INT39699

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Context Info
Confidence 0.41
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 3.73
Pain Relevance 10.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RYBP) nucleus (RYBP) intracellular (RYBP)
DNA binding (RYBP) cytoplasm (RYBP)
Anatomy Link Frequency
liver 4
plasma 2
blood 2
RYBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 144 100.00 Very High Very High Very High
Leflunomide 8 97.84 Very High Very High Very High
Analgesic 3 96.92 Very High Very High Very High
anesthesia 1 96.36 Very High Very High Very High
Bile 2 85.68 High High
Disease Link Frequency Relevance Heat
Hepatotoxicity 24 99.96 Very High Very High Very High
Toxicity 12 99.56 Very High Very High Very High
Methemoglobinemia 1 99.10 Very High Very High Very High
Necrosis 3 97.68 Very High Very High Very High
Injury 11 92.44 High High
Stress 3 81.76 Quite High
Nephrotoxicity 3 75.00 Quite High
Body Weight 1 71.96 Quite High
Overdose 1 64.12 Quite High
Hypoxia 2 60.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To selectively inhibit APAP activation in the kidney but not in the liver, 10-week-old male CD-1 mice were castrated under ether anesthesia and allowed to recover for a minimum of 2 weeks before use.
Negative_regulation (inhibit) of Positive_regulation (activation) of APAP in liver associated with anesthesia and paracetamol
1) Confidence 0.41 Published 1994 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 8209379 Disease Relevance 0.30 Pain Relevance 0.86
At the dosage levels used, oral NAC, IV NAC, and IV sodium sulfate were equally effective antidotes, as measured by decreased methemoglobinemia, increased whole blood reduced glutathione, decreased APAP half-lives, and increased urinary excretion of the APAP-sulfate conjugate.
Negative_regulation (decreased) of Positive_regulation (increased) of APAP-sulfate conjugate in blood associated with paracetamol and methemoglobinemia
2) Confidence 0.36 Published 1985 Journal Am. J. Vet. Res. Section Abstract Doc Link 4026031 Disease Relevance 0.17 Pain Relevance 0.90
When APAP and LEF were incubated with human recombinant P450 enzymes, CYP1A2 was found to be the isozyme responsible for the inhibition of APAP bioactivation.
Negative_regulation (inhibition) of Positive_regulation (bioactivation) of APAP associated with paracetamol and leflunomide
3) Confidence 0.31 Published 2008 Journal Toxicol. Lett. Section Abstract Doc Link 18588957 Disease Relevance 0.40 Pain Relevance 1.26
A dose of DMSO (1 ml/kg, i.p.) inhibited the induction of APAP hepatotoxicity almost completely as indicated by changes in serum hepatotoxic parameters.
Negative_regulation (inhibited) of Positive_regulation (induction) of APAP associated with paracetamol and hepatotoxicity
4) Confidence 0.28 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16880615 Disease Relevance 0.27 Pain Relevance 0.84
Preferential secretion of APAP-glu into blood decreased enterohepatic recirculation of APAP, thus attenuating liver exposition to the intact drug, as demonstrated 6h after administration with the toxic dose.
Negative_regulation (decreased) of Positive_regulation (recirculation) of APAP in liver associated with paracetamol
5) Confidence 0.21 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19426699 Disease Relevance 0.23 Pain Relevance 1.36
Thus, the greater hepatotoxicity of APAP administered at 20:00 h appears to be related to the marked decrease in hepatic GSH at this time period, whereas the simultaneous reduction in APAP activation may be responsible for the lack of hepatotoxicity in mice treated with this analgesic at 14:00 h.
Negative_regulation (reduction) of Positive_regulation (activation) of APAP associated with paracetamol, analgesic and hepatotoxicity
6) Confidence 0.18 Published 1998 Journal Toxicology Section Abstract Doc Link 9704905 Disease Relevance 0.36 Pain Relevance 1.17
The protective action of PEITC against APAP toxicity is attributed to the blocking of APAP activation through inhibition of P450 enzymes.
Negative_regulation (blocking) of Positive_regulation (activation) of APAP associated with toxicity and paracetamol
7) Confidence 0.15 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9194414 Disease Relevance 0.50 Pain Relevance 1.20
Moreover, hepatic glutathione was decreased to a similar extent regardless of TA pretreatment, suggesting that decreased bioactivation of APAP is unlikely to be the mechanism underlying TA protection. [3H]Thymidine incorporation studies confirmed the expected stimulation of S-phase synthesis, and proliferating cell nuclear antigen studies showed a corresponding stimulation of cell division through accelerated cell cycle progression.
Negative_regulation (decreased) of Positive_regulation (bioactivation) of APAP associated with paracetamol
8) Confidence 0.08 Published 1995 Journal Hepatology Section Abstract Doc Link 7843722 Disease Relevance 0.31 Pain Relevance 0.93
Loss of hepatocellular glutathione was similar in APAP-treated mice pretreated with saline or heparin, suggesting that heparin did not diminish bioactivation of APAP.
Neg (not) Negative_regulation (diminish) of Positive_regulation (bioactivation) of APAP
9) Confidence 0.02 Published 2007 Journal Hepatology Section Abstract Doc Link 17654741 Disease Relevance 0.65 Pain Relevance 0.13
APAP pretreatment reduced the elevation of APAP-sulfate, but increased APAP-cysteine concentrations in plasma.
Negative_regulation (reduced) of Positive_regulation (elevation) of APAP in plasma associated with paracetamol
10) Confidence 0.01 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19834287 Disease Relevance 0.16 Pain Relevance 1.22
Pretreatment with AA (50 and 100mg/kg) orally 2h before the APAP administration attenuated the APAP-induced acute increase in serum aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activites, replenished the depleted hepatic glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activities, decreased malondialdehyde (MDA) level and considerably reduced the histopathological alterations in a manner similar to silymarin (Sily).
Negative_regulation (attenuated) of Positive_regulation (increase) of APAP associated with paracetamol
11) Confidence 0.01 Published 2010 Journal Phytomedicine Section Abstract Doc Link 19836221 Disease Relevance 0.38 Pain Relevance 0.55

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