INT398

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Context Info
Confidence 0.78
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 45
Total Number 45
Disease Relevance 16.97
Pain Relevance 11.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGT) small molecule metabolic process (AGT) aging (AGT)
extracellular region (AGT) extracellular matrix organization (AGT) cell-cell signaling (AGT)
Anatomy Link Frequency
brain 2
blood 2
melanocyte 2
heart 2
corpus 2
AGT (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 117 100.00 Very High Very High Very High
Neuropeptide 38 100.00 Very High Very High Very High
substance P 27 100.00 Very High Very High Very High
Catecholamine 19 100.00 Very High Very High Very High
noradrenaline 17 100.00 Very High Very High Very High
Enkephalin 12 100.00 Very High Very High Very High
Opioid 9 100.00 Very High Very High Very High
Dynorphin 7 100.00 Very High Very High Very High
calcitonin gene related peptide 2 100.00 Very High Very High Very High
Nicotine 2 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 231 100.00 Very High Very High Very High
Natriuresis 7 100.00 Very High Very High Very High
Adenoma 4 100.00 Very High Very High Very High
Stress 116 99.62 Very High Very High Very High
Pituitary Cancer 2 99.32 Very High Very High Very High
Rheumatoid Arthritis 131 98.96 Very High Very High Very High
Sprains And Strains 2 98.88 Very High Very High Very High
Obesity 34 98.80 Very High Very High Very High
Apoptosis 122 98.52 Very High Very High Very High
Atherosclerosis 87 98.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The endothelial cell releases angiotensin-II (AII) as an antagonist of NO by means of hydrolyzing angiotensin-I by angiotensine converting enzyme (ACE).
Localization (releases) of angiotensin-II in endothelial cell associated with antagonist
1) Confidence 0.78 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1434727 Disease Relevance 1.31 Pain Relevance 0.31
Stretching of myocytes leads to release of angiotensin, which is known to induce a hypertrophic response in the myocyte through autocrine/paracrine effects.
Localization (release) of angiotensin in myocyte
2) Confidence 0.78 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2862957 Disease Relevance 0.07 Pain Relevance 0.08
Greater receptor affinity to various pressor neuropeptides such as angiotensin and leucine enkephalin or greater release of these peptides may also account for the excessive CNS sympathetic activation or impairment of baroreflexes at a central level.
Localization (release) of angiotensin in sympathetic associated with neuropeptide and enkephalin
3) Confidence 0.73 Published 1982 Journal Hypertension Section Abstract Doc Link 7040239 Disease Relevance 0.54 Pain Relevance 0.24
The peptide classes studied were angiotensin, bradykinin, alpha-bag cell factor, beta,gamma-bag cell factor, beta-casomorphin, dynorphin, enkephalin, leucokinin, lutinizing hormone releasing hormone, neurotinsin, substance P, and vasopressin.
Localization (releasing) of angiotensin associated with dynorphin, enkephalin, bradykinin and substance p
4) Confidence 0.68 Published 2004 Journal J Chromatogr A Section Abstract Doc Link 15543975 Disease Relevance 0 Pain Relevance 0.25
This culminates in angiotensin production, norepinephrine release, and arrhythmic cardiac dysfunction.
Localization (release) of angiotensin
5) Confidence 0.68 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20668055 Disease Relevance 0.23 Pain Relevance 0.55
In the present study we examined the possibility that angiotensin II, acting in brain, modulates endorphin-induced catecholamine secretion.
Localization (secretion) of angiotensin II in brain associated with catecholamine
6) Confidence 0.67 Published 1983 Journal Peptides Section Abstract Doc Link 6306616 Disease Relevance 0 Pain Relevance 0.46
It is still under debate whether angiotensin II facilitates noradrenaline release in the heart.
Localization (release) of angiotensin II in heart associated with noradrenaline
7) Confidence 0.56 Published 1997 Journal Acta Physiol. Scand. Section Abstract Doc Link 9381945 Disease Relevance 0.17 Pain Relevance 0.18
Serial sections were immunostained by antisera of 14 different neuropeptides--oxytocin, vasopressin, thyrotropin-releasing hormone, angiotensin II, calcitonin gene-related peptide, beta-endorphin, dynorphin A, dynorphin B, leucine-enkephalin, alpha-melanocyte stimulating hormone, substance P, neuropeptide Y, cholecystokinin and galanin--alternately.
Localization (releasing) of angiotensin II in melanocyte associated with dynorphin, neuropeptide, enkephalin, cholecystokinin, substance p and calcitonin gene-related peptide
8) Confidence 0.49 Published 1992 Journal Neuroscience Section Abstract Doc Link 1542421 Disease Relevance 0 Pain Relevance 0.86
Bradykinin and angiotensin II inhibit neurotransmission in rabbit ear artery by releasing prostanoids.
