INT39867

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Context Info
Confidence 0.35
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 7.65
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col2a1) extracellular region (Col2a1) proteinaceous extracellular matrix (Col2a1)
cytoplasm (Col2a1)
Anatomy Link Frequency
chondrocytes 3
cleavage 2
CII 2
articular cartilage 1
body 1
Col2a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 214 100.00 Very High Very High Very High
rheumatoid arthritis 101 99.12 Very High Very High Very High
Arthritis 277 99.08 Very High Very High Very High
Inflammation 99 98.98 Very High Very High Very High
Inflammatory response 17 96.04 Very High Very High Very High
Acupuncture 57 95.20 Very High Very High Very High
cytokine 62 92.16 High High
cINOD 2 84.08 Quite High
aspirin 1 78.88 Quite High
metalloproteinase 19 76.04 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 136 100.00 Very High Very High Very High
Immunization 38 100.00 Very High Very High Very High
Mycobacterial Infection 2 99.96 Very High Very High Very High
Sprains And Strains 9 99.92 Very High Very High Very High
Body Weight 14 99.52 Very High Very High Very High
Rheumatoid Arthritis 104 99.12 Very High Very High Very High
Arthritis 296 99.08 Very High Very High Very High
INFLAMMATION 118 98.98 Very High Very High Very High
Disease 58 94.88 High High
Knee Osteoarthritis 86 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A battery of drugs which are commonly used as therapeutic agents for arthritis was tested for effects on the inflammatory and immunological responses of DBA/1J mice, after immunization with type II collagen.
type II collagen Binding (immunization) of associated with inflammation, immunization and arthritis
1) Confidence 0.35 Published 1985 Journal Immunopharmacology Section Abstract Doc Link 4055344 Disease Relevance 0.62 Pain Relevance 0.31
This model can be elicited in susceptible strains by immunization with type II collagen (CII), the major protein of articular cartilage.
type II collagen Binding (immunization) of in articular cartilage associated with immunization and sprains and strains
2) Confidence 0.11 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 1.04 Pain Relevance 0.25
Collagen-induced arthritis (CIA) is generated in genetically susceptible mouse or rat strains by immunization with type II collagen (CII) dissolved in complete Freund's adjuvant (CFA).
type II collagen Binding (immunization) of in CII associated with immunization, sprains and strains and arthritis
3) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 1.12 Pain Relevance 0.42
CIA is an animal model of human rheumatoid arthritis that can be induced in susceptible mice by immunization with type II collagen (CII) (20).
type II collagen Binding (immunization) of in CII associated with immunization, rheumatoid arthritis and arthritis
4) Confidence 0.10 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1810363 Disease Relevance 1.65 Pain Relevance 0.98
Thus, an increase in these cleavage products can be detected in vivo by immunoassays with antibodies that recognize cleavage epitopes called COL2-3/4Clongmono (also known as C2C) and specific for type II collagen [14], and collagenase cleavage epitopes called COL2-3/4Cshort or C1,2C, which detect cleavages of both type II and I collagens [15], have been generated and are markedly elevated in experimental OA [27].
COL2 Binding (recognize) of in cleavage associated with osteoarthritis
5) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212578 Disease Relevance 0.28 Pain Relevance 0.17
Correlations between the arthritis score and body weight at the time of primary immunization with Type II Collagen was carried out using the Spearman Rank Correlation Analysis in Winstat™ add-in for Excel™.
Type II Collagen Binding (immunization) of in body associated with body weight, immunization and arthritis
6) Confidence 0.06 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2907316 Disease Relevance 0.56 Pain Relevance 0.18
Thus, an increase in these cleavage products can be detected in vivo by immunoassays with antibodies that recognize cleavage epitopes called COL2-3/4Clongmono (also known as C2C) and specific for type II collagen [14], and collagenase cleavage epitopes called COL2-3/4Cshort or C1,2C, which detect cleavages of both type II and I collagens [15], have been generated and are markedly elevated in experimental OA [27].
COL2 Binding (recognize) of in cleavage associated with osteoarthritis
7) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212578 Disease Relevance 0.41 Pain Relevance 0.21
g bovine type II collagen emulsified in Freund's complete adjuvant, containing paraffin oil, and lyophilized Mycobacterium tuberculosis H37 Ra (Difco Becton Dickinson, Cowley, Oxford, UK).
type II collagen Binding (lyophilized) of associated with mycobacterial infection and rheumatoid arthritis
8) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246249 Disease Relevance 1.39 Pain Relevance 0.41
To investigate the effect of HNE-binding to Col II on chondrocyte function, we first documented changes in cell morphology and viability by phase-contrast microscopy and MTT assay, respectively.
Col II Binding (binding) of in chondrocyte
9) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.07 Pain Relevance 0.04
Taken together, these findings suggest that interactions between chondrocytes and HNE-modified Col II may contribute to the production of inflammatory and catabolic mediators known to be involved in OA.


Col II Binding (interactions) of in chondrocytes associated with inflammation and osteoarthritis
10) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.33 Pain Relevance 0.17
The main purpose of this study was to investigate interactions between human OA chondrocytes and HNE-modified Col II.
Col II Binding (interactions) of in chondrocytes associated with osteoarthritis
11) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.17 Pain Relevance 0.05

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