INT39846

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Context Info
Confidence 0.75
First Reported 1985
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 0.61
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Olr1746)
Anatomy Link Frequency
CPA 1
spinal cord 1
Olr1746 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 18 100.00 Very High Very High Very High
antidepressant 15 99.96 Very High Very High Very High
Oxycodone 8 99.62 Very High Very High Very High
agonist 46 99.50 Very High Very High Very High
Spinal cord 5 97.82 Very High Very High Very High
MU agonist 2 97.32 Very High Very High Very High
Hippocampus 48 96.16 Very High Very High Very High
lidocaine 4 95.80 Very High Very High Very High
Nucleus accumbens 12 94.00 High High
noradrenaline 1 93.56 High High
Disease Link Frequency Relevance Heat
Adenoma 1 98.92 Very High Very High Very High
Nociception 1 95.28 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

4 89.08 High High
Pain 21 65.76 Quite High
Vomiting 4 47.60 Quite Low
Disease 7 46.36 Quite Low
Appetite Loss 5 44.08 Quite Low
Rheumatoid Arthritis 3 35.04 Quite Low
Urological Neuroanatomy 12 25.84 Quite Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In situ hybridization results indicate that TRPC4 or 5 mRNA is highly expressed in the LS and PFC.
Gene_expression (expressed) of or 5
1) Confidence 0.75 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.19
To determine if TRPC4 or 5 protein expression is developmentally regulated, we examined expression at different stages of development in the HIP.
Gene_expression (expression) of or 5 associated with hippocampus
2) Confidence 0.75 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.13
In contrast, agonists at other 5-HT receptors or 5-HT receptor antagonists do not produce antidepressant-like behavioral effects.
Neg (not) Gene_expression (produce) of or 5 associated with antidepressant, antagonist and agonist
3) Confidence 0.65 Published 1994 Journal Neurosci Biobehav Rev Section Abstract Doc Link 8170624 Disease Relevance 0 Pain Relevance 0.74
Normal adrenal tissue expressed both 5–HT4(a) and 5–HT4(b) and rarely 5–HT4(d) splice variants while adrenocortical aldosterone producing adenomas increased their expression of 5–HT4(d) and no longer expressed 5–HT4(a) or 5–HT4(b) receptor splice variants [22].
Neg (no) Gene_expression (expressed) of or 5 associated with adenoma
4) Confidence 0.58 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.10 Pain Relevance 0
Using a conditioned place aversion (CPA) test, we found that intra-vBNST injection of timolol, a beta-adrenoceptor antagonist, dose-dependently attenuated the acetic acid-induced CPA without reducing nociceptive behaviors.
Gene_expression (injection) of vBNST in CPA associated with nociception and antagonist
5) Confidence 0.13 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 18793681 Disease Relevance 0.16 Pain Relevance 0.47
The NFAS-5 had lower levels of missing data than the NFAS-4 which may indicate higher responder acceptability.
Gene_expression (had) of NFAS-5
6) Confidence 0.13 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2276196 Disease Relevance 0 Pain Relevance 0
The NFAS-5 produced the largest correlations between domains and between domains and total scores, which was significant (p < 0.05) for 15 items and four domains.
Gene_expression (produced) of NFAS-5
7) Confidence 0.13 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2276196 Disease Relevance 0 Pain Relevance 0
All items had more missing data for the NFAS-4 than NFAS-5 (Table 2).
Gene_expression (than) of NFAS-5
8) Confidence 0.11 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2276196 Disease Relevance 0.11 Pain Relevance 0.11
Repeated administration of oxycodone modifies the gene expression of several drug metabolising enzymes in the hepatic tissue of male Sprague-Dawley rats, including glutathione S-transferase A-5 (rGSTA5) and CYP3A2.
Gene_expression (expression) of A-5 associated with oxycodone
9) Confidence 0.05 Published 2010 Journal J. Pharm. Pharmacol. Section Title Doc Link 20487198 Disease Relevance 0 Pain Relevance 0.56
Repeated administration of oxycodone modifies the gene expression of several drug metabolising enzymes in the hepatic tissue of male Sprague-Dawley rats, including glutathione S-transferase A-5 (rGSTA5) and CYP3A2.
Gene_expression (transferase) of A-5 associated with oxycodone
10) Confidence 0.05 Published 2010 Journal J. Pharm. Pharmacol. Section Title Doc Link 20487198 Disease Relevance 0 Pain Relevance 0.56
Renal pelvic instillation of lidocaine (5 micrograms/ml) did not affect the renal functional or electrophysiological responses to increases RVP but abolished the increase in ipsi ARNA, the decrease in contra ERNA, and the increases in contra V and UNaV produced by increasing ureteral pressure (UP) or retrograde ureteropelvic perfusion with 0.9 M NaCl [chemoreceptor (CR) stimulation].
Gene_expression (produced) of UNaV associated with lidocaine
11) Confidence 0.02 Published 1985 Journal Am. J. Physiol. Section Abstract Doc Link 4051004 Disease Relevance 0 Pain Relevance 0.20
Chronic T6 spinal cord section abolished the increase in ipsi ARNA, the decrease in contra ERNA, and the increases in contra V and UNaV produced by renal MR (increases RVP, increases UP) and CR stimulation.
Gene_expression (produced) of UNaV in spinal cord associated with spinal cord
12) Confidence 0.02 Published 1985 Journal Am. J. Physiol. Section Abstract Doc Link 4051004 Disease Relevance 0 Pain Relevance 0.25

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