INT39730

Context Info Confidence 0.75 First Reported 1985 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 5 Disease Relevance 2.40 Pain Relevance 0.59

unfolded protein binding (PFDN4) protein folding (PFDN4) cytosol (PFDN4) mitochondrion (PFDN4) nucleus (PFDN4) cytoplasm (PFDN4)

Anatomy Link Frequency BT-474 2 dorsal 1 ventral 1 PFDN4 (Homo sapiens)

Pain Link Frequency Relevance Heat Analgesic 6 88.12 rheumatoid arthritis 8 87.20 Pain 2 83.92 Antinociceptive 1 75.00 member 8 4 24.96 imagery 6 5.00 metalloproteinase 2 5.00 Kinase C 2 5.00

Disease Link Frequency Relevance Heat Dislocations 4 97.18 Breast Cancer 80 92.04 Nerve Compression Syndromes 2 90.08 INFLAMMATION 1 88.84 Rheumatoid Arthritis 8 87.20 Disease 6 86.88 Increased Venous Pressure Under Development 2 85.76 Pain 2 83.92 Spinal Cord Diseases 2 81.20 Death 2 77.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This consisted of vertical odontoid penetration through the foramen magnum (9 to 33 mm), occipito-atlanto-axial dislocation, lateral atlantal mass erosion, downward telescoping of the anterior arch of C-1 on the axis, and rostral rotation of the posterior arch of C-1 producing ventral and dorsal cervicomedullary junction compromise.

Gene_expression (producing) of C-1 in dorsal associated with dislocations

1) Confidence 0.75 Published 1985 Journal J. Neurosurg. Section Abstract Doc Link 4032013 Disease Relevance 1.00 Pain Relevance 0.20

Target compounds were synthesized in very good yields exploiting diphenylamine (7) as starting material, through regioselective functionalization of the C-1 position of 10H-phenothiazine ring.

Gene_expression (synthesized) of C-1

2) Confidence 0.65 Published 2004 Journal Bioorg. Med. Chem. Section Abstract Doc Link 15158783 Disease Relevance 0.09 Pain Relevance 0.19

The gene encoding prefoldin 4 (PFDN4) located within 20q13.11-13.32 has been shown to be overexpressed in those cell lines in which it is amplified, including BT-474 [18].

Gene_expression (overexpressed) of prefoldin 4 in BT-474

3) Confidence 0.65 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0.16 Pain Relevance 0

The gene encoding prefoldin 4 (PFDN4) located within 20q13.11-13.32 has been shown to be overexpressed in those cell lines in which it is amplified, including BT-474 [18].

Gene_expression (overexpressed) of PFDN4 in BT-474

4) Confidence 0.59 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0.16 Pain Relevance 0

This consisted of vertical odontoid penetration through the foramen magnum (9 to 33 mm), occipito-atlanto-axial dislocation, lateral atlantal mass erosion, downward telescoping of the anterior arch of C-1 on the axis, and rostral rotation of the posterior arch of C-1 producing ventral and dorsal cervicomedullary junction compromise.

Gene_expression (producing) of C-1 in ventral associated with dislocations

5) Confidence 0.26 Published 1985 Journal J. Neurosurg. Section Abstract Doc Link 4032013 Disease Relevance 1.00 Pain Relevance 0.20

General Comments

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