INT39553

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Context Info
Confidence 0.75
First Reported 1985
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 50
Total Number 61
Disease Relevance 51.18
Pain Relevance 12.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hmgb1) extracellular region (Hmgb1) cell morphogenesis (Hmgb1)
nucleolus (Hmgb1) chromosome (Hmgb1) nucleus (Hmgb1)
Anatomy Link Frequency
liver 5
macrophage 2
lungs 2
Plasma 1
hepatocytes 1
Hmgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1222 100.00 Very High Very High Very High
Inflammation 1076 100.00 Very High Very High Very High
ischemia 702 99.64 Very High Very High Very High
agonist 110 99.62 Very High Very High Very High
intrathecal 1 99.62 Very High Very High Very High
allodynia 1 99.52 Very High Very High Very High
cva 257 99.16 Very High Very High Very High
Inflammatory response 531 97.04 Very High Very High Very High
chemokine 148 96.64 Very High Very High Very High
imagery 4 95.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1752 100.00 Very High Very High Very High
Hemorrhagic Shock 190 99.96 Very High Very High Very High
Brain Tumor 282 99.84 Very High Very High Very High
Hypothermia 128 99.84 Very High Very High Very High
Stress 220 99.82 Very High Very High Very High
Sepsis 1755 99.64 Very High Very High Very High
Cv Unclassified Under Development 698 99.64 Very High Very High Very High
Adult Respiratory Distress Syndrome 181 99.52 Very High Very High Very High
Neuropathic Pain 1 99.52 Very High Very High Very High
Systemic Inflammatory Response Syndrome 119 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression and purification of recombinant HMGB1
Gene_expression (Expression) of HMGB1
1) Confidence 0.75 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0 Pain Relevance 0.13
Western blot analysis of cell culture supernatants revealed increased levels of HMGB1 following treatment with either Ad-TK (+GCV), radiation, or temozolomide (Figure 8).
Gene_expression (levels) of HMGB1
2) Confidence 0.70 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.73 Pain Relevance 0
HMGB1 is constitutively expressed in many cell types, and a large
         ‘pool’ of preformed HMGB1 is stored in the nucleus as a result of the
         presence of two lysine-rich nuclear localisation sequences (Refs 47, 48). 
Gene_expression (expressed) of HMGB1 in nucleus
3) Confidence 0.69 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.37 Pain Relevance 0.05
In murine models of endotoxaemia and sepsis (induced by CLP), HMGB1 is first detectable
           in the circulation 8 h after the onset of lethal endotoxaemia and sepsis,
           subsequently increasing to plateau levels from 16 to 32 h (Refs 51, 80).
           
Gene_expression (detectable) of HMGB1 associated with sepsis
4) Confidence 0.69 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.47 Pain Relevance 0.19
Tsung observed in a mouse ischemia/reperfusion model that HMGB1 protein expression in the liver increased with time up to 24?
Gene_expression (expression) of HMGB1 in liver associated with ischemia
5) Confidence 0.68 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010695 Disease Relevance 1.00 Pain Relevance 0.33
In mechanical stress groups, HMGB1 was already detected after 0.96?
Gene_expression (detected) of HMGB1 associated with stress
6) Confidence 0.68 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010695 Disease Relevance 1.11 Pain Relevance 0.35
3 kDa calmodulin-binding peptide tag (CBP-HMGB1 fusion protein, 33 kDa) was expressed in E. coli, and purified to remove contaminating endotoxin using polymyxin B column as previously described [7], [29], [30].
Gene_expression (expressed) of HMGB1
7) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0 Pain Relevance 0.05
Although delayed administration of EGCG did not attenuate circulating TNF levels at 52 h after the onset of sepsis (Fig. 6C, left panel), it did significantly attenuate circulating levels of HMGB1 (Fig. 6C, right panel, P<0.05), suggesting that EGCG confers protection against lethal sepsis partly by attenuating systemic HMGB1 accumulation.


