INT39715

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Context Info
Confidence 0.41
First Reported 1985
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.22
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PGF) signal transduction (PGF) extracellular region (PGF)
cell-cell signaling (PGF)
Anatomy Link Frequency
plasma 1
skeletal muscle 1
platelet 1
PGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 4 95.96 Very High Very High Very High
cINOD 1 63.04 Quite High
ischemia 1 52.80 Quite High
COX2 1 25.00 Low Low
cOX1 1 25.00 Low Low
aspirin 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pre-eclampsia 100 97.72 Very High Very High Very High
Natriuresis 3 95.44 Very High Very High Very High
Cancer 1 86.56 High High
Hypertension 6 82.48 Quite High
Proteinuria 3 81.12 Quite High
INFLAMMATION 2 61.60 Quite High
Cv Unclassified Under Development 1 52.80 Quite High
Fibromyalgia 1 52.00 Quite High
Disease 16 7.28 Low Low
Insulin Resistance 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inconsistent and low levels of expression of the intron 1-retaining COX-1 variants suggest that these variants are not likely responsible for the inhibition of PGF(2alpha) production and skeletal muscle protein synthesis after resistance exercise by ibuprofen and acetaminophen.
Negative_regulation (inhibition) of PGF in skeletal muscle associated with paracetamol
1) Confidence 0.41 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17322116 Disease Relevance 0 Pain Relevance 0.22
Systemic effects were assessed by collagen-induced platelet aggregation and thromboxane B2 formation and by the urinary excretion of a systemically formed metabolite of PGF2 alpha (PGF-M).
Negative_regulation (metabolite) of PGF-M in platelet
2) Confidence 0.35 Published 1985 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 4028619 Disease Relevance 0.32 Pain Relevance 0.06
Similarly, maternal plasma levels of PlGF have been shown to be significantly reduced in the second trimester in women who went on to develop preeclampsia compared to controls (Kim et al. 2007).
Negative_regulation (reduced) of PlGF in plasma associated with pre-eclampsia
3) Confidence 0.23 Published 2008 Journal Trends Cardiovasc Med Section Body Doc Link PMC2577131 Disease Relevance 0.90 Pain Relevance 0.03

General Comments

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