INT3987

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Context Info
Confidence 0.70
First Reported 1976
Last Reported 2010
Negated 9
Speculated 3
Reported most in Abstract
Documents 316
Total Number 320
Disease Relevance 283.20
Pain Relevance 40.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
skin 12
mast cell 11
blood 10
lung 8
eosinophil 6
IGHE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1696 100.00 Very High Very High Very High
metalloproteinase 24 100.00 Very High Very High Very High
Analgesic 8 99.96 Very High Very High Very High
Chronic pancreatitis 33 99.90 Very High Very High Very High
aspirin 139 99.88 Very High Very High Very High
cytokine 1869 99.84 Very High Very High Very High
Fibrositis 10 99.84 Very High Very High Very High
carbamazepine 5 99.84 Very High Very High Very High
headache 86 99.56 Very High Very High Very High
Pain 106 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1750 100.00 Very High Very High Very High
Eosinophilia 587 100.00 Very High Very High Very High
Myocardial Infarction 80 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 12 100.00 Very High Very High Very High
Generalized Epilepsy 8 100.00 Very High Very High Very High
Hypersensitivity 1737 99.98 Very High Very High Very High
Disease 2134 99.96 Very High Very High Very High
Infection 1462 99.96 Very High Very High Very High
Eczema 516 99.96 Very High Very High Very High
Pneumonia 178 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Laboratory data were normal, except for serum IgE, which was elevated (2072 IU/ml).
Positive_regulation (elevated) of IgE
1) Confidence 0.70 Published 2006 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 16972620 Disease Relevance 0.97 Pain Relevance 0.16
Serological examination showed no elevation in the number of eosinophils or in IgE level, but histological examination revealed well-developed lymph follicles with increased numbers of eosinophils.
Neg (no) Positive_regulation (elevation) of IgE in lymph
2) Confidence 0.70 Published 2002 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 12102425 Disease Relevance 0.32 Pain Relevance 0.14
Blood hypereosinophilia was borderline and total IgE was clearly increased.
Positive_regulation (increased) of IgE in Blood
3) Confidence 0.70 Published 2002 Journal Presse Med Section Body Doc Link 12355992 Disease Relevance 0.18 Pain Relevance 0
He also had marked hypereosinophilia (51.5%), elevated serum IgE levels (34040 IU/ml), and generalized enlargement of the superficial cervical lymph nodes, containing eosinophilic granulomas.
Positive_regulation (elevated) of IgE in superficial cervical lymph nodes associated with eosinophilic granuloma
4) Confidence 0.70 Published 1998 Journal J. Gastroenterol. Section Abstract Doc Link 9497232 Disease Relevance 1.47 Pain Relevance 0.14
In both episodes, headache and fever were followed by lymphadenopathy, with increased serum IgE level.
Positive_regulation (increased) of IgE associated with lymphadenopathy, headache and fever
5) Confidence 0.70 Published 2008 Journal Rinsho Shinkeigaku Section Abstract Doc Link 18453162 Disease Relevance 0.99 Pain Relevance 0.10
By ELISA, all of them were sero-positive to Gnathostoma doloresi antigen and had elevated IgE levels.
Positive_regulation (elevated) of IgE
6) Confidence 0.70 Published 2003 Journal Parasitol. Int. Section Abstract Doc Link 12798924 Disease Relevance 0.91 Pain Relevance 0.25
Hyper IgE recurrent infection syndrome (HIES, or Job's syndrome) is a primary immunodeficiency characterized by recurrent skin and lung infections, eczema, elevated serum immunoglobulin E (IgE) levels, and various connective tissue and skeletal system abnormalities including characteristic facies, scoliosis, joint hyperextensibility, retained primary dentition, craniosynostosis, osteopenia, and pathologic fractures.
Positive_regulation (elevated) of IgE in lung associated with syndrome, spontaneous fractures, osteoporosis, eczema, infection, scoliosis, facies, craniosynostosis, congenital anomalies and immunodeficiency
7) Confidence 0.70 Published 2007 Journal Clin. Immunol. Section Abstract Doc Link 17098478 Disease Relevance 1.84 Pain Relevance 0.05
Radioallergosorbent test results were positive to several foods, and the total serum immunoglobulin E (IgE) level was elevated.
Positive_regulation (elevated) of IgE
8) Confidence 0.69 Published