INT3982

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Context Info
Confidence 0.56
First Reported 1976
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 53
Total Number 54
Disease Relevance 7.61
Pain Relevance 10.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
amacrine cells 5
brain 3
lymphocytes 3
neurons 3
fibroblasts 2
Acot1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 175 100.00 Very High Very High Very High
Neurotransmitter 168 100.00 Very High Very High Very High
calcitonin gene related peptide 8 100.00 Very High Very High Very High
Catecholamine 28 99.28 Very High Very High Very High
Neuropeptide 19 98.92 Very High Very High Very High
agonist 272 98.60 Very High Very High Very High
addiction 28 98.60 Very High Very High Very High
tolerance 3 98.00 Very High Very High Very High
Serotonin 32 97.92 Very High Very High Very High
Morphine 5 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 5 99.74 Very High Very High Very High
Disease 759 99.68 Very High Very High Very High
Ganglion Cysts 236 96.96 Very High Very High Very High
Clostridium Infection 20 95.20 Very High Very High Very High
Increased Venous Pressure Under Development 61 92.04 High High
Cognitive Disorder 140 91.68 High High
Breast Cancer 5 91.12 High High
Prion Diseases 80 88.92 High High
Proteostasis Deficiencies 7 88.60 High High
Targeted Disruption 148 87.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Addition of veratridine (1.5 microM) either to explant or to dissociated cell cultures of embryonic quail sympathetic ganglia barely altered CA-synthesizing ability; in contrast, ACh synthesis and accumulation were stimulated about threefold.
Gene_expression (synthesis) of ACh in ganglia associated with catecholamine
1) Confidence 0.56 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 8455211 Disease Relevance 0 Pain Relevance 0.39
The early expression of the cholinergic phenotype appears to be species-specific in that, under identical conditions, dissociated cell cultures of newborn mouse superior cervical ganglia were overwhelmingly catecholaminergic (CA:ACh ratio of approximately 40:1) and ACh synthesis was only just detectable.
Gene_expression (synthesis) of ACh in superior associated with catecholamine
2) Confidence 0.56 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 8455211 Disease Relevance 0 Pain Relevance 0.40
Brain acetylcholine (ACh) levels in both N and M mice were increased by physostigmine, the increase being greater in M mice.
Gene_expression (levels) of ACh in Brain
3) Confidence 0.51 Published 1976 Journal Eur. J. Pharmacol. Section Abstract Doc Link 944135 Disease Relevance 0.07 Pain Relevance 1.01
If the ganglia were dissociated before plating, there was a selective increase in ACh synthesis (three- to fivefold) such that the CA:ACh ratio fell strikingly.
Gene_expression (synthesis) of ACh in ganglia associated with catecholamine
4) Confidence 0.49 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 8455211 Disease Relevance 0 Pain Relevance 0.34
A preferential stimulation of ACh production was also observed when the concentration of K+ was raised to 20 mM.
Gene_expression (production) of ACh
5) Confidence 0.49 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 8455211 Disease Relevance 0 Pain Relevance 0.35
Consistent with this assumption, the respiratory epithelium contains ACh, its synthesizing enzyme, and the high-affinity choline transporter CHT1 (Reinheimer et al., 1996; Pfeil et al., 2003; Proskocil et al., 2004).
Gene_expression (synthesizing) of ACh in epithelium
6) Confidence 0.49 Published 2006 Journal J. Mol. Neurosci. Section Abstract Doc Link 17192631 Disease Relevance 0 Pain Relevance 0.22
The expression of CTE-I can be induced by fasting; that is the expression is increased during the light phase and declined during the dark phase when feeding activity is abundant [44].
Gene_expression (expression) of CTE-I
7) Confidence 0.32 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.13 Pain Relevance 0.03
To investigate contribution made by the high-affinity choline transporter (CHT1) to ACh synthesis in both cholinergic neurons and nonneuronal cells, we transfected rat CHT1 cDNA into NIH3T3ChAT cells, a mouse fibroblast line expressing mouse choline acetyltransferase (ChAT), to establish the NIH3T3ChAT 112-1 cell line, which stably expresses both CHT1 and ChAT.
Gene_expression (synthesis) of ACh in fibroblast
8) Confidence 0.25 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19405101 Disease Relevance 0 Pain Relevance 0.04
