INT3954

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Context Info
Confidence 0.52
First Reported 1976
Last Reported 2011
Negated 10
Speculated 1
Reported most in Abstract
Documents 33
Total Number 34
Disease Relevance 15.64
Pain Relevance 9.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fabp6) cytoplasm (Fabp6)
Anatomy Link Frequency
blood 5
anterior 2
plasma 1
arterioles 1
autonomic 1
Fabp6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 51 100.00 Very High Very High Very High
antagonist 15 100.00 Very High Very High Very High
Opioid 13 100.00 Very High Very High Very High
agonist 12 100.00 Very High Very High Very High
opiate 8 100.00 Very High Very High Very High
Intracerebroventricular 4 100.00 Very High Very High Very High
Endogenous opioid 8 99.92 Very High Very High Very High
bradykinin 11 99.50 Very High Very High Very High
Analgesic 10 99.12 Very High Very High Very High
Morphine 6 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 257 100.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 39 100.00 Very High Very High Very High
Hypotension 16 99.90 Very High Very High Very High
Natriuresis 23 99.78 Very High Very High Very High
Diabetes Mellitus 129 99.64 Very High Very High Very High
Nociception 24 99.28 Very High Very High Very High
Pressure And Volume Under Development 9 98.92 Very High Very High Very High
Heart Rate Under Development 4 94.16 High High
Pressure Volume 2 Under Development 14 93.52 High High
Lymphatic System Cancer 2 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A possibility was considered that the renal arterioles are mainly functionally affected in SHR.
Regulation (affected) of SHR in arterioles
1) Confidence 0.52 Published 1976 Journal Jpn. Circ. J. Section Abstract Doc Link 933324 Disease Relevance 0.21 Pain Relevance 0.42
Hemodynamic regulation in SHR: investigation by spectral analysis.
Regulation (regulation) of SHR
2) Confidence 0.52 Published 1987 Journal Am. J. Physiol. Section Title Doc Link 3605364 Disease Relevance 0.40 Pain Relevance 0.10
Acetylcholine and bradykinin enhance hypotension and affect the function of remodeled conduit arteries in SHR and SHR treated with nitric oxide donors.
Regulation (affect) of SHR associated with hypotension and bradykinin
3) Confidence 0.46 Published 2005 Journal Braz. J. Med. Biol. Res. Section Title Doc Link 15933791 Disease Relevance 0.44 Pain Relevance 0.25
Acetylcholine and bradykinin enhance hypotension and affect the function of remodeled conduit arteries in SHR and SHR treated with nitric oxide donors.
Regulation (affect) of SHR associated with hypotension and bradykinin
4) Confidence 0.46 Published 2005 Journal Braz. J. Med. Biol. Res. Section Title Doc Link 15933791 Disease Relevance 0.44 Pain Relevance 0.25
This work is based on the premise that hypertension in the spontaneously hypertensive rat (SHR) is a consequence of an imbalance in autonomic cardiovascular control.
Regulation (consequence) of SHR in autonomic associated with hypertension
5) Confidence 0.44 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3605364 Disease Relevance 0.27 Pain Relevance 0
In contrast, chronic microinfusion of clonidine into the anterior hypothalamic area did not significantly affect any of these measures in 1% salt-fed SHR-S.
Neg (not) Regulation (affect) of SHR-S in anterior associated with clonidine
6) Confidence 0.43 Published 1991 Journal Hypertension Section Abstract Doc Link 1885231 Disease Relevance 0.36 Pain Relevance 0.57
Intravenous infusion of clonidine at the rate used for the anterior hypothalamic area infusion did not alter any of these measures in 8% salt-fed SHR-S.
Neg (not) Regulation (alter) of SHR-S in anterior associated with clonidine
7) Confidence 0.43 Published 1991 Journal Hypertension Section Abstract Doc Link 1885231 Disease Relevance 0.33 Pain Relevance 0.54
Ca2+ supplementation had no effect on blood pressure (BP) or HR responses to clonidine in control NaCl-resistant SHR (SHR-R) or in normotensive Wistar Kyoto (WKY) rats.
Neg (no) Regulation (effect) of SHR in blood associated with clonidine
8) Confidence 0.38 Published 1989 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2468929 Disease Relevance 0.19 Pain Relevance 0.43
Ca2+ supplementation had no effect on blood pressure (BP) or HR responses to clonidine in control NaCl-resistant SHR (SHR-R) or in normotensive Wistar Kyoto (WKY) rats.
