INT39587

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Context Info
Confidence 0.65
First Reported 1985
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 42
Total Number 43
Disease Relevance 31.48
Pain Relevance 11.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CP) oxidoreductase activity (CP) extracellular region (CP)
transmembrane transport (CP)
Anatomy Link Frequency
edge 2
blood 2
body 2
Plasma 1
dorsal 1
CP (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 385 100.00 Very High Very High Very High
Lasting pain 10 100.00 Very High Very High Very High
intrathecal 3 99.98 Very High Very High Very High
Pain 141 99.96 Very High Very High Very High
Biofeedback 5 99.96 Very High Very High Very High
Paracetamol 5 99.08 Very High Very High Very High
alcohol 42 98.72 Very High Very High Very High
Locus ceruleus 5 98.56 Very High Very High Very High
cINOD 1 97.84 Very High Very High Very High
Mcgill questionnaire 5 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 529 100.00 Very High Very High Very High
Pain 134 100.00 Very High Very High Very High
Cerebral Palsy 106 100.00 Very High Very High Very High
Premature Aging 2 100.00 Very High Very High Very High
Spasticity 40 99.98 Very High Very High Very High
Aging 7 99.98 Very High Very High Very High
Cystadenoma 63 99.92 Very High Very High Very High
Infection 105 99.68 Very High Very High Very High
Pancreatic Cancer 197 99.64 Very High Very High Very High
Hepatitis 4 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and ceruloplasmin levels were measured in serum samples of rats using the commercial kit, Abbott Architect C–8000 Autoanalyzer (Abbott Laboratories, USA).
Gene_expression (levels) of ceruloplasmin
1) Confidence 0.65 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020349 Disease Relevance 0.23 Pain Relevance 0.18
Plasma copper and ceruloplasmin decreased, whereas total cholesterol and LDL cholesterol increased [70].
Gene_expression (decreased) of ceruloplasmin in Plasma associated with disorder of lipid metabolism
2) Confidence 0.65 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872358 Disease Relevance 0.76 Pain Relevance 0
The C-propeptide of type II collagen (CPII) is cleaved from the procollagen molecule as it forms fibrils.
Gene_expression (propeptide) of CPII
3) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212578 Disease Relevance 0.10 Pain Relevance 0.04
[Oxidase activity of ceruloplasmin and the state of hemocoagulation in patients with chronic pancreatitis].
Gene_expression (activity) of ceruloplasmin associated with chronic pancreatitis
4) Confidence 0.65 Published 2003 Journal Eksp Klin Gastroenterol Section Title Doc Link 14653239 Disease Relevance 0.27 Pain Relevance 0.19
The apo A-IV concentration was positively correlated with hemoglobin A(1c) (HbA(1c)) percentage in each group of diabetic patients (CP-DM, r =.35; P =.046; type 1 DM, r =.53; P =.010), in both groups of diabetic patients (r =.472; P <.0001) and negatively correlated with ceruloplasmin concentration in each group of diabetic patients (CP-DM, r = -.48; P =.0052; type 1 DM, r = -.66; P =.003), in both groups of diabetic patients (r = -.561; P <.0001), and in the whole population (r = -.463; P <.0001).
Gene_expression (concentration) of ceruloplasmin associated with diabetes mellitus
5) Confidence 0.65 Published 2001 Journal Metab. Clin. Exp. Section Abstract Doc Link 11555832 Disease Relevance 2.64 Pain Relevance 0.57
Serologies for hepatitis A, B, and C were negative, as were antinuclear antibodies and ceruloplasmin.
Neg (negative) Gene_expression (negative) of ceruloplasmin associated with hepatitis
6) Confidence 0.65 Published 1999 Journal Am. J. Gastroenterol. Section Abstract Doc Link 10235225 Disease Relevance 0.98 Pain Relevance 0.10
Results observed for the CP fluctuations along the M-L direction suggest that pain stimulation clearly modified the upright standing behaviors.
Gene_expression (fluctuations) of CP associated with pain
7) Confidence 0.58 Published 2003 Journal BMC Musculoskelet Disord Section Body Doc Link PMC270027 Disease Relevance 0.72 Pain Relevance 0.72
Levels of haemoglobin, vitamin C, retinol, ceruloplasmin, riboflavin (EGRAC), folic acid, vitamin B12 and erythrocyte membrane zinc (RBCMZn) in blood were estimated.


