INT39733

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Context Info
Confidence 0.79
First Reported 1985
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 59
Total Number 59
Disease Relevance 22.76
Pain Relevance 13.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
Anatomy Link Frequency
monocytes 6
nucleus 5
T98G 1
osteoclast 1
vertex 1
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 33 99.84 Very High Very High Very High
Chronic pancreatitis 11 99.84 Very High Very High Very High
Substantia nigra 2 99.66 Very High Very High Very High
Inflammation 609 99.44 Very High Very High Very High
rheumatoid arthritis 165 99.28 Very High Very High Very High
cINOD 48 99.12 Very High Very High Very High
Paracetamol 12 99.12 Very High Very High Very High
narcan 1 99.04 Very High Very High Very High
cytokine 194 98.88 Very High Very High Very High
Serotonin 16 98.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 11 99.84 Very High Very High Very High
INFLAMMATION 790 99.44 Very High Very High Very High
Esophageal Cancer 5 99.42 Very High Very High Very High
Rheumatoid Arthritis 268 99.28 Very High Very High Very High
Apoptosis 258 98.88 Very High Very High Very High
Osteoporosis 109 98.40 Very High Very High Very High
Repression 17 97.08 Very High Very High Very High
Cancer 239 95.72 Very High Very High Very High
Adhesions 40 95.12 Very High Very High Very High
Retinal Diseases 2 92.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, these results indicate that anti-inflammatory drugs differ largely in their ability to inhibit NF-kappaB activity and/or TNF-alpha release from human monocytes.
Localization (release) of NF-kappaB in monocytes associated with inflammation and cinod
1) Confidence 0.79 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464079 Disease Relevance 0.62 Pain Relevance 0.46
Both stimuli induced NF-kappaB nuclear translocation and TNF-alpha secretion.
Localization (translocation) of NF-kappaB
2) Confidence 0.79 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464079 Disease Relevance 0.68 Pain Relevance 0.43
Salicylates have been shown to inhibit lipopolysaccharide-induced gene transcription via inhibition of NF-kappa B activation by preventing the degradation of NF-kappa B inhibitor "I kappa B", blocking the translocation of NF-kappa B into the nuclear compartment.
Localization (translocation) of NF-kappa B
3) Confidence 0.79 Published 1996 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 9467376 Disease Relevance 0.47 Pain Relevance 0.29
In parallel with transient NF-kappaB activation, the rapid translocation of NF-kappaB, particularly the p65 subunit, from the cytoplasm into the nucleus was demonstrated.
Localization (translocation) of NF-kappaB in nucleus
4) Confidence 0.77 Published 2007 Journal J. Dent. Res. Section Abstract Doc Link 17384033 Disease Relevance 0.55 Pain Relevance 0.37
These inhibitions appeared to correlate with the suppression of NF-kappaB activation by harpagoside, as pre-treating cells with harpagoside blocked the translocation of NF-kappaB into the nuclear compartments and degradation of the inhibitory subunit IkappaB-alpha.
Localization (translocation) of NF-kappaB
5) Confidence 0.77 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16203115 Disease Relevance 0.23 Pain Relevance 0.32
Capsaicin treatment of cells also blocked the degradation of I kappa B alpha, and thus the nuclear translocation of the p65 subunit of NF-kappa B, which is essential for NF-kappa B activation.
Localization (translocation) of NF-kappa B associated with qutenza
6) Confidence 0.75 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8906816 Disease Relevance 0.05 Pain Relevance 0.74
These changes correlate with a reduction in COX-2 mRNA and protein expression, prostaglandin synthesis, an inhibition of NF-kappaB nuclear translocation, and an increase in cytoplasmic IkappaB.
Localization (translocation) of NF-kappaB
7) Confidence 0.74 Published 2009 Journal Cancer Invest. Section Abstract Doc Link 19160097 Disease Relevance 0.66 Pain Relevance 0
IL-1beta-induced NF-kappaB activation was suppressed directly by cocktails of curcumin and resveratrol through inhibition of Ikappakappa and proteasome activation, inhibition of IkappaBalpha phosphorylation and degradation, and inhibition of nuclear translocation of NF-kappaB.
Localization (translocation) of NF-kappaB
8) Confidence 0.74 Published 2009 Journal Arthritis Res. Ther. Section Body Doc Link 19889203 Disease Relevance 0.05 Pain Relevance 0
Sickle monocytes triggered endothelial nuclear factor-kappa B (NF-kappaB) nuclear translocation.
Localization (translocation) of NF-kappaB in monocytes
9) Confidence 0.70 Published 2000 Journal Blood Section Abstract Doc Link 11001897 Disease Relevance 0.77 Pain Relevance 0.09
Both stimuli induced NF-kappaB nuclear translocation and TNF-alpha secretion.
Localization (secretion) of NF-kappaB
10) Confidence 0.69 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464079 Disease Relevance 0.69 Pain Relevance 0.43
We investigated the ability of dexamethasone, indomethacin, and rofecoxib to modulate nuclear factor-kappaB (NF-kappaB) activation and TNF-alpha release from human monocytes challenged with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA).
Localization (release) of NF-kappaB in monocytes associated with dexamethasone
11) Confidence 0.69 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464079 Disease Relevance 0.66 Pain Relevance 0.38
NS-398 induces apoptosis in human esophageal cancer cells through inhibition of NF-kappaB downstream regulation of cyclooxygenase-2.
Localization (regulation) of NF-kappaB associated with cox2, esophageal cancer and apoptosis
12) Confidence 0.69 Published 2009 Journal Cancer Invest. Section Title Doc Link 19160097 Disease Relevance 0.96 Pain Relevance 0.34
NFkappaB translocation at reperfusion was reduced in stable preconditioned and unstable control patients compared to stable controls.
Localization (translocation) of NFkappaB
13) Confidence 0.69 Published 2008 Journal Eur J Cardiothorac Surg Section Body Doc Link 18842422 Disease Relevance 0 Pain Relevance 0
Serotonin increased osteoprotegerin (OPG) and decreased receptor activator of NF-kappaB ligand (RANKL) secretion from osteoblasts, suggesting a role in osteoblast-induced inhibition of osteoclast differentiation, whereas fluoxetine had the opposite effect.
Localization (secretion) of NF-kappaB in osteoclast associated with osteoporosis, serotonin and fluoxetine
14) Confidence 0.68 Published 2006 Journal J. Cell. Biochem. Section Abstract Doc Link 16408289 Disease Relevance 0.15 Pain Relevance 1.00
Western blot analyses revealed that hCG-A impaired TNF-alpha-mediated phosphorylation and degradation of the inhibitor IkappaBalpha suggesting that the hormone may reduce nuclear import of NF-kappaB by stabilizing its inhibitor.
Localization (import) of NF-kappaB
15) Confidence 0.66 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.28 Pain Relevance 0.17
We have recently demonstrated that constitutively active nuclear factor-kappa B (NF-kappaB) is responsible for the increased secretion of uPA and that inhibition of NF-kappaB suppresses secretion of uPA and cell migration of highly invasive cancer cells.
Localization (secretion) of NF-kappaB associated with cancer
16) Confidence 0.65 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 14532966 Disease Relevance 0.96 Pain Relevance 0.27
We have recently demonstrated that constitutively active nuclear factor-kappa B (NF-kappaB) is responsible for the increased secretion of uPA and that inhibition of NF-kappaB suppresses secretion of uPA and cell migration of highly invasive cancer cells.
Localization (secretion) of nuclear factor-kappa B associated with cancer
17) Confidence 0.65 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 14532966 Disease Relevance 0.97 Pain Relevance 0.27
Resveratrol, like N-Ac-Leu-Leu-norleucinal (ALLN) suppressed IL-1beta-induced proteasome function and the degradation of IkappaBalpha (an inhibitor of NF-kappaB) without affecting IkappaBalpha kinase activation, IkappaBalpha-phosphorylation or IkappaBalpha-ubiquitination which suppressed nuclear translocation of the p65 subunit of NF-kappaB and its phosphorylation.
Localization (translocation) of NF-kappaB
18) Confidence 0.65 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18606398 Disease Relevance 0.98 Pain Relevance 0.34
HA also decreased the degree of phosphorylation and nuclear translocation of NF-kappaB enhanced by LPS.
Localization (translocation) of NF-kappaB
19) Confidence 0.65 Published 2010 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 20208419 Disease Relevance 0.48 Pain Relevance 0.38
We found that celecoxib and PSC833, but not indomethacin or NS398, almost completely inhibited basal- and dox induced NF-kappaB gene-reporter activity and p65 subunit nuclear translocation.
Localization (translocation) of NF-kappaB
20) Confidence 0.64 Published 2007 Journal Eur. J. Cancer Section Abstract Doc Link 17097285 Disease Relevance 0.06 Pain Relevance 0.12

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