INT3962

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Context Info
Confidence 0.62
First Reported 1976
Last Reported 2010
Negated 6
Speculated 8
Reported most in Abstract
Documents 50
Total Number 57
Disease Relevance 20.96
Pain Relevance 13.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGT) small molecule metabolic process (AGT) aging (AGT)
extracellular region (AGT) extracellular matrix organization (AGT) cell-cell signaling (AGT)
Anatomy Link Frequency
blood 10
plasma 5
cardiac muscle 2
vein 2
Umbilical artery 1
AGT (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 33 100.00 Very High Very High Very High
noradrenaline 32 100.00 Very High Very High Very High
Clonidine 17 100.00 Very High Very High Very High
anesthesia 15 100.00 Very High Very High Very High
Morphine 8 100.00 Very High Very High Very High
agonist 8 100.00 Very High Very High Very High
adenocard 6 100.00 Very High Very High Very High
Catecholamine 6 100.00 Very High Very High Very High
substance P 4 100.00 Very High Very High Very High
Nicotine 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 54 100.00 Very High Very High Very High
Natriuresis 23 100.00 Very High Very High Very High
INFLAMMATION 104 99.16 Very High Very High Very High
Hypertension 154 98.96 Very High Very High Very High
Pressure And Volume Under Development 54 98.92 Very High Very High Very High
Hypotension 11 98.80 Very High Very High Very High
Pressure Volume 2 Under Development 25 98.68 Very High Very High Very High
Headache 19 98.64 Very High Very High Very High
Myocardial Infarction 137 98.28 Very High Very High Very High
Injury 17 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies have shown that opiate blockade can attenuate the development of hypertension and reduce blood pressure in chronic hypertension possibly via actions on the baroreflexes and/or by modulating the centrally mediated pressor actions of angiotensin II.
Regulation (modulating) of angiotensin II in blood associated with hypertension and opiate
1) Confidence 0.62 Published 1989 Journal Clin Exp Hypertens A Section Abstract Doc Link 2653668 Disease Relevance 0.99 Pain Relevance 0.83
Local renin-angiotensin regulation is present in the eye (Danser et al 1994; Wagner et al 1996).
Regulation (regulation) of angiotensin in eye
2) Confidence 0.60 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701139 Disease Relevance 0.49 Pain Relevance 0.03
This study in 13 healthy volunteers was performed to establish the influence of locally infused clonidine, angiotensin II, norepinephrine, and prostaglandin F2 alpha (PGF2 alpha) on hand vein diameter in a nonsystemically active dose range.
Regulation (influence) of angiotensin II in vein associated with clonidine
3) Confidence 0.58 Published 1992 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1378138 Disease Relevance 0.08 Pain Relevance 0.19
The same stimulus also triggers an increase in the levels of circulating vasoactive hormones, such as norepinephrine and angiotensin II, further augmenting arteriolar tone.
Regulation (circulating) of angiotensin II
4) Confidence 0.44 Published 1993 Journal Physiologist Section Abstract Doc Link 11537414 Disease Relevance 0.56 Pain Relevance 0.06
Finally, there was no significant change in the markers of the renin-angiotensin system in the circulating blood although an increase in aldosterone was observed after rapid pacing only in the control group.
Neg (no) Regulation (change) of angiotensin in blood
5) Confidence 0.44 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2267894 Disease Relevance 0.08 Pain Relevance 0
Clinical trials indicated that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are effective in the prophylactic treatment of migraine.
Regulation (effective) of angiotensin associated with migraine
6) Confidence 0.44 Published 2006 Journal J Hypertens Suppl Section Abstract Doc Link 16601567 Disease Relevance 0.79 Pain Relevance 0.79
Effect of centrally acting antihypertensive drugs on the renin-angiotensin system and vasopressin.
Regulation (Effect) of angiotensin
7) Confidence 0.44 Published 1984 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 6084128 Disease Relevance 0 Pain Relevance 0.10
In a randomized double blind placebo-controlled cross-over study we therefore examined the effect of 14-day GH administration (12 IU sc at 2000 h) on plasma volume, extracellular volume (ECV), atrial natriuretic peptide (ANP), arginine vasopressin, and the renin angiotensin system in eight healthy adult men.