Localization (releasing) of angiotensin II in artery associated with bradykinin
9) Confidence 0.49 Published 1991 Journal Eur. J. Pharmacol. Section Title Doc Link 1655480 Disease Relevance 0 Pain Relevance 0.37
Neuropeptides like substance P, dynorphin A and B, cholecystokinin, galanin, corticotropin-releasing factor, thyrotropin-releasing hormone, angiotensin II and neurotensin showed no immunoreactivity in the human superior cervical ganglion.
Localization (releasing) of angiotensin II in superior cervical ganglion associated with ganglion cysts, dynorphin, neuropeptide, cholecystokinin and substance p
10) Confidence 0.39 Published 1992 Journal Brain Res. Section Abstract Doc Link 1352173 Disease Relevance 0.41 Pain Relevance 0.59
Angiotensin I and II were measured by a standard radioimmunoassay (Peninsula Laboratories, St.
Localization (measured) of Angiotensin
11) Confidence 0.38 Published 2010 Journal Nutr J Section Body Doc Link PMC2989300 Disease Relevance 0.75 Pain Relevance 0.08
Many factors may be incriminated: lowered blood pressure and cardiac output, increased sympathetic outflow (renal nerve stimulation and increased plasma catecholamines), increased release of renin, angiotensin and vasopressin.
Localization (release) of angiotensin in outflow associated with pressure volume 2 under development and catecholamine
12) Confidence 0.36 Published 1990 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 2278418 Disease Relevance 0.10 Pain Relevance 0.12
Angiotensin II (AT II) has a direct stimulating action on CRH and vasopressin release from the hypothalamus [18,19]. 4.
Localization (release) of Angiotensin II in hypothalamus
13) Confidence 0.34 Published 2003 Journal BMC Psychiatry Section Body Doc Link PMC280657 Disease Relevance 0.30 Pain Relevance 0.29
This review is focused on peptide fragments released from opioid related peptides, substance P and angiotensin II, that have been shown to modulate the action of their parent compounds.
Localization (released) of angiotensin II associated with opioid and substance p
14) Confidence 0.34 Published 2007 Journal Curr Drug Targets Section Abstract Doc Link 17266538 Disease Relevance 0 Pain Relevance 0.30
Oxidative stress, but not hormones released during labor such as prostaglandin E1, oxytocin or angiotensin II, induces the expression of Mst3 and apoptosis of human term placenta after elective Cesarean section without labor pain.
Localization (released) of angiotensin II in placenta associated with stress, pain labor and apoptosis
15) Confidence 0.33 Published 2008 Journal Apoptosis Section Abstract Doc Link 18040775 Disease Relevance 0.96 Pain Relevance 0.10
In animal models, ACE-I can retard the development of atherosclerosis, and these antiatherogenic properties can be related to the inhibition of angiotensin-II (Ang II) formation and to the inhibition of bradykinin degradation, which promotes vasodilatation by stimulating the production of arachidonic acid metabolites and nitric oxide (NO) in vascular endothelium.
Localization (formation) of angiotensin-II in vascular endothelium associated with atherosclerosis, increased venous pressure under development and bradykinin
16) Confidence 0.20 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.95 Pain Relevance 0.15
Electrical properties of cultured human adrenocorticotropin-secreting adenoma cells: effects of high K+, corticotropin-releasing factor, and angiotensin II.
Localization (secreting) of angiotensin II associated with adenoma
17) Confidence 0.19 Published 1987 Journal Endocrinology Section Title Doc Link 3036472 Disease Relevance 0.39 Pain Relevance 0.12
The cells responded to factors known to stimulate ACTH release, including high K+, CRF, and angiotensin II (AII).
Localization (release) of angiotensin II
18) Confidence 0.19 Published 1987 Journal Endocrinology Section Abstract Doc Link 3036472 Disease Relevance 0.31 Pain Relevance 0.14
We will discuss the stimulatory actions of neuropeptide Y (NPY), angiotensin II, and peptides of immune cell origin on the secretion of ACTH and CRH.
Localization (secretion) of angiotensin II in immune cell associated with neuropeptide
19) Confidence 0.18 Published 1989 Journal Toxicol Pathol Section Abstract Doc Link 2571183 Disease Relevance 0 Pain Relevance 0.60
In the isolated perfused rabbit kidney, indomethacin inhibited the basal efflux of all fatty acids as well as the angiotensin II--induced selective release off arachidonate.
Localization (release) of angiotensin II in kidney
20) Confidence 0.17 Published 1980 Journal Prostaglandins Section Abstract Doc Link 7465862 Disease Relevance 0.13 Pain Relevance 0.33

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