INT3983

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Context Info
Confidence 0.68
First Reported 1976
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 30
Total Number 34
Disease Relevance 5.83
Pain Relevance 8.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
brain 4
reticular formation 2
hippocampus 2
smooth muscle 1
muscle 1
Acot1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 16 100.00 Very High Very High Very High
Neurotransmitter 15 99.84 Very High Very High Very High
Antinociceptive 3 99.60 Very High Very High Very High
fluoxetine 6 99.28 Very High Very High Very High
tetrodotoxin 20 99.08 Very High Very High Very High
monoamine 9 98.88 Very High Very High Very High
diclofenac 44 98.82 Very High Very High Very High
Sumatriptan 8 98.68 Very High Very High Very High
addiction 6 98.60 Very High Very High Very High
tolerance 4 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 135 99.52 Very High Very High Very High
Increased Venous Pressure Under Development 7 94.00 High High
Disease 149 93.00 High High
Hypertension 13 91.72 High High
Asthma 40 91.28 High High
Injury 48 90.68 High High
Congenital Myasthenic Syndromes 6 90.08 High High
Necrosis 7 87.92 High High
Cognitive Disorder 11 87.76 High High
Cancer 8 87.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sumatriptan, administered in the range of antinociceptive doses, was able to increase the level of ACh present in extracellular hippocampal space.
Positive_regulation (increase) of ACh associated with sumatriptan and antinociceptive
1) Confidence 0.68 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8930196 Disease Relevance 0.20 Pain Relevance 1.44
Nitric oxide (NO)-releasing beads microinjected into the pontine reticular formation of C57BL/6J (B6) mice significantly (P < 0.0001) increased ACh release.
Positive_regulation (increased) of ACh in reticular formation
2) Confidence 0.48 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16424074 Disease Relevance 0 Pain Relevance 0
Both high K+ and veratridine, depolarizing agents with different mechanisms of action, lowered the ACh content of the cytoplasmic (S3) fraction of mouse forebrain minces incubated in a Ca2+-free Krebs solution, without stimulating ACh release or altering the level of ACh in the vesicle-bound (P3) fraction.
Neg (without) Positive_regulation (stimulating) of ACh in vesicle
3) Confidence 0.48 Published 1984 Journal Brain Res. Section Abstract Doc Link 6697191 Disease Relevance 0 Pain Relevance 0.08
The action of TEA was different from that of 5-HT; potentiation of responses was greater than could be produced by 5-HT, and whereas 5-HT did not increase responses to ACh, TEA markedly increased twitch tensions.
Neg (not) Positive_regulation (increase) of ACh
4) Confidence 0.43 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2996910 Disease Relevance 0 Pain Relevance 0.07
Brain acetylcholine (ACh) levels in both N and M mice were increased by physostigmine, the increase being greater in M mice.
Positive_regulation (increased) of ACh in Brain
5) Confidence 0.40 Published 1976 Journal Eur. J. Pharmacol. Section Abstract Doc Link 944135 Disease Relevance 0.07 Pain Relevance 1.02
Microdialysis delivery of the NO donor N-ethyl-2-(1-ethyl-2-hydroxy-2-nitrosohydrazino)-ethanamine (NOC-12) to the mouse pontine reticular formation also caused a concentration-dependent increase in ACh release (P < 0.001).
Positive_regulation (increase) of ACh in reticular formation
6) Confidence 0.39 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16424074 Disease Relevance 0 Pain Relevance 0.05
When the cytoplasmic level of ACh is sufficiently elevated prior to depolarization, then some ACh escapes hydrolysis and is released independently of Ca2+.
Positive_regulation (elevated) of ACh
7) Confidence 0.39 Published 1984 Journal Brain Res. Section Abstract Doc Link 6697191 Disease Relevance 0 Pain Relevance 0.06
Like phencyclidine, beta-eudesmol blocked the nicotinic ACh receptor channel in both the open and closed conformations, and accelerated the desensitization of the nicotinic ACh receptor.
