INT39758

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Context Info
Confidence 0.65
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 57
Total Number 58
Disease Relevance 34.38
Pain Relevance 6.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fn1) cell adhesion (Fn1) proteinaceous extracellular matrix (Fn1)
extracellular matrix organization (Fn1)
Anatomy Link Frequency
extracellular matrix 7
epithelial cells 5
ASM 3
fibroblasts 2
lung 2
Fn1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 54 100.00 Very High Very High Very High
COX2 21 99.56 Very High Very High Very High
cytokine 143 99.28 Very High Very High Very High
fibrosis 403 99.08 Very High Very High Very High
agonist 78 98.64 Very High Very High Very High
Inflammation 539 98.60 Very High Very High Very High
Action potential 92 98.38 Very High Very High Very High
dorsal root ganglion 36 97.20 Very High Very High Very High
imagery 169 93.96 High High
Central nervous system 23 93.92 High High
Disease Link Frequency Relevance Heat
Myocardial Infarction 17 100.00 Very High Very High Very High
Lung Cancer 307 99.96 Very High Very High Very High
Primary Sclerosing Cholangitis 3 99.84 Very High Very High Very High
Breast Cancer 40 99.80 Very High Very High Very High
Hypertrophy 11 99.70 Very High Very High Very High
Cyst 1 99.70 Very High Very High Very High
Wound Healing 87 99.66 Very High Very High Very High
Cicatrix 65 99.52 Very High Very High Very High
Asthma 559 99.16 Very High Very High Very High
Hyperplasia 15 99.10 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Animal experiments have shown antiatherosclerotic effects with ezetimibe therapy, in part possibly mediated by nonlipid (pleiotropic) mechanisms, the significance of which is controversial.62–68 In apoE knockout (ko) mice, aortic lesion formation was significantly reduced by ezetimibe therapy.62 Ezetimibe treatment resulted in a significant reduction in plaque size and macrophage and fibronectin extra domain-B immunoreactivity in brachiocephalic lesions, indicating plaque regression.66 Similar results were also shown with high-intensity (7 T) magnetic resonance imaging.63
Gene_expression (macrophage) of fibronectin in plaque associated with targeted disruption, atherosclerosis and imagery
1) Confidence 0.65 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.48 Pain Relevance 0.05
ON/OFF patterns of FN1-SPP1 (Fig. 6A) and IGF1-SPP1 (Fig. 6B) were observed in the data gathered in experiments exposing normal human bronchial epithelial cells to cigarette smoke.
Gene_expression (patterns) of FN1 in epithelial cells
2) Confidence 0.65 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2900289 Disease Relevance 0.93 Pain Relevance 0.10
Fibronectin messenger RNA expression was significantly higher in this group.
Gene_expression (expression) of Fibronectin
3) Confidence 0.59 Published 1996 Journal Gastroenterology Section Body Doc Link 8566606 Disease Relevance 0.14 Pain Relevance 0
Expression of pancreatic fibronectin messenger RNA was also examined in both groups.
Spec (examined) Gene_expression (Expression) of fibronectin
4) Confidence 0.59 Published 1996 Journal Gastroenterology Section Body Doc Link 8566606 Disease Relevance 0.17 Pain Relevance 0
These studies revealed significant induction of HIF-1-target genes (VEGF, CD73 or FN1) in control cells, while these responses were abolished in HIF-1?
Gene_expression (genes) of FN1
5) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.05 Pain Relevance 0.03
In this study, we showed that SPC-A-1sci cells express higher level of fibronectin, and down-regulation of which can significantly decrease both the in vitro and in vivo metastatic abilities of those cells.
Gene_expression (express) of fibronectin
6) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912267 Disease Relevance 0.38 Pain Relevance 0
In contrast, the expression of mesenchymal markers, including vimentin and fibronectin, whose expression has been shown to positively correlate with the EMT, was strongly increased in SPC-A-1sci cells (Fig. 2B-D).
Gene_expression (expression) of fibronectin
7) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912267 Disease Relevance 0.32 Pain Relevance 0
In contrast, the expression of mesenchymal markers, including vimentin and fibronectin, whose expression has been shown to positively correlate with the EMT, was strongly increased in SPC-A-1sci cells (Fig. 2B-D).
Gene_expression (expression) of fibronectin
8) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912267 Disease Relevance 0.32 Pain Relevance 0
For experimental metastasis in vivo, SPC-A-1sci cells (2 × 106 per mouse) stably expressing shRNA against fibronectin or negative control were injected into the tail vein of NOD/SCID mice (n = 8).
