INT39714

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Context Info
Confidence 0.59
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.47
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PGF) signal transduction (PGF) extracellular region (PGF)
cell-cell signaling (PGF)
Anatomy Link Frequency
platelet 2
decidua 2
endometrium 2
PGF (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 91.32 High High
antagonist 1 86.60 High High
Dismenorea 5 69.20 Quite High
agonist 8 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 91.08 High High
Body Weight 2 86.08 High High
Natriuresis 3 85.52 High High
Dysmenorrhea 3 46.28 Quite Low
Pre-term Labor 37 5.00 Very Low Very Low Very Low
Infection 11 5.00 Very Low Very Low Very Low
Premature Birth 10 5.00 Very Low Very Low Very Low
Bacterial Vaginosis 6 5.00 Very Low Very Low Very Low
Infant Respiratory Distress Syndrome 4 5.00 Very Low Very Low Very Low
Heart Rate Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Progesterone (1,000 ng/ml) markedly inhibited PGF secretion by proliferative but not secretory endometrium. 17 beta-estradiol and progesterone had no effect on prostaglandin E (PGE) secretion by both types of endometrium.
Negative_regulation (inhibited) of Localization (secretion) of PGF in endometrium
1) Confidence 0.59 Published 1982 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 7065034 Disease Relevance 0 Pain Relevance 0
Secretion of both PGF and PGE by proliferative and secretory endometria was inhibited by mefenamic acid ( 1 microgram/ml).
Negative_regulation (inhibited) of Localization (Secretion) of PGF
2) Confidence 0.38 Published 1982 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 7065034 Disease Relevance 0 Pain Relevance 0.07
Indomethacin had a greater effect than sulindac on the inhibition of collagen-induced platelet aggregation and thromboxane synthesis and the two drugs had equivalent effects on the reduction of PGF-M excretion.
Negative_regulation (reduction) of Localization (excretion) of PGF-M in platelet
3) Confidence 0.35 Published 1985 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 4028619 Disease Relevance 0.31 Pain Relevance 0.09
In addition, atosiban suppresses OT-mediated release of PGE and PGF from the decidua.79,80

Phase II and III studies

Negative_regulation (suppresses) of Localization (release) of PGF in decidua
4) Confidence 0.13 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2861440 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

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