Gene_expression (levels) of HMGB1 associated with sepsis
8) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.43 Pain Relevance 0.11
Therefore, we propose that EGCG rescues mice from lethal sepsis partly through inhibiting systemic HMGB1 accumulation, as well as HMGB1-induced release IL-6 and KC.
Gene_expression (accumulation) of HMGB1 associated with sepsis
9) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.96 Pain Relevance 0.09
Furthermore, we show that intrathecal administration of HMGB1 produces mechanical allodynia (lowering of the response threshold to calibrated stimuli).
Gene_expression (produces) of HMGB1 associated with allodynia and intrathecal
10) Confidence 0.64 Published 2003 Journal Cytokine Section Abstract Doc Link 14609567 Disease Relevance 0.55 Pain Relevance 0.55
Figure 9A–9D reveals statistically significant increases (*p < 0.05 versus mock and Ad0) in HMGB1 levels in the supernatants of GL26 (?
Gene_expression (levels) of HMGB1
11) Confidence 0.61 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.71 Pain Relevance 0
Levels of HMGB1 were increased in the serum of mice bearing either GL261 (*, p < 0.05; ?
Gene_expression (Levels) of HMGB1
12) Confidence 0.61 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.99 Pain Relevance 0
This late appearance of circulating HMGB1 precedes and parallels the onset of animal
           lethality from endotoxaemia or sepsis, and distinguishes HMGB1 from TNF and other early
           proinflammatory cytokines (Ref. 96) (Fig. 3). 
Gene_expression (precedes) of HMGB1 associated with sepsis and cytokine
13) Confidence 0.60 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.31 Pain Relevance 0.22
Although HMGB1 appears to be a feasible therapeutic target for
       experimental sepsis (Refs 96, 146, 147), its levels in
       unfractionated crude serum of septic patients did not correlated well with disease severity
       (Refs 148, 149). 
Gene_expression (appears) of HMGB1 associated with disease and sepsis
14) Confidence 0.60 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.23 Pain Relevance 0.42
Furthermore, HMGB1 levels in the low (<100 kDa) serum fraction were
       significantly higher in septic patients who died of sepsis than those who survived (Ref.
         51). 
Gene_expression (levels) of HMGB1 associated with sepsis
15) Confidence 0.60 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.83 Pain Relevance 0.21
Indeed, administration of
         stearoyl LPC significantly attenuated circulating HMGB1 levels (Ref. 47), indicating that stearoyl LPC protects against experimental
         sepsis partly by facilitating elimination of invading pathogens and partly by attenuating
         systemic HMGB1 accumulation (Ref. 130).


Gene_expression (levels) of HMGB1 associated with sepsis
16) Confidence 0.60 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.36 Pain Relevance 0.16
min of warm ischemia of the liver [18], suggesting an active production of HMGB1 in addition to a cell damage-associated release.
Gene_expression (production) of HMGB1 in liver associated with ischemia
17) Confidence 0.59 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010695 Disease Relevance 0.90 Pain Relevance 0.30
Loss of cytoplasmic HMGB1 paralleled the detection in the effluent; supporting the hypothesis HMGB1 was indeed released by damaged hepatocytes.
Gene_expression (supporting) of HMGB1 in hepatocytes
18) Confidence 0.59 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010695 Disease Relevance 0.62 Pain Relevance 0.21
In their study, HMGB1 was undetectable in the systemic circulation before human liver transplantation, and the peak value appeared 10?
Gene_expression (undetectable) of HMGB1 in liver
19) Confidence 0.59 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010695 Disease Relevance 1.03 Pain Relevance 0.33
Interestingly, IL-1Ra treatment had no effects on HMGB-1 levels, which maintained a similar pattern to that seen after LPS injection in the absence of IL-1Ra (Figure 2c).
Gene_expression (levels) of HMGB-1
20) Confidence 0.59 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 0.29 Pain Relevance 0.30

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