INT39634

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Context Info
Confidence 0.22
First Reported 1981
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.72
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (F2) peptidase activity (F2) extracellular space (F2)
extracellular region (F2) response to stress (F2)
Anatomy Link Frequency
plasma 2
liver 2
skin 2
F2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 12 99.80 Very High Very High Very High
epidural 4 88.16 High High
analgesia 4 87.80 High High
anesthesia 1 86.24 High High
Analgesic 1 84.12 Quite High
visual analogue scale 1 80.40 Quite High
withdrawal 21 73.36 Quite High
headache 9 71.04 Quite High
depression 2 52.64 Quite High
Migraine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemorrhage 37 100.00 Very High Very High Very High
Pain 10 99.80 Very High Very High Very High
Herpes Zoster 6 99.16 Very High Very High Very High
Hemorrhagic Diathesis 1 95.04 Very High Very High Very High
Diabetes Mellitus 2 79.68 Quite High
Substance Withdrawal Syndrome 1 73.36 Quite High
Headache 12 71.04 Quite High
Reprotox - General 1 17 62.60 Quite High
Depression 2 52.64 Quite High
Endometriosis (extended) 5 37.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The combined effects of orchiectomy and estrogen administration on synthesis of selected hepatic secretory proteins--antithrombin (AT) III, plasminogen, fibrinogen, factor II (prothrombin), factor VII, fibronectin, and albumin--were studied using the isolated rat liver perfused in vitro for ten hours.
Regulation (effects) of Gene_expression (synthesis) of prothrombin in liver
1) Confidence 0.22 Published 1985 Journal Blood Section Abstract Doc Link 4016277 Disease Relevance 0 Pain Relevance 0.09
Postoperative changes in various haemostatic parameters (capillary bleeding time, platelet count, fibrinogen, fibrinmonomers, prothrombin, antithrombin III, factor VIII procoagulant, factor VIII antigen, euglobulin clot lysis time, streptokinase lysis time, fibrinogen related antigens, alpha 1-antitrypsin and alpha 2-macroglobulin) plasma glucose and cortisol were studied in 12 female patients undergoing elective abdominal hysterectomy during either general anaesthesia or epidural analgesia (T4-S5).
Regulation (changes) of Gene_expression (procoagulant) of prothrombin in plasma associated with epidural, hemorrhage and analgesia
2) Confidence 0.05 Published 1981 Journal Br J Surg Section Abstract Doc Link 7225737 Disease Relevance 0.15 Pain Relevance 0.39
Up-regulation of prothrombin expression by the vascular endothelial and sweat gland epithelial cells in the active skin lesion and transient elevation of plasma thrombin-antithrombin III complex levels in a proportion of patients suggest a lesional generation of thrombin in herpes zoster.
Regulation (regulation) of Gene_expression (expression) of prothrombin in skin associated with herpes zoster
3) Confidence 0.02 Published 2001 Journal J. Dermatol. Section Abstract Doc Link 11449671 Disease Relevance 0.89 Pain Relevance 0.60
In users of the DNG-containing oral contraceptives, the reduction in total and free protein S, and in t-PA and PAI was dependent on the EE dose, while factor VII activity was elevated, but not significantly different from that with EE/LNG.13 The levels of high-density lipoprotein cholesterol increased, while the levels of prothrombin fragment 1 + 2 and D-dimer remained relatively unchanged; in contrast, the levels of SHBG, CBG and TBG increased.38
Neg (unchanged) Regulation (unchanged) of Gene_expression (levels) of prothrombin
4) Confidence 0.01 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2990895 Disease Relevance 0.68 Pain Relevance 0.23

General Comments

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