INT39565

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Context Info
Confidence 0.75
First Reported 1985
Last Reported 2011
Negated 13
Speculated 8
Reported most in Body
Documents 424
Total Number 432
Disease Relevance 229.28
Pain Relevance 72.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger2) plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
PGE2 24
macrophages 16
oocytes 14
neutrophils 9
lung 7
Ptger2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 4887 100.00 Very High Very High Very High
agonist 1683 100.00 Very High Very High Very High
antagonist 1678 100.00 Very High Very High Very High
cytokine 1363 100.00 Very High Very High Very High
Inflammatory mediators 297 100.00 Very High Very High Very High
addiction 24 100.00 Very High Very High Very High
spinal dorsal horn 14 100.00 Very High Very High Very High
Intracerebroventricular 220 99.98 Very High Very High Very High
Pain 337 99.96 Very High Very High Very High
bradykinin 46 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 5613 100.00 Very High Very High Very High
Sprains And Strains 847 100.00 Very High Very High Very High
Hyperalgesia 180 100.00 Very High Very High Very High
Cancer 3488 99.98 Very High Very High Very High
Infection 2904 99.96 Very High Very High Very High
Pain 371 99.96 Very High Very High Very High
Mycobacterial Infection 2511 99.88 Very High Very High Very High
Hemophilus Infection 2403 99.84 Very High Very High Very High
Breast Cancer 674 99.84 Very High Very High Very High
Malignant Neoplastic Disease 593 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo, cumulus cells surrounding oocytes also express EP2 and EP4 receptors, and cAMP generated within cumulus cells can move to the adjacent oocyte through junctional complexes connecting these cells.
Gene_expression (express) of EP2 in cumulus cells
1) Confidence 0.75 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
Blockade of PGE2 production within the follicle [3,4] or genetic manipulation which disrupts PGE2 production or PGE2 receptor expression [5,6] can prevent ovulation, further highlighting the essential role of receptor-mediated actions of PGE2 in mammalian ovulation.
Gene_expression (expression) of PGE2 in follicle
2) Confidence 0.75 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0.10 Pain Relevance 0
While the present study shows that EP2 and EP4 receptor proteins are expressed by mouse cumulus, further studies will be needed to confirm expression of EP3 receptor proteins.
Gene_expression (expressed) of EP2
3) Confidence 0.75 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
Granulosa cells from monkey periovulatory follicles expressed mRNA for all 4 EP receptors, with EP1, EP2, and EP3 receptor proteins detected by immunofluorescence [8].
Gene_expression (expressed) of EP2 in Granulosa cells
4) Confidence 0.75 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
Cumulus granulosa cells showed EP2 immunofluorescence (Figure 2F), consistent with previous reports of EP2 expression by cumulus cells [10] and serving as a positive control.
Gene_expression (expression) of EP2 in granulosa cells
5) Confidence 0.75 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
The present study confirmed that monkey and mouse cumulus granulosa cells expressed EP2 and EP4 receptor proteins.
Gene_expression (expressed) of EP2 in granulosa cells
6) Confidence 0.75 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
Interestingly, all mouse oocytes expressed EP2 and EP4 proteins, though EP2 mRNA was only detectable in 1 of 3 oocyte samples.
Gene_expression (detectable) of EP2 mRNA in oocyte
7) Confidence 0.75 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0.04
Interestingly, all mouse oocytes expressed EP2 and EP4 proteins, though EP2 mRNA was only detectable in 1 of 3 oocyte samples.
Gene_expression (expressed) of EP2 in oocyte
8) Confidence 0.75 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0.04
Detection of EP2 mRNA in bovine oocytes has been reported [12].
Gene_expression (Detection) of EP2 mRNA in oocytes
9) Confidence 0.75 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0.07 Pain Relevance 0
This investigation demonstrates that PGE2 and PGF2alpha receptor genes are expressed in a temporal and cell-specific manner in the periimplantation mouse uterus.
Gene_expression (expressed) of PGE2 in uterus
10) Confidence 0.68 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9116135 Disease Relevance 0.14 Pain Relevance 0.06
Effect of the EP2-selective Agonist ONO-AE1-259-01 on Physiologic Parameters of Mice Subjected to tMCAO
Gene_expression (Effect) of EP2 associated with agonist
11) Confidence 0.67 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2912268 Disease Relevance 0.15 Pain Relevance 0.05
Blockade of PGE2 production within the follicle [3,4] or genetic manipulation which disrupts PGE2 production or PGE2 receptor expression [5,6] can prevent ovulation, further highlighting the essential role of receptor-mediated actions of PGE2 in mammalian ovulation.
Gene_expression (production) of PGE2 in follicle
12) Confidence 0.65 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0.10 Pain Relevance 0
To date, examination of follicular EP receptor expression has focused on granulosa cells, with both cumulus and mural granulosa cells shown to express multiple types of EP receptors [8,9].
Gene_expression (expression) of EP receptor in granulosa cells
13) Confidence 0.65 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0.08 Pain Relevance 0
Blockade of PGE2 production within the follicle [3,4] or genetic manipulation which disrupts PGE2 production or PGE2 receptor expression [5,6] can prevent ovulation, further highlighting the essential role of receptor-mediated actions of PGE2 in mammalian ovulation.
Gene_expression (production) of PGE2 in follicle
14) Confidence 0.65 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0.10 Pain Relevance 0
Mouse oocyte responses to EP receptor agonists
Gene_expression (agonists) of EP receptor in Mouse associated with agonist
15) Confidence 0.65 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0.14
Monkey oocyte responses to EP receptor agonists
Gene_expression (agonists) of EP receptor in oocyte associated with agonist
16) Confidence 0.65 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0.22
EP3 and EP4 mRNAs were detected by RT-PCR in all mouse oocyte preparations examined (n = 3), and EP2 mRNA was detected in 1 of 3 oocyte preparations.
Gene_expression (detected) of EP2 mRNA in oocyte
17) Confidence 0.65 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0.04
These findings confirmed that EP2 expression was present in the cochlear cells, similar to EP4 [9].


Gene_expression (expression) of EP2 in cochlear
18) Confidence 0.63 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.16 Pain Relevance 0.21
We initially confirmed that EP2 expression occurred in the cochlea and showed a similar pattern to EP4 expression [9].
Gene_expression (expression) of EP2 in cochlea
19) Confidence 0.63 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.25 Pain Relevance 0.23
The expression of EP2 in the cochlea was immunohistochemically examined using normal cochlear specimens (n = 3).
Spec (examined) Gene_expression (expression) of EP2 in cochlea
20) Confidence 0.63 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.14 Pain Relevance 0.26

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