INT3979

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Context Info
Confidence 0.45
First Reported 1976
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.49
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PIK3C2A) plasma membrane (PIK3C2A) nucleus (PIK3C2A)
cytoplasm (PIK3C2A)
PIK3C2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 99.90 Very High Very High Very High
headache 3 88.88 High High
Potency 2 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 10 100.00 Very High Very High Very High
Headache 3 88.88 High High
Vomiting 4 87.72 High High
Diarrhoea 3 86.80 High High
Hepatitis 1 86.56 High High
Infection 4 84.64 Quite High
Pain 1 80.72 Quite High
Disease 1 70.44 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 46 70.12 Quite High
Disorder Of Lipid Metabolism 1 58.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intramuscular injection of both the drug solution and its solvent was painful and caused CPK elevations.
Positive_regulation (caused) of Positive_regulation (elevations) of CPK associated with pain and disorders of creatine metabolism
1) Confidence 0.45 Published 1976 Journal J Clin Pharmacol Section Abstract Doc Link 943424 Disease Relevance 0.53 Pain Relevance 0.18
However, three laboratory adverse events were reported more frequently in patients in the raltegravir groups compared to patients in the placebo groups: elevations of ALT (4.5% vs 2.1%); elevations of AST (4.3% vs 2.5%); elevations of creatine phosphokinase (CPK) (3.2% vs 0.7%).
Positive_regulation (elevations) of Positive_regulation (elevations) of CPK associated with disorders of creatine metabolism
2) Confidence 0.16 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504063 Disease Relevance 0.95 Pain Relevance 0.09

General Comments

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