Neg (no) Regulation (effect) of SHR-R in blood associated with clonidine
9) Confidence 0.38 Published 1989 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2468929 Disease Relevance 0.19 Pain Relevance 0.43
Ca2+ supplementation prevented the exaggerated depressor response to clonidine in high NaCl-fed SHR-S, but did not reduce the response in SHR-S on the basal NaCl diet.
Neg (not) Regulation (response) of SHR associated with clonidine
10) Confidence 0.38 Published 1989 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2468929 Disease Relevance 0.19 Pain Relevance 0.43
Controls were NaCl-resistant SHR (SHR-R) and normotensive Wistar-Kyoto (WKY) rats.
Regulation (Controls) of SHR
11) Confidence 0.27 Published 1988 Journal J. Hypertens. Section Abstract Doc Link 2848885 Disease Relevance 0.16 Pain Relevance 0.36
Sch 34826 abolished the NaCl-induced increase in blood pressure 3 h after treatment in 8% NaCl fed SHR-S, but had no effect in SHR-S fed the 1% NaCl diet.
Neg (no) Regulation (effect) of SHR-S in blood associated with pressure and volume under development
12) Confidence 0.27 Published 1992 Journal Am. J. Hypertens. Section Abstract Doc Link 1318053 Disease Relevance 0.48 Pain Relevance 0
However, we did not observe increased responsiveness of the SHR/NCrlCrlj to methamphetamine in both SA and CPP assays.
Regulation (responsiveness) of SHR
13) Confidence 0.19 Published 2010 Journal Behav Brain Funct Section Abstract Doc Link PMC3016305 Disease Relevance 0.85 Pain Relevance 0.08
Alterations in the dopaminergic system in ADHD patients as well as in SHR have been identified [10,11].
Regulation (Alterations) of SHR associated with attention deficit hyperactivity disorder
14) Confidence 0.18 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1802084 Disease Relevance 1.73 Pain Relevance 0.73
The Ca2+ supplementation had no effect on pretreatment MAP or on MAP responses to clonidine in control NaCl-resistant SHR (SHR-R) or Wistar-Kyoto (WKY) rats.
Neg (no) Regulation (effect) of SHR-R associated with clonidine
15) Confidence 0.15 Published 1990 Journal Am. J. Hypertens. Section Abstract Doc Link 2171566 Disease Relevance 0.29 Pain Relevance 0.45
The effect of tibalosine (CP 804 S) on systolic blood pressure and heart rate of unanaesthetized normotensive, spontaneously hypertensive (SHR) and DOCA-salt and Goldblatt hypertensive rats has been examined.
Regulation (effect) of SHR in blood associated with hypertension
16) Confidence 0.13 Published 1984 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6145397 Disease Relevance 0.65 Pain Relevance 0
The pressure-natriuresis relationship was studied in anesthetized, 7- to 9-week-old control spontaneously hypertensive rats (SHR) and in SHR that had been treated with hydralazine (20 mg.kg-1.day-1 in drinking water) starting at 4-5 weeks of age.
Regulation (control) of SHR associated with natriuresis and hypertension
17) Confidence 0.13 Published 1991 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2054731 Disease Relevance 0.35 Pain Relevance 0
The pressure-natriuresis relationship was studied in anesthetized, 7- to 9-week-old control spontaneously hypertensive rats (SHR) and in SHR that had been treated with hydralazine (20 mg.kg-1.day-1 in drinking water) starting at 4-5 weeks of age.
Regulation (control) of SHR associated with natriuresis and hypertension
18) Confidence 0.13 Published 1991 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2054731 Disease Relevance 0.35 Pain Relevance 0
Thus, acute increases in ADM to levels found in pathophysiological conditions have no effect on blood pressure, pressure natriuresis, or renal autoregulation in the SHR.
Regulation (autoregulation) of SHR in blood associated with natriuresis
19) Confidence 0.09 Published 1997 Journal Hypertension Section Abstract Doc Link 9323000 Disease Relevance 0.25 Pain Relevance 0
We next administered formalin (5%; 50 microL) and observed greater nociception during both Phase 1 and Phase 2 in SHR controls than in WKY controls.
Regulation (controls) of SHR associated with nociception and hypertension
20) Confidence 0.09 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15155331 Disease Relevance 1.98 Pain Relevance 1.24

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