physiological modeling study was conducted to investigate protocol suitability for liver surgery in six populations: obese (body mass index >34), renal insufficiency (GFR = 10, 30 or 50 ml min(-1)) and high intraoperative blood loss (three times that usually observed during this surgery) and none of these features referred to as controls.
Negative_regulation (decrease) of albumin in liver associated with pressure volume 2 under development, body weight, renal insufficiency and obesity
12) Confidence 0.43 Published 2005 Journal J Pharmacokinet Pharmacodyn Section Abstract Doc Link 16175313 Disease Relevance 0.65 Pain Relevance 0.13
Pulmonary blood flow distribution was studied by scintillation scanning of the lungs after the infusion of iodine- 131-labeled macroaggregates of human albumin before and after the Mustard operation in 53 patients with transposition of the great arteries.
Negative_regulation (macroaggregates) of albumin in lungs
13) Confidence 0.43 Published 1976 Journal Am. J. Cardiol. Section Abstract Doc Link 937200 Disease Relevance 0.15 Pain Relevance 0
Development of an HPLC assay to study the effect of endogenous and exogenous substances on heat-induced aggregation of human serum albumin.
Negative_regulation (aggregation) of albumin
14) Confidence 0.43 Published 1998 Journal Clin. Chem. Lab. Med. Section Title Doc Link 9589803 Disease Relevance 0.42 Pain Relevance 0.32
We developed a new assay, using gel permeation high performance liquid chromatography, to study the effect of endogenous and exogenous compounds on heat-induced aggregation of human serum albumin in conditions in which protein precipitation does not occur.
Negative_regulation (aggregation) of albumin
15) Confidence 0.43 Published 1998 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 9589803 Disease Relevance 0.40 Pain Relevance 0.33
Another study investigating if pretreatment serum albumin and cholesterol levels were prognostic factors in patients with colorectal carcinomas concluded that a preoperative low level of serum albumin can be an indicator for the malignant potential of the tumor and represents an unfavorable prognosis for patients with colorectal carcinoma [8].
Negative_regulation (level) of serum albumin associated with malignant neoplastic disease, cancer and colon cancer
16) Confidence 0.43 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 1.12 Pain Relevance 0.09
It is necessary then to acknowledge that we ignore how, in Bright's disease, dropsy is connected with the loss of albumin.
Negative_regulation (loss) of albumin associated with edema and disease
17) Confidence 0.42 Published 2005 Journal Medical History. Supplement Section Body Doc Link PMC2630042 Disease Relevance 0.82 Pain Relevance 0
It is certain, on the one hand, that in albuminous nephritis following scarlatina, the patient quickly becomes dropsical, before the loss of albumin has become too considerable, and on the other hand, that in haematuria, endemic in tropical regions, the affected person produces albuminous urine over a period of many years, sometimes throughout their whole life, without becoming dropsical.
Negative_regulation (loss) of albumin in urine associated with nephritis
18) Confidence 0.42 Published 2005 Journal Medical History. Supplement Section Body Doc Link PMC2630042 Disease Relevance 0.67 Pain Relevance 0
Inhibition of heat-induced denaturation of albumin by nonsteroidal antiinflammatory drugs (NSAIDs): pharmacological implications.
Negative_regulation (Inhibition) of albumin associated with inflammation and cinod
19) Confidence 0.42 Published 2001 Journal Arch. Pharm. Res. Section Title Doc Link 11339635 Disease Relevance 0.38 Pain Relevance 0.42
Factor VIII activity and von Willebrand factor level were significantly reduced in the HES 264/0.45 group compared with the albumin group after infusion of 15 mL/kg, 30 mL/kg, and 45 mL/kg (P < 0.05).
Negative_regulation (reduced) of albumin
20) Confidence 0.42 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15920225 Disease Relevance 0 Pain Relevance 0.08

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