INT39564

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Context Info
Confidence 0.42
First Reported 1985
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 50
Total Number 56
Disease Relevance 30.90
Pain Relevance 12.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger2) plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
PGE2 8
follicle 6
kidney 3
macrophages 2
plasma 2
Ptger2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 820 100.00 Very High Very High Very High
agonist 190 100.00 Very High Very High Very High
antagonist 67 100.00 Very High Very High Very High
aspirin 44 99.98 Very High Very High Very High
cINOD 110 99.96 Very High Very High Very High
COX2 175 99.86 Very High Very High Very High
COX-2 inhibitor 98 99.58 Very High Very High Very High
Paracetamol 4 98.64 Very High Very High Very High
Inflammatory response 37 97.96 Very High Very High Very High
dexamethasone 10 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 859 100.00 Very High Very High Very High
Infection 560 100.00 Very High Very High Very High
Hemophilus Infection 356 100.00 Very High Very High Very High
Necrosis 466 99.90 Very High Very High Very High
Rupture 8 99.76 Very High Very High Very High
Pressure And Volume Under Development 74 99.18 Very High Very High Very High
Cancer 253 99.16 Very High Very High Very High
Apoptosis 532 98.96 Very High Very High Very High
Hypercalcemia 9 98.96 Very High Very High Very High
Mycobacterial Infection 769 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding is consistent with previous studies showing that in vitro fertilization rates for oocytes stripped of surrounding cumulus cells were similar between wild type mice and mice lacking EP2 receptor expression [5].
Negative_regulation (lacking) of Neg (lacking) Gene_expression (expression) of EP2 receptor in oocytes
1) Confidence 0.42 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0.07 Pain Relevance 0
Blockade of PGE2 production within the follicle [3,4] or genetic manipulation which disrupts PGE2 production or PGE2 receptor expression [5,6] can prevent ovulation, further highlighting the essential role of receptor-mediated actions of PGE2 in mammalian ovulation.
Negative_regulation (disrupts) of Gene_expression (expression) of PGE2 in follicle
2) Confidence 0.42 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0.10 Pain Relevance 0
Blockade of PGE2 production within the follicle [3,4] or genetic manipulation which disrupts PGE2 production or PGE2 receptor expression [5,6] can prevent ovulation, further highlighting the essential role of receptor-mediated actions of PGE2 in mammalian ovulation.
Negative_regulation (disrupts) of Gene_expression (production) of PGE2 in follicle
3) Confidence 0.36 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0.10 Pain Relevance 0
Blockade of PGE2 production within the follicle [3,4] or genetic manipulation which disrupts PGE2 production or PGE2 receptor expression [5,6] can prevent ovulation, further highlighting the essential role of receptor-mediated actions of PGE2 in mammalian ovulation.
Negative_regulation (Blockade) of Gene_expression (production) of PGE2 in follicle
4) Confidence 0.36 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0.10 Pain Relevance 0
Local application of EP2 or EP4 agonist to inner ears
Negative_regulation (application) of Gene_expression (agonist) of EP2 in inner ears associated with agonist
5) Confidence 0.34 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0 Pain Relevance 0.29
These findings confirmed that EP2 expression was present in the cochlear cells, similar to EP4 [9].