Spec (examined) Regulation (effect) of angiotensin in plasma associated with natriuresis
8) Confidence 0.44 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1826008 Disease Relevance 0.27 Pain Relevance 0
To assess the dependency of blood pressure on the direct effects of angiotensin II, the same patients were studied on a separate occasion after administration of the angiotensin converting enzyme (ACE) inhibitor, captopril.
Regulation (effects) of angiotensin II in blood
9) Confidence 0.37 Published 1988 Journal J Hypertens Suppl Section Abstract Doc Link 3071592 Disease Relevance 0.49 Pain Relevance 0.36
In these patients captopril had minimal hypotensive effects, indicating a smaller role for the direct vascular effects of angiotensin II.
Regulation (effects) of angiotensin II associated with hypotension
10) Confidence 0.37 Published 1988 Journal J Hypertens Suppl Section Abstract Doc Link 3071592 Disease Relevance 0.71 Pain Relevance 0.37
Beta 2-adrenergic receptor and angiotensin II receptor modulation of sympathetic neurotransmission in human atria.
Regulation (modulation) of angiotensin II in sympathetic
11) Confidence 0.36 Published 1994 Journal Circ. Res. Section Title Doc Link 8118951 Disease Relevance 0 Pain Relevance 0.10
The aim of the present study was to investigate beta-adrenergic receptor and angiotensin II (Ang II) receptor modulation of norepinephrine release in human atria.
Spec (investigate) Regulation (modulation) of angiotensin II
12) Confidence 0.36 Published 1994 Journal Circ. Res. Section Abstract Doc Link 8118951 Disease Relevance 0 Pain Relevance 0.06
Thus, in the non-failing heart, without chronic adrenergic activation, no angiotensin II-facilitated effect on cardiac noradrenaline spillover could be detected.
Regulation (effect) of angiotensin II in heart associated with noradrenaline
13) Confidence 0.34 Published 1997 Journal Acta Physiol. Scand. Section Abstract Doc Link 9381945 Disease Relevance 0.05 Pain Relevance 0.23
Mean arterial pressure, peripheral plasma renin activity and angiotensin II levels were also unaffected by enalaprilat infusion.
Neg (unaffected) Regulation (unaffected) of angiotensin II in plasma
14) Confidence 0.34 Published 1997 Journal Acta Physiol. Scand. Section Abstract Doc Link 9381945 Disease Relevance 0.13 Pain Relevance 0.30
The effect of systemic angiotensin II (ANG II) administration on the posterior pituitary function was investigated in normal men.
Regulation (effect) of angiotensin II in posterior pituitary
15) Confidence 0.33 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 2041583 Disease Relevance 0 Pain Relevance 0.34
The increase of epinephrine and norepinephrine levels were suppressed during the surgery and there were no significant changes in plasma renin activity, angiotensin II and aldosterone levels.
Neg (no) Regulation (changes) of angiotensin II in plasma
16) Confidence 0.32 Published 1997 Journal Masui Section Abstract Doc Link 9132512 Disease Relevance 0.24 Pain Relevance 0.31
Mechanism for the postive inotropic effect of angiotensin II on isolated cardiac muscle.
Regulation (effect) of angiotensin II in cardiac muscle
17) Confidence 0.32 Published 1976 Journal Circ. Res. Section Title Doc Link 939002 Disease Relevance 0 Pain Relevance 0.42
The roles of angiotensin II and prostaglandins in the regulation of the glomerular filtration of albumin.
Regulation (roles) of angiotensin II
18) Confidence 0.31 Published 1990 Journal J Hypertens Suppl Section Title Doc Link 2185353 Disease Relevance 0.66 Pain Relevance 0.08
However, a reduction in glomerular prostacyclin production can possibly account for the prostaglandin dependence of renal function in these patients by virtue of the enhanced constrictor effects of angiotensin II on glomerular arterioles and mesangium.
Regulation (effects) of angiotensin II in mesangium associated with addiction
19) Confidence 0.29 Published 1986 Journal Am. J. Med. Section Abstract Doc Link 3092667 Disease Relevance 0.44 Pain Relevance 0.26
Naloxone had no effect on the pressor responses to intravenous angiotensin II or carotid artery occlusion.
Neg (no) Regulation (effect) of angiotensin II in carotid artery associated with narcan
20) Confidence 0.27 Published 1986 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 3720019 Disease Relevance 0.08 Pain Relevance 0.66

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