INT3970

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Context Info
Confidence 0.70
First Reported 1976
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 4.29
Pain Relevance 3.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sord) oxidoreductase activity (Sord) cilium (Sord)
cellular_component (Sord)
Anatomy Link Frequency
liver 3
plasma 1
Sord (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 2 100.00 Very High Very High Very High
Paracetamol 30 99.56 Very High Very High Very High
anesthesia 5 99.10 Very High Very High Very High
halothane 6 98.52 Very High Very High Very High
abdominal pain 1 98.20 Very High Very High Very High
cryotherapy 76 90.32 High High
fibrosis 1 88.56 High High
Bile 1 87.76 High High
noradrenaline 2 67.52 Quite High
Analgesic 2 59.56 Quite High
Disease Link Frequency Relevance Heat
Hyperlipidemia 3 99.96 Very High Very High Very High
Hepatotoxicity 13 99.84 Very High Very High Very High
Acid Base Imbalance 2 99.56 Very High Very High Very High
Uremia 1 98.76 Very High Very High Very High
Abdominal Pain 1 98.20 Very High Very High Very High
Jaundice 1 97.16 Very High Very High Very High
Appetite Loss 2 96.76 Very High Very High Very High
Toxicity 2 96.12 Very High Very High Very High
Fever 3 96.04 Very High Very High Very High
Weight Loss 3 95.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using this model, it was shown that administration of metyrapone (2-methyl-1,2-bis(3-pyridyl)-1-propanone) (100 mg/kg b.w.) 1 h prior to anesthesia prevents liver necrosis and the concomitant increase in serum sorbitol dehydrogenase activity.
Positive_regulation (increase) of sorbitol dehydrogenase in liver associated with anesthesia and hepatotoxicity
1) Confidence 0.70 Published 1982 Journal Anaesthesist Section Abstract Doc Link 6807128 Disease Relevance 0.26 Pain Relevance 0.32
Liver necrosis and an increase of serum sorbitol dehydrogenase activity can be produced in rats by halothane anesthesia (1% v/v in oxygen) following pretreatment with polychlorinated biphenyls.
Positive_regulation (increase) of sorbitol dehydrogenase in Liver associated with anesthesia, hepatotoxicity and halothane
2) Confidence 0.47 Published 1982 Journal Anaesthesist Section Abstract Doc Link 6807128 Disease Relevance 0.25 Pain Relevance 0.30
Both doses of acetaminophen produced significant elevations of serum alanine aminotransferase (ALT) and sorbitol dehydrogenase (SDH) activities in 4-month-old rats.
Positive_regulation (elevations) of sorbitol dehydrogenase associated with paracetamol
3) Confidence 0.35 Published 1988 Journal Drug Chem Toxicol Section Abstract Doc Link 3181038 Disease Relevance 0.24 Pain Relevance 0.42
An intraperitoneal dose of APAP (500 mg/kg) alone did not increase aspartate aminotransferase, alanine aminotransferase, or sorbitol dehydrogenase activity in serum, but was significantly hepatotoxic when the rats had been pretreated with an identical dose of APAP 18 h earlier.
Neg (not) Positive_regulation (increase) of sorbitol dehydrogenase associated with paracetamol
4) Confidence 0.27 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19834287 Disease Relevance 0.17 Pain Relevance 1.06
Findings of hypertriglyceridemia, hypercholesterolemia, elevated sorbitol dehydrogenase activity, metabolic acidosis, azotemia, and ketonuria occurred in these two camelids.
Positive_regulation (elevated) of sorbitol dehydrogenase associated with hyperlipidemia, uremia and acid base imbalance
5) Confidence 0.25 Published 1994 Journal J. Vet. Intern. Med. Section Abstract Doc Link 8064656 Disease Relevance 1.09 Pain Relevance 0.08
On the other hand, dose-dependent elevations in serum enzyme glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT) and sorbitol dehydrogenase (SDH) activities and hepatic triglyceride (TG) levels were observed following the administration of single doses of 0.5 and lg/kg acetaminophen.
Positive_regulation (elevations) of sorbitol dehydrogenase associated with paracetamol
6) Confidence 0.25 Published 1976 Journal Toxicology Section Abstract Doc Link 941168 Disease Relevance 0.15 Pain Relevance 0.53
Either single or repeated DDB pretreatment (50 or 200 mg/kg) did not alter the hepatotoxicity induced by carbon tetrachloride (0.2 or 1.0 ml/kg, i.p.) in female rats as indicated by increases in the activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and sorbitol dehydrogenase (SDH) in serum.
Positive_regulation (increases) of sorbitol dehydrogenase associated with hepatotoxicity
7) Confidence 0.14 Published 1999 Journal Biol. Pharm. Bull. Section Abstract Doc Link 9989671 Disease Relevance 0.36 Pain Relevance 0.19
Statistically significant increases in the activities of glutamate dehydrogenase, sorbitol dehydrogenase, malate dehydrogenase, ornithine transcarbamoylase, and arginase were observed in the plasma and liver.
Positive_regulation (increases) of sorbitol dehydrogenase in plasma associated with glutamate
8) Confidence 0.08 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734249 Disease Relevance 0.44 Pain Relevance 0.43
Values for alkaline phosphatase, bilirubin, gamma-glutamyl transferase, sorbitol dehydrogenase, and bromsulpthalein half-life were increased and bilirubinuria was evident before surgery.
Positive_regulation (Values) of sorbitol dehydrogenase
9) Confidence 0.07 Published 1985 Journal J. Am. Vet. Med. Assoc. Section Abstract Doc Link 4019295 Disease Relevance 0.89 Pain Relevance 0.19
Statistically significant increases in the activities of glutamate dehydrogenase, sorbitol dehydrogenase, malate dehydrogenase, ornithine transcarbamoylase, and arginase were observed in the plasma and liver.
Positive_regulation (increases) of sorbitol dehydrogenase in liver associated with glutamate
10) Confidence 0.03 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734249 Disease Relevance 0.44 Pain Relevance 0.43

General Comments

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