Negative_regulation (present) of Gene_expression (expression) of EP2 in cochlear
6) Confidence 0.34 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.16 Pain Relevance 0.21
To investigate whether induction of necrosis by LXA4 is based on an inhibitory effect of LXA4 on PGE2 synthesis, we determined whether LXA4 blocks synthesis of COX2, thus inhibiting generation of PGE2.
Spec (whether) Negative_regulation (inhibiting) of Gene_expression (generation) of PGE2 associated with necrosis and cox2
7) Confidence 0.26 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.27 Pain Relevance 0.10
In contrast to H37Ra infection, PGE2 production is significantly reduced in H37Rv-infected macrophages.
Negative_regulation (reduced) of Gene_expression (production) of PGE2 in macrophages associated with infection
8) Confidence 0.26 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2585850 Disease Relevance 1.49 Pain Relevance 0.04
, LXA4 acts by down-regulating PGE2 synthesis to induce necrosis.
Negative_regulation (down) of Gene_expression (synthesis) of PGE2 associated with necrosis
9) Confidence 0.26 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.49 Pain Relevance 0.08
necrosis via inhibition of PGE2 production.
Negative_regulation (inhibition) of Gene_expression (production) of PGE2 associated with necrosis
10) Confidence 0.26 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.22 Pain Relevance 0.12
Thus, the induction of LXA4 and the resulting inhibition of PGE2 production contribute to the virulence of Mtb and enhance its capacity to evade killing by the innate immune system.
Negative_regulation (inhibition) of Gene_expression (production) of PGE2 in immune system associated with mycobacterial infection
11) Confidence 0.26 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.33 Pain Relevance 0.03
7 M [reference 53]), abrogated the protective effect of PGE2 on M?
Negative_regulation (abrogated) of Gene_expression (effect) of PGE2
12) Confidence 0.25 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 0.43 Pain Relevance 0
1–2 logs lower PGE2 concentrations than M?
Negative_regulation (lower) of Gene_expression (concentrations) of PGE2
13) Confidence 0.25 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.03 Pain Relevance 0.13
Thus, although temporally regulated dampening of the inflammatory response is generally highly beneficial to the host, our studies uncover a novel scenario wherein LXA4-driven reduction of “proinflammatory” PGE2 synthesis functionally acts as an efficient mechanism used by pathogenic Mtb.
Negative_regulation (reduction) of Gene_expression (synthesis) of PGE2 associated with mycobacterial infection and inflammatory response
14) Confidence 0.25 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.12 Pain Relevance 0.28
Ibuprofen decreased ear swelling at the same time-points as apocynin and inhibited the ex vivo produced PGE2.
Negative_regulation (inhibited) of Gene_expression (produced) of PGE2 in PGE2 associated with pressure and volume under development
15) Confidence 0.18 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16405885 Disease Relevance 0.68 Pain Relevance 0.34
The ex vivo production of PGE2 by LPS-stimulated blood cells was significantly decreased after in vivo apocynin treatment.
Negative_regulation (decreased) of Gene_expression (production) of PGE2 in blood cells
16) Confidence 0.18 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16405885 Disease Relevance 0.69 Pain Relevance 0.28
PGE2 and 6-keto PGF1 alpha productions were markedly decreased by these anti-inflammatory drugs, whereas those of TXB2 and PGF2 alpha were not or were only slightly affected.
Negative_regulation (decreased) of Gene_expression (productions) of PGE2 in PGE2 associated with inflammation and cinod
17) Confidence 0.14 Published 1985 Journal J. Immunol. Section Abstract Doc Link 3998470 Disease Relevance 0.10 Pain Relevance 0.21
This study builds on our initial study, which found that celecoxib 400 mg bid decreased PGE2 levels in NAF and/or plasma in women with newly diagnosed breast cancer and in high risk women [16].
Negative_regulation (decreased) of Gene_expression (levels) of PGE2 in plasma associated with breast cancer
18) Confidence 0.10 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 0.26 Pain Relevance 0.04
The synthesis of mucosal PGE2 was markedly suppressed by 33.4% (P < 0.05) and 41.0% (P < 0.01) on the 1st and 3rd day of ulceration, compared to that in the normal mice.
Negative_regulation (suppressed) of Gene_expression (synthesis) of PGE2
19) Confidence 0.10 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.07 Pain Relevance 0
in the presence/absence of the FP receptor antagonist (AL8810), EP2 receptor antagonist (AH6809), EP4 receptor antagonist (ONOAE2227), PLC inhibitor (U73122), PKA inhibitor (4C3MQ), PKC inhibitor (GF109203x), EGFR kinase inhibitor (AG1478) or ERK1/2 inhibitor (PD98059) for 4 h.
Negative_regulation (inhibitor) of Gene_expression (antagonist) of EP2 receptor associated with antagonist
20) Confidence 0.10 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0 Pain Relevance 0.18

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