Gene_expression (expressing) of fibronectin in tail vein associated with severe combined immunodeficiency and metastasis
9) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912267 Disease Relevance 0.49 Pain Relevance 0.11
Compared to cells from AD patients, control cells up-regulated (>2.2-fold) the transcription of 35 genes and expressed sequence tags (ESTs), including MGAT3 (327-fold, P < 0.001), and the genes encoding fibronectin (FN1; 10.1-fold, P < 0.001), cholinergic receptor, muscarinic 4 (9.3-fold, P < 0.001), and 2'-5'-oligoadenylate synthetase 3 (OAS; 7.8-fold, P < 0.001), and down-regulated (>2-fold) the transcription of an additional 35 genes or ESTs.
Gene_expression (expressed) of fibronectin associated with disease
10) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604897 Disease Relevance 0.69 Pain Relevance 0
Compared to cells from AD patients, control cells up-regulated (>2.2-fold) the transcription of 35 genes and expressed sequence tags (ESTs), including MGAT3 (327-fold, P < 0.001), and the genes encoding fibronectin (FN1; 10.1-fold, P < 0.001), cholinergic receptor, muscarinic 4 (9.3-fold, P < 0.001), and 2'-5'-oligoadenylate synthetase 3 (OAS; 7.8-fold, P < 0.001), and down-regulated (>2-fold) the transcription of an additional 35 genes or ESTs.
Gene_expression (expressed) of FN1 associated with disease
11) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604897 Disease Relevance 0.69 Pain Relevance 0
Thus, we measured transcript levels of CD73 [62], VEGF [63], Fibronectin1 (FN1) [64] and COX2 [65] after 24 h of RSV infection of A549 pulmonary epithelial cells using different RSV infection doses (MOI1-5).
Gene_expression (levels) of Fibronectin1 in epithelial cells associated with cox2, infection and respiratory syncytial virus
12) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.79 Pain Relevance 0.09
Thus, we measured transcript levels of CD73 [62], VEGF [63], Fibronectin1 (FN1) [64] and COX2 [65] after 24 h of RSV infection of A549 pulmonary epithelial cells using different RSV infection doses (MOI1-5).
Gene_expression (levels) of FN1 in epithelial cells associated with cox2, infection and respiratory syncytial virus
13) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.80 Pain Relevance 0.09
In conclusion, we have identified a subset of genes with increased expression in noninfarcted left ventricular tissue following MI, including syndecans 1-4, WT-1, fibronectin, collagen 6A, and FGF receptor 1.
Gene_expression (expression) of fibronectin associated with myocardial infarction
14) Confidence 0.30 Published 2004 Journal Physiol. Genomics Section Abstract Doc Link 14625378 Disease Relevance 0.53 Pain Relevance 0.07
In vitro, TGF-beta1 stimulated collagen type I expression but not fibronectin expression in PSC, in contrast to FGF-2, which stimulated both.
Gene_expression (expression) of fibronectin in PSC associated with primary sclerosing cholangitis
15) Confidence 0.30 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11123210 Disease Relevance 0.90 Pain Relevance 0.19
Detection of extracellular matrix protein fibronectin
Gene_expression (Detection) of fibronectin in extracellular matrix
16) Confidence 0.30 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.09 Pain Relevance 0.13
Fibronectin was also commonly present on the articular surface of specimens from old animals.
Gene_expression (present) of Fibronectin in articular
17) Confidence 0.28 Published 1985 Journal Arthritis Rheum. Section Abstract Doc Link 4038356 Disease Relevance 0.43 Pain Relevance 0.15
Detection of fibulin-1 and fibronectin in airway smooth muscle cells
Gene_expression (Detection) of fibronectin in smooth muscle cells
18) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0 Pain Relevance 0
In order to confirm the direct effects of fibronectin on cell migration and invasion of SPC-A-1sci cells, we used shRNA to knockdown the expression of fibronectin (Fig. 4B) and then measured the migratory and invasive abilities of SPC-A-1sci cells by trans-well assays.
Gene_expression (expression) of fibronectin
19) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912267 Disease Relevance 0.19 Pain Relevance 0
In lung cancer, fibronectin expression is increased and has been implicated in promoting lung cancer growth and conferring resistance to therapy [11,12].
Gene_expression (expression) of fibronectin in lung associated with lung cancer
20) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912267 Disease Relevance 1.63 Pain Relevance 0

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