Positive_regulation (accelerated) of ACh receptor
8) Confidence 0.38 Published 1991 Journal Neuropharmacology Section Abstract Doc Link 1780041 Disease Relevance 0 Pain Relevance 0.03
Infusion of scopolamine (1 microM) caused a fivefold increase of ACh levels in wild-type animals but only a 50% increase in AChE-deficient mice.
Positive_regulation (increase) of ACh
9) Confidence 0.31 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 18023504 Disease Relevance 0 Pain Relevance 0.16
Using microdialysis, we found that increased ACh levels are accompanied by decreased levels of extracellular choline which were 1.60 microM in AChE-deficient mice and 4.36 microM in wild-type mice.
Positive_regulation (increased) of ACh
10) Confidence 0.27 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 18023504 Disease Relevance 0 Pain Relevance 0.08
High levels of extracellular ACh are accompanied by reduced levels of extracellular choline, and ACh release becomes strongly dependent on choline availability.
Positive_regulation (levels) of ACh
11) Confidence 0.27 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 18023504 Disease Relevance 0 Pain Relevance 0.13
Mice deficient for acetylcholinesterase (AChE) have strongly increased extracellular levels of acetylcholine (ACh) in the dorsal hippocampus [Hartmann, J., Kiewert, C., Duysen, E.G., Lockridge, O., Greig, N.H., Klein, J., 2007.
Positive_regulation (increased) of ACh in hippocampus associated with hippocampus
12) Confidence 0.27 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 18023504 Disease Relevance 0 Pain Relevance 0.09
Decreased ACh levels caused by infusion of HC-3 or tetrodotoxin (TTX) were accompanied by increased levels of free choline.
Positive_regulation (caused) of ACh associated with tetrodotoxin
13) Confidence 0.27 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 18023504 Disease Relevance 0 Pain Relevance 0.17
In contrast, infusion of a selective inhibitor of BChE (bambuterol) caused up to fivefold elevation of ACh levels in AChE-/- mice, but was without effect in AChE+/+ animals.
Positive_regulation (elevation) of ACh
14) Confidence 0.23 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17212694 Disease Relevance 0.25 Pain Relevance 0.13
That is, at equieffective doses, a 60-min prior i.p. injection of ET-1 blocked the behavioral response to a subsequent i.p. injection of ET-1 or PpQ, but not of ACh, whereas a 60-min prior injection of ACh or of PpQ had no effect on a subsequent i.p. injection of ACh, PpQ or ET-1.
Positive_regulation (injection) of ACh
15) Confidence 0.23 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8764328 Disease Relevance 0.14 Pain Relevance 0.12
Cultured muscle cells were electrically blocked with tetrodotoxin (TTX), or co-treated with ACh in order to isolate ACh receptor activation.
Positive_regulation (activation) of ACh in muscle cells associated with tetrodotoxin
16) Confidence 0.16 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9125468 Disease Relevance 0 Pain Relevance 0.37
We present a series of experiments examining whether prothrombin and/or PN1 gene expression, as well as thrombin activity, are regulated in muscle cultures by acetylcholine (ACh) receptor activation.
Spec (whether) Positive_regulation (activation) of ACh in muscle
17) Confidence 0.14 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9125468 Disease Relevance 0 Pain Relevance 0.26
Extracellular ACh levels in the hippocampus were 60-fold elevated in AChE-/- mice compared with wild-type (AChE+/+) animals.
Positive_regulation (elevated) of ACh in hippocampus associated with hippocampus
18) Confidence 0.14 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17212694 Disease Relevance 0.34 Pain Relevance 0.14
Infusion of a selective AChE inhibitor (BW284c51) caused a dose-dependent, up to 16-fold increase of extracellular ACh levels in AChE+/+ mice but did not change ACh levels in AChE-/- mice.
Positive_regulation (increase) of ACh
19) Confidence 0.14 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17212694 Disease Relevance 0.28 Pain Relevance 0.14
We conclude that lack of AChE causes dramatically increased levels of extracellular ACh in the brain.
Positive_regulation (increased) of ACh in brain
20) Confidence 0.14 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17212694 Disease Relevance 0.21 Pain Relevance 0.11

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