INT39679

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Context Info
Confidence 0.11
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.29
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Atrn) extracellular space (Atrn) extracellular region (Atrn)
plasma membrane (Atrn) molecular_function (Atrn) cytoplasm (Atrn)
Anatomy Link Frequency
plasma 2
neuronal 1
neurons 1
intestine 1
Atrn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 7 100.00 Very High Very High Very High
Paracetamol 6 100.00 Very High Very High Very High
cINOD 1 100.00 Very High Very High Very High
Morphine 5 99.98 Very High Very High Very High
Neuronal excitability 1 99.62 Very High Very High Very High
Opioid 1 98.76 Very High Very High Very High
Neurotransmitter 3 98.72 Very High Very High Very High
Pain 12 88.88 High High
Peripheral nerve injury 1 88.00 High High
nMDA receptor 7 84.68 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 3 100.00 Very High Very High Very High
Necrosis 2 99.68 Very High Very High Very High
Hepatotoxicity 2 99.46 Very High Very High Very High
Injury 8 94.96 High High
Drug Induced Neurotoxicity 1 91.52 High High
Pain 4 88.88 High High
Nervous System Injury 10 87.12 High High
Occupational Diseases 1 86.32 High High
Poisoning 1 84.96 Quite High
Morphine Dependence 1 82.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Depletion of protective intracellular GSH by diethyl maleate treatment (400 mg/kg) alone minimally decreased control plasma membrane uptake activity, although the GSH depletion markedly potentiated the effect of acetaminophen on the plasma membrane and on necrosis.
Regulation (effect) of membrane in plasma associated with necrosis and paracetamol
1) Confidence 0.11 Published 1985 Journal Mol. Pharmacol. Section Abstract Doc Link 4021997 Disease Relevance 0.25 Pain Relevance 0.27
Alkylation of sites on the plasma membrane may be a key chemical-macromolecule interaction in drug-induced liver necrosis, and inhibition of plasma membrane Ca2+ regulation may provide a connecting link between the alkylation hypothesis and the perturbed Ca2+ homeostasis hypothesis of lethal cell injury.
Regulation (regulation) of membrane in plasma associated with injury and hepatotoxicity
2) Confidence 0.11 Published 1985 Journal Mol. Pharmacol. Section Abstract Doc Link 4021997 Disease Relevance 0.34 Pain Relevance 0.25
This suggests that morphine affects the rat red cell membrane directly, rather than through opioids-receptors.
Regulation (affects) of membrane associated with opioid and morphine
3) Confidence 0.11 Published 2000 Journal Clin. Hemorheol. Microcirc. Section Abstract Doc Link 10976712 Disease Relevance 0.08 Pain Relevance 0.57
The toxic mechanisms of lead on the molecular machinery of living organisms include metal transport, energy metabolism, diverse enzymatic processes, genetic regulation, and membrane ionic channels and signaling molecules.
Regulation (regulation) of membrane
4) Confidence 0.00 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 19925858 Disease Relevance 0.26 Pain Relevance 0
Effects of non steroidal anti-inflammatory drugs on the antioxidant defense system and the membrane functions in the rat intestine.
Regulation (Effects) of membrane in intestine associated with aspirin, inflammation and cinod
5) Confidence 0.00 Published 2006 Journal Nutr Hosp Section Title Doc Link 17147060 Disease Relevance 0.10 Pain Relevance 0.29
ATP-sensitive potassium (KATP) channels in neurons mediate neuroprotection, they regulate membrane excitability, and they control neurotransmitter release.
Regulation (regulate) of membrane in neurons associated with neurotransmitter
6) Confidence 0.00 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2825500 Disease Relevance 0.18 Pain Relevance 0.33
Another possible mechanism by which ERK might modulate neuronal excitability is through direct regulation of membrane ion channels that regulate the membrane potential and thereby intrinsic membrane properties.
Regulation (regulation) of membrane in neuronal associated with neuronal excitability
7) Confidence 0.00 Published 2007 Journal Mol Pain Section Body Doc Link PMC1941723 Disease Relevance 0.08 Pain Relevance 0.50
Measurements of total Rh123 fluorescence from an intact cell can therefore be used to follow changes in mitochondrial membrane potential (?
Regulation (changes) of membrane
8) Confidence 0.00 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0 Pain Relevance 0

General Comments

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