INT39712

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Context Info
Confidence 0.48
First Reported 1985
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 82
Total Number 82
Disease Relevance 110.92
Pain Relevance 10.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 4
coronary artery 4
limb 3
leg 2
lower limbs 1
pad (Mus musculus)
Pain Link Frequency Relevance Heat
Restless leg syndrome 280 100.00 Very High Very High Very High
ischemia 85 100.00 Very High Very High Very High
Inflammation 91 99.98 Very High Very High Very High
peripheral neuropathy 20 99.92 Very High Very High Very High
Pain 119 98.04 Very High Very High Very High
aspirin 261 96.60 Very High Very High Very High
Inflammatory marker 25 93.76 High High
antagonist 5 89.44 High High
depression 12 80.36 Quite High
Arthritis 3 78.96 Quite High
Disease Link Frequency Relevance Heat
Peripheral Arterial Disease 2461 100.00 Very High Very High Very High
Atherosclerosis 457 100.00 Very High Very High Very High
Amputation 408 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 353 100.00 Very High Very High Very High
Skin Ulcer 267 100.00 Very High Very High Very High
Disease 249 100.00 Very High Very High Very High
Injury 80 100.00 Very High Very High Very High
Cv Unclassified Under Development 76 100.00 Very High Very High Very High
Hyperglycemia 25 100.00 Very High Very High Very High
INFLAMMATION 93 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PAD is a marker of systemic atherosclerosis and is associated with increased cardiovascular morbidity and mortality.
PAD Binding (associated) of associated with increased venous pressure under development and peripheral arterial disease
1) Confidence 0.48 Published 2009 Journal Curr Vasc Pharmacol Section Abstract Doc Link 19601864 Disease Relevance 1.05 Pain Relevance 0.27
In the general United States adult population, inflammation is independently associated with PAD in a cross-sectional, nationally large representative sample.
PAD Binding (associated) of associated with inflammation and peripheral arterial disease
2) Confidence 0.48 Published 2007 Journal Med. Hypotheses Section Abstract Doc Link 17555883 Disease Relevance 2.68 Pain Relevance 0.42
Importantly, PAD is a marker for generalized atherosclerosis and is closely associated with coronary and cerebrovascular disease.
PAD Binding (associated) of associated with cerebrovascular disease, increased venous pressure under development and peripheral arterial disease
3) Confidence 0.48 Published 2002 Journal Prev Cardiol Section Abstract Doc Link 12091754 Disease Relevance 1.39 Pain Relevance 0.14
The risk factors associated with PAD are similar to those found in patients with coronary artery disease and cerebrovascular disease.
PAD Binding (associated) of in coronary artery associated with cerebrovascular disease, coronary artery disease and peripheral arterial disease
4) Confidence 0.47 Published 2004 Journal J Vasc Interv Radiol Section Abstract Doc Link 15525738 Disease Relevance 0.80 Pain Relevance 0.06
Importantly, PAD is a marker of generalized atherosclerosis and is closely associated with coronary and cerebrovascular disease.
PAD Binding (associated) of associated with cerebrovascular disease, increased venous pressure under development and peripheral arterial disease
5) Confidence 0.47 Published 2003 Journal Curr Vasc Pharmacol Section Abstract Doc Link 15320844 Disease Relevance 1.50 Pain Relevance 0.14
One could argue that compared to the large publicity and public health initiatives on heart attacks and strokes, public recognition on the risks, morbidity and mortality associated with PAD has been relatively neglected.
PAD Binding (associated) of in heart associated with stroke, peripheral arterial disease and myocardial infarction
6) Confidence 0.41 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1166544 Disease Relevance 1.73 Pain Relevance 0.08
Risk factors associated with PAD include typical cardiovascular risk factors, such as older age, cigarette smoking, diabetes mellitus, hypercholesterolemia, and hypertension [1].
PAD Binding (associated) of associated with nicotine addiction, diabetes mellitus, hypertension, hyperlipidemia and peripheral arterial disease
7) Confidence 0.41 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1166544 Disease Relevance 1.34 Pain Relevance 0.08
PAD is a debilitating atherosclerotic disease of the lower limbs and is associated with an increased risk of cardiovascular morbidity and mortality.
PAD Binding (associated) of in lower limbs associated with atherosclerosis, disease and peripheral arterial disease
8) Confidence 0.41 Published 2006 Journal Atherosclerosis Section Abstract Doc Link 16386260 Disease Relevance 1.68 Pain Relevance 0.68
The recent Trans-Atlantic Inter-Society Consensus II update recommends the use of propionyl L-carnitine in combination with physical training to improve the symptoms associated with PAD.
PAD Binding (associated) of associated with peripheral arterial disease
9) Confidence 0.41 Published 2009 Journal Expert Opin Pharmacother Section Abstract Doc Link 19827991 Disease Relevance 1.11 Pain Relevance 0.40
At the multivariate analysis, smoking, diabetes and hypertension were significantly associated with PAD.
PAD Binding (associated) of associated with nicotine addiction, diabetes mellitus, hypertension and peripheral arterial disease
10) Confidence 0.41 Published 2004 Journal Atherosclerosis Section Abstract Doc Link 15186957 Disease Relevance 1.43 Pain Relevance 0.08
PAD is associated with reduced quality of life, and persons with PAD are also at risk of developing coronary artery disease and cerebrovascular disease.
PAD Binding (associated) of in coronary artery associated with cerebrovascular disease, coronary artery disease and peripheral arterial disease
11) Confidence 0.40 Published 2009 Journal J Vasc Nurs Section Abstract Doc Link 19486852 Disease Relevance 1.91 Pain Relevance 0.06
This Program demonstrated that individuals with PAD can be efficiently identified within the community, but that current standards of medical care are low.
PAD Binding (individuals) of associated with peripheral arterial disease
12) Confidence 0.37 Published 2001 Journal Vasc Med Section Abstract Doc Link 11530970 Disease Relevance 1.07 Pain Relevance 0.05
With a holistic approach to atherothrombotic vascular disease, our management of PAD can only get better.
PAD Binding (management) of associated with peripheral arterial disease and increased venous pressure under development
13) Confidence 0.37 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1166544 Disease Relevance 1.17 Pain Relevance 0.03
With a holistic approach to atherothrombotic vascular disease, our management of PAD can only get better.