These results suggest that CHT1 plays a key role in ACh synthesis in NIH3T3ChAT 112-1 cells and that choline taken up by OCTs or derived from the plasma membrane is also utilized for ACh synthesis in both cholinergic neurons and nonneuronal cholinergic cells, such as lymphocytes.
Gene_expression (synthesis) of ACh in lymphocytes
9) Confidence 0.25 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19405101 Disease Relevance 0 Pain Relevance 0.18
HC-3 significantly inhibited ACh synthesis in NIH3T3ChAT 112-1 cells but did not affect synthesis in NIH3T3ChAT 103-1 cells.
Gene_expression (synthesis) of ACh
10) Confidence 0.25 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19405101 Disease Relevance 0 Pain Relevance 0.19
ACh synthesis in NIH3T3ChAT 112-1 cells was also reduced by amiloride, an inhibitor of organic cation transporters (OCTs) involved in low-affinity choline uptake, and by procaine and lidocaine, two local anesthetics that inhibit plasma membrane phospholipid metabolism.
Gene_expression (synthesis) of ACh in plasma associated with lidocaine and local anesthetic
11) Confidence 0.22 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19405101 Disease Relevance 0 Pain Relevance 0.22
NIH3T3ChAT 112-1 cells showed increased binding of the CHT1 inhibitor [(3)H]hemicholinium-3 (HC-3) and greater [(3)H]choline uptake and ACh synthesis than NIH3T3ChAT 103-1 cells, a CHT1-negative control cell line.
Gene_expression (synthesis) of ACh
12) Confidence 0.22 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19405101 Disease Relevance 0 Pain Relevance 0.17
These results suggest that CHT1 plays a key role in ACh synthesis in NIH3T3ChAT 112-1 cells and that choline taken up by OCTs or derived from the plasma membrane is also utilized for ACh synthesis in both cholinergic neurons and nonneuronal cholinergic cells, such as lymphocytes.
Gene_expression (synthesis) of ACh in lymphocytes
13) Confidence 0.22 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19405101 Disease Relevance 0 Pain Relevance 0.19
A stable cell line expressing mouse acetylcholine receptors (AChRs), named AM4, was established by cotransfecting into NIH 3T3 fibroblasts, alpha-, beta-, gamma-, and delta-subunit cDNAs plus the neor gene by calcium phosphate precipitation.
Gene_expression (expressing) of AChRs in fibroblasts
14) Confidence 0.19 Published 1991 Journal J. Biol. Chem. Section Abstract Doc Link 1713208 Disease Relevance 0 Pain Relevance 0
Importantly, in the absence of AChE, the levels of extracellular ACh in the brain are controlled by the activity of BChE.
Gene_expression (levels) of ACh in brain
15) Confidence 0.18 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17212694 Disease Relevance 0 Pain Relevance 0.10
Acetylcholine (ACh) is known to be a key neurotransmitter in the central and peripheral nervous systems, but it is also produced in a variety of non-neuronal tissues and cells, including lymphocytes, placenta, amniotic membrane, vascular endothelial cells, keratinocytes, and epithelial cells in the digestive and respiratory tracts.
Gene_expression (produced) of ACh in lymphocytes associated with neurotransmitter
16) Confidence 0.17 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19405101 Disease Relevance 0 Pain Relevance 0.05
The released Ach and CGRP excite the ascending and descending interneurons, which in turn release Ach at their terminals.
Gene_expression (excite) of Ach in interneurons associated with calcitonin gene related peptide
17) Confidence 0.14 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503665 Disease Relevance 0.07 Pain Relevance 0.60
The SCCs are capable of synthesizing and packaging acetylcholine (ACh)
Gene_expression (synthesizing) of ACh
18) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0.07 Pain Relevance 0.07
Using focal extracellular recording, capable of detecting the effects of a single ACh quantum with a spatial resolution of less than 10 ?
Gene_expression (quantum) of ACh
19) Confidence 0.10 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538785 Disease Relevance 0.07 Pain Relevance 0.03
A participation of RhoA-mediated Ca2+ sensitization in the augmented ACh-induced contraction of BSM was demonstrated in this animal model of AHR.


Gene_expression (contraction) of ACh-induced in BSM
20) Confidence 0.10 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0.39 Pain Relevance 0.07

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