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Context Info
Confidence 0.47
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.44
Pain Relevance 2.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Neurod1) nucleocytoplasmic transport (Neurod1) nucleus (Neurod1)
DNA binding (Neurod1) transcription factor binding (Neurod1) cytoplasm (Neurod1)
Anatomy Link Frequency
photoreceptors 1
brain 1
Neurod1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 16 99.98 Very High Very High Very High
gABA 3 99.60 Very High Very High Very High
agonist 5 98.80 Very High Very High Very High
Desipramine 5 97.40 Very High Very High Very High
withdrawal 11 96.96 Very High Very High Very High
tramadol 8 96.76 Very High Very High Very High
antidepressant 5 95.76 Very High Very High Very High
anesthesia 5 95.44 Very High Very High Very High
noradrenaline 6 93.52 High High
opioid receptor 3 90.44 High High
Disease Link Frequency Relevance Heat
Stress 4 99.04 Very High Very High Very High
Blindness 1 92.36 High High
Substance Withdrawal Syndrome 1 92.28 High High
Glaucoma 31 89.60 High High
Depression 1 89.04 High High
Ganglion Cysts 3 87.68 High High
Hypotension 2 79.28 Quite High
Hyperalgesia 1 76.04 Quite High
Sleep Disorders 4 75.00 Quite High
Heart Rate Under Development 1 70.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No significant interaction with vascular beta 2-adrenoceptors was observed.
beta 2 Neg (No) Binding (interaction) of
1) Confidence 0.47 Published 1985 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 4051641 Disease Relevance 0.28 Pain Relevance 0.19
Epiboxidine was about 10-fold less potent than epibatidine and about 17-fold more potent than ABT 418 in inhibiting [3H]nicotine binding to alpha 4 beta 2 nicotinic receptors in rat cerebral cortical membranes.
beta 2 Binding (binding) of associated with nicotine
2) Confidence 0.36 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9063687 Disease Relevance 0 Pain Relevance 0.25
The intravenous general anesthetic etomidate acts by potentiating GABA(A) receptors, with selectivity for beta2 and beta3 subunit-containing receptors determined by a single asparagine residue.
beta2 Binding (selectivity) of associated with gaba
3) Confidence 0.36 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 13679430 Disease Relevance 0.20 Pain Relevance 0.43
We assessed the involvement of beta-adrenoreceptors, particularly beta2-receptors in the activity of these drugs.
beta2 Binding (involvement) of
4) Confidence 0.36 Published 2007 Journal Behav Pharmacol Section Abstract Doc Link 17912046 Disease Relevance 0.34 Pain Relevance 0.86
This study sought to establish whether (+/-)-epibatidine, like (-)-nicotine, also displays a wide diversity of behavioral responses that are known to be elicited by nAChR activation or whether it demonstrates subtype selectivity for its interactions with nAChRs.(+/-)-Epibatidine displaced [3H](-)-cytisine binding to the alpha 4 beta 2 nAChR subtype in rat brain membranes with high affinity (Ki, 43 pM).
beta 2 Binding (binding) of in brain associated with nicotine
5) Confidence 0.35 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7965777 Disease Relevance 0 Pain Relevance 0.16
Overexpression of ATOH7 and interaction with the neuroD gene in chickens increases the amount of RGC and photoreceptors [18].
neuroD Binding (interaction) of in photoreceptors
6) Confidence 0.18 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2883590 Disease Relevance 0.27 Pain Relevance 0
The delta receptor associates with G(i alpha1), G(i alpha3), G(o alpha), G(beta1) and G(beta2) subtypes.
beta2 Binding (associates) of
7) Confidence 0.18 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9190886 Disease Relevance 0.11 Pain Relevance 0.37
We also show that the upregulation of epibatidine binding sites attributable to chronic nicotine, an effect associated with beta2-containing receptors, is probably not related to the mechanisms underlying withdrawal.
beta2 Binding (associated) of associated with nicotine and withdrawal
8) Confidence 0.13 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15537871 Disease Relevance 0.23 Pain Relevance 0.62

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