Gene_expression (Levels) of ceruloplasmin in blood
8) Confidence 0.58 Published 2007 Journal Scandinavian Journal of Food & Nutrition Section Abstract Doc Link PMC2606995 Disease Relevance 0.07 Pain Relevance 0
In transition to remission, the levels of cytokines and acute phase proteins (lactoferrin, ceruloplasmin) went down.
Gene_expression (levels) of ceruloplasmin
9) Confidence 0.58 Published 2004 Journal Ter. Arkh. Section Body Doc Link 15106406 Disease Relevance 0.24 Pain Relevance 0
The levels of ceruloplasmin in the serum of blood taken from the veins of the back side of the foot were determined in 66 patients with the radicular syndrome of lumbar osteochondritis and in 7 normal subjects (control).
Spec (determined) Gene_expression (levels) of ceruloplasmin in foot associated with syndrome and osgood schlatter disease
10) Confidence 0.58 Published 1985 Journal Zh Nevropatol Psikhiatr Im S S Korsakova Section Abstract Doc Link 4002941 Disease Relevance 0.41 Pain Relevance 0.21
When CP (10 mM) was introduced alone into the medium, the level of malondialdehyde and the reactive oxygen species were maintained at the control levels with a simultaneous increase of non-protein sulfhydryl in the cells.
Gene_expression (introduced) of CP
11) Confidence 0.53 Published 1997 Journal Acta Biochim. Pol. Section Abstract Doc Link 9584856 Disease Relevance 0.17 Pain Relevance 0.34
Cold Pressor (CP) pain was induced in 97 healthy participants who precalled CP pain and then reported their actual experiences of CP pain, using the McGill Pain Questionnaire (MPQ) and a Visual Analogue Scale (VAS).
Gene_expression (precalled) of CP associated with pain and mcgill questionnaire
12) Confidence 0.47 Published 2007 Journal J Pain Section Abstract Doc Link 17306627 Disease Relevance 1.01 Pain Relevance 1.24
There are several possible explanations for the statistically significant difference between the SOmaxP group and CP, and these may be explained in part by several of the proprietary ingredients.
Gene_expression (group) of CP
13) Confidence 0.35 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC3016253 Disease Relevance 0.26 Pain Relevance 0
Mesotrypsin (PRSS3) can degrade intrapancreatic trypsin inhibitors that protect against CP.
Gene_expression (protect) of CP associated with chronic pancreatitis
14) Confidence 0.34 Published 2010 Journal Pancreatology Section Abstract Doc Link 20484962 Disease Relevance 0.37 Pain Relevance 0.46
This carbohydrate is present in honey and has been associated with delayed digestion and absorption, which may account for the difference in body fat changes between the SOmaxP group and the CP group.
Gene_expression (group) of CP in body
15) Confidence 0.30 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC3016253 Disease Relevance 0.17 Pain Relevance 0.09
Statistically significant differences between the SOmaxP and CP cohorts were observed for 1 RM (p = 0.019), RTF (p = 0.004), body fat percent (p = 0.028), lean mass (p = 0.049), and fat mass (p = 0.023).
Gene_expression (cohorts) of CP in body
16) Confidence 0.30 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC3016253 Disease Relevance 0 Pain Relevance 0
In CP, IHH and its receptors were present in the cells forming tubular complexes and in the islets with a different signal pattern compared with the islets in the normal pancreas.
Gene_expression (present) of CP in pancreas associated with chronic pancreatitis
17) Confidence 0.28 Published 2003 Journal J. Endocrinol. Section Abstract Doc Link 12967338 Disease Relevance 0.83 Pain Relevance 0.66
-1-antichymotrypsin; the metal transport and antioxidant proteins ceruloplasmin (ferroxidase II), haptoglobin and orosomucoid 2 (ORM2; ?
Gene_expression (proteins) of ceruloplasmin
18) Confidence 0.27 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 0.64 Pain Relevance 0.08
Intentional sheltering was shown to attenuate the expression of the CP-related Fos-Li activity within the locus coeruleus (LC) without affecting that of the structures known preferentially to process nociceptive inputs of bladder origin (dorsal vagal complex, ventrocaudal bulbar reticular formation, nucleus centralis of amygdala, dorsolateral portion of bed nucleus of stria terminalis).
Gene_expression (expression) of CP in dorsal associated with nociception, locus ceruleus and amygdala
19) Confidence 0.25 Published 2000 Journal Brain Res Cogn Brain Res Section Abstract Doc Link 10978698 Disease Relevance 0.65 Pain Relevance 0.38
Initially an autosomal recessive inheritance pattern was suspected for the N34S SPINK1 mutation resulting in CP in homozygous patients while another heterozygous subgroup seems to suffer from disease due to a combination of genetic defects of SPINK1 and yet unidentified genes [12].
Gene_expression (resulting) of CP associated with disease and chronic pancreatitis
20) Confidence 0.23 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.26 Pain Relevance 0.72

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