PAD Binding (management) of associated with peripheral arterial disease and increased venous pressure under development
14) Confidence 0.37 Published 2005 Journal BMC Cardiovasc Disord Section Abstract Doc Link PMC1166544 Disease Relevance 1.14 Pain Relevance 0
CONCLUSION: The ABI identifies patients with asymptomatic PAD and those with atypical leg symptoms who are at risk for greater mobility decline than participants without PAD and participants with PAD with IC.


PAD Binding (identifies) of in leg
15) Confidence 0.32 Published 2010 Journal J Am Geriatr Soc Section Body Doc Link 20550604 Disease Relevance 0.10 Pain Relevance 0
CONCLUSION: The ABI identifies patients with asymptomatic PAD and those with atypical leg symptoms who are at risk for greater mobility decline than participants without PAD and participants with PAD with IC.


PAD Binding (identifies) of in leg
16) Confidence 0.32 Published 2010 Journal J Am Geriatr Soc Section Body Doc Link 20550604 Disease Relevance 0.10 Pain Relevance 0
The patients with PAD, and particularly those with critical ischemia, improve their symptoms when treated with angiogenic gene and cell therapy with acceptable tolerability.
PAD Binding (improve) of associated with ischemia and peripheral arterial disease
17) Confidence 0.32 Published 2009 Journal Heart Vessels Section Abstract Doc Link 19784813 Disease Relevance 1.03 Pain Relevance 0.15
We assessed the prevalence of and the factors associated with PAD and IC in the Spanish population.
PAD Binding (associated) of associated with restless leg syndrome and peripheral arterial disease
18) Confidence 0.31 Published 2009 Journal Int Angiol Section Abstract Doc Link 19190551 Disease Relevance 0.84 Pain Relevance 0.30
Statins not only lower the risk of vascular events, but they also improve the symptoms associated with PAD.
PAD Binding (associated) of associated with peripheral arterial disease
19) Confidence 0.31 Published 2007 Journal Arch. Med. Res. Section Abstract Doc Link 17560452 Disease Relevance 1.30 Pain Relevance 0.23
By now, PAD is well recognized as a marker of systemic atherosclerosis.
PAD Binding (recognized) of associated with atherosclerosis and peripheral arterial disease
20) Confidence 0.31 Published 2001 Journal Am. J. Cardiol. Section Abstract Doc Link 11434894 Disease Relevance 1.77 Pain Relevance 0.87

General Comments

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