INT39746

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Context Info
Confidence 0.03
First Reported 1983
Last Reported 1985
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 6
Disease Relevance 1.31
Pain Relevance 6.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Rnf14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 86 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nephrotoxicity 10 87.36 High High
Sprains And Strains 2 84.72 Quite High
Necrosis 5 73.32 Quite High
Kidney Cortex Necrosis 6 71.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Combination of these subcellular fractions resulted in greater covalent binding of [ring-14C]APAP than in the individual subcellular fractions alone.
ring-14C Binding (binding) of associated with paracetamol
1) Confidence 0.03 Published 1983 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 6636173 Disease Relevance 0.19 Pain Relevance 1.03
In contrast, NADPH-independent covalent binding of [ring-14C]APAP could not be demonstrated in any combination of hepatic subcellular fractions.
ring-14C Binding (binding) of associated with paracetamol
2) Confidence 0.03 Published 1983 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 6636173 Disease Relevance 0.07 Pain Relevance 0.93
Covalent binding of [ring-14C]APAP to renal subcellular fractions was used to substantiate this hypothesis.
ring-14C Binding (binding) of associated with paracetamol
3) Confidence 0.03 Published 1983 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 6636173 Disease Relevance 0.22 Pain Relevance 0.87
Under appropriate incubation conditions, enzymatic NADPH-independent covalent binding of [ring-14C]APAP could be demonstrated in renal microsomes but not in 100,000g supernatant fractions.
ring-14C Binding (binding) of associated with paracetamol
4) Confidence 0.03 Published 1983 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 6636173 Disease Relevance 0.21 Pain Relevance 0.98
Experiments comparing [ring-14C]APAP and [acetyl-14C]APAP covalent binding to renal 10,000g supernatant fractions indicate that the compound which binds to renal macromolecules is derived from PAP.
ring-14C Binding (binding) of associated with paracetamol
5) Confidence 0.03 Published 1983 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 6636173 Disease Relevance 0.07 Pain Relevance 0.93
Furthermore, covalent binding of [ring-14C]APAP to renal cortical protein was approximately four times greater in F344 rats than in SD rats.
ring-14C Binding (binding) of associated with paracetamol
6) Confidence 0.01 Published 1985 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 4035671 Disease Relevance 0.54 Pain Relevance 1.29

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