INT39691

Context Info Confidence 0.59 First Reported 1985 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 5 Disease Relevance 1.46 Pain Relevance 3.88

cytosol (NR1I3) nucleoplasm (NR1I3) signal transduction (NR1I3) cytoskeleton (NR1I3) nucleus (NR1I3) DNA binding (NR1I3)

Anatomy Link Frequency CAR 4 NR1I3 (Homo sapiens)

Pain Link Frequency Relevance Heat Paracetamol 36 98.66 Analgesic 12 97.04 anesthesia 1 61.92

Disease Link Frequency Relevance Heat Death 4 99.74 Apoptosis 4 99.52 Toxicity 4 88.36 Hepatotoxicity 4 77.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In human hepatocytes (HEPG-2) and in human primary cultures of normal liver cells, APAP, but not 5a, was associated with apoptotic cell death, Fas-ligand up-regulation, and CAR (constitutive androstane receptor) activation, contributing to a favorable safety profile of 5a as an orally delivered analgesic.

Positive_regulation (up-regulation) of CAR in CAR associated with paracetamol, analgesic, apoptosis and death

1) Confidence 0.59 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 16919959 Disease Relevance 0.37 Pain Relevance 0.96

In human hepatocytes (HEPG-2) and in human primary cultures of normal liver cells, APAP, but not 5a, was associated with apoptotic cell death, Fas-ligand up-regulation, and CAR (constitutive androstane receptor) activation, contributing to a favorable safety profile of 5a as an orally delivered analgesic.

Positive_regulation (up-regulation) of androstane receptor in CAR associated with paracetamol, analgesic, apoptosis and death

2) Confidence 0.52 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 16919959 Disease Relevance 0.37 Pain Relevance 0.96

In human hepatocytes (HEPG-2) and in human primary cultures of normal liver cells, APAP, but not 5a, was associated with apoptotic cell death, Fas-ligand up-regulation, and CAR (constitutive androstane receptor) activation, contributing to a favorable safety profile of 5a as an orally delivered analgesic.

Positive_regulation (activation) of CAR in CAR associated with paracetamol, analgesic, apoptosis and death

3) Confidence 0.40 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 16919959 Disease Relevance 0.36 Pain Relevance 0.95

In human hepatocytes (HEPG-2) and in human primary cultures of normal liver cells, APAP, but not 5a, was associated with apoptotic cell death, Fas-ligand up-regulation, and CAR (constitutive androstane receptor) activation, contributing to a favorable safety profile of 5a as an orally delivered analgesic.

Positive_regulation (activation) of androstane receptor in CAR associated with paracetamol, analgesic, apoptosis and death

4) Confidence 0.35 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 16919959 Disease Relevance 0.36 Pain Relevance 0.95

For the BAER, progressive and significant increases in the latencies of Waves I, III, V (e.g., Wave V latency: 6.16 +/- 0.24 vs. 6.87 +/- 0.31 ms) and in the I-III, III-V, and the I-V interwave latencies were observed.

Positive_regulation (increases) of I-III

5) Confidence 0.02 Published 1985 Journal Anesthesiology Section Abstract Doc Link 4025886 Disease Relevance 0 Pain Relevance 0.06

General Comments

This test has worked.