INT39677

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Context Info
Confidence 0.17
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 2.17
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Atrn) extracellular space (Atrn) extracellular region (Atrn)
plasma membrane (Atrn) molecular_function (Atrn) cytoplasm (Atrn)
Anatomy Link Frequency
plasma 1
liver 1
BBM 1
kidney 1
Atrn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 4 100.00 Very High Very High Very High
Morphine 5 99.84 Very High Very High Very High
aspirin 18 99.50 Very High Very High Very High
Paracetamol 3 96.80 Very High Very High Very High
dorsal root ganglion 3 91.16 High High
imagery 1 90.88 High High
addiction 1 88.56 High High
Opioid 1 86.64 High High
Pain 4 84.40 Quite High
Inflammatory mediators 2 83.04 Quite High
Disease Link Frequency Relevance Heat
Body Weight 12 99.72 Very High Very High Very High
Lead Poisoning 2 97.24 Very High Very High Very High
Necrosis 1 95.04 Very High Very High Very High
Ganglion Cysts 3 91.16 High High
Morphine Dependence 1 88.56 High High
Pain 4 84.40 Quite High
Nociception 7 83.36 Quite High
Hepatotoxicity 3 80.72 Quite High
INFLAMMATION 7 75.00 Quite High
Disease 4 69.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Depletion of protective intracellular GSH by diethyl maleate treatment (400 mg/kg) alone minimally decreased control plasma membrane uptake activity, although the GSH depletion markedly potentiated the effect of acetaminophen on the plasma membrane and on necrosis.
Negative_regulation (decreased) of membrane in plasma associated with necrosis and paracetamol
1) Confidence 0.17 Published 1985 Journal Mol. Pharmacol. Section Abstract Doc Link 4021997 Disease Relevance 0.24 Pain Relevance 0.28
The results show that the membrane fluidity of red cells was greatly reduced by morphine and the secondary structure of membrane proteins was changed.
Negative_regulation (reduced) of membrane associated with morphine
2) Confidence 0.17 Published 2000 Journal Clin. Hemorheol. Microcirc. Section Abstract Doc Link 10976712 Disease Relevance 0.09 Pain Relevance 0.57
Aspirin treatment also led to a decrease in the microviscosity in the native as well as the benzyl alcohol treated membrane which might be due to the lipid peroxidative damage in the membrane.
Negative_regulation (decrease) of membrane associated with aspirin and alcohol
3) Confidence 0.02 Published 2010 Journal Nutr Hosp Section Abstract Doc Link 20449540 Disease Relevance 0.09 Pain Relevance 0.25
Aspirin at a dose of 50 mg/kg body weight was found to decrease the activity of the rat intestinal brush border membrane (BBM) - associated enzymes such as the sucrase, lactase, maltase and alkaline phosphatase.
Negative_regulation (decrease) of membrane in BBM associated with aspirin and body weight
4) Confidence 0.02 Published 2010 Journal Nutr Hosp Section Abstract Doc Link 20449540 Disease Relevance 0.10 Pain Relevance 0.21
Further experiments demonstrated that M current inhibition required concurrent rises in cytosolic Ca(2+) concentration and depletion of membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)).
Negative_regulation (depletion) of membrane
5) Confidence 0.01 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18971466 Disease Relevance 0.92 Pain Relevance 0.48
Inorganic lead is a prooxidant and peroxidative damage to cellular membrane lipids and fatty acids leads to membrane fragility and permeability is a likely consequence of lead poisoning.36 The increased concentration of cholesterol could result in a relative molecular ordering of the residual phospholipids resulting in a decrease in membrane fluidity.37 The increased concentration of free fatty acids in liver and kidney may be due to lipid breakdown and this may cause increased generation of nicotinamide adenine dinucleotide phosphate (NADPH), which results in the activation of NADPH dependent microsomal lipid peroxidation.
Negative_regulation (decrease) of membrane in liver associated with lead poisoning
6) Confidence 0.01 Published 2008 Journal Indian Journal of Nephrology Section Body Doc Link PMC2813123 Disease Relevance 0.36 Pain Relevance 0
Inorganic lead is a prooxidant and peroxidative damage to cellular membrane lipids and fatty acids leads to membrane fragility and permeability is a likely consequence of lead poisoning.36 The increased concentration of cholesterol could result in a relative molecular ordering of the residual phospholipids resulting in a decrease in membrane fluidity.37 The increased concentration of free fatty acids in liver and kidney may be due to lipid breakdown and this may cause increased generation of nicotinamide adenine dinucleotide phosphate (NADPH), which results in the activation of NADPH dependent microsomal lipid peroxidation.
Negative_regulation (decrease) of membrane in kidney associated with lead poisoning
7) Confidence 0.00 Published 2008 Journal Indian Journal of Nephrology Section Body Doc Link PMC2813123 Disease Relevance 0.36 Pain Relevance 0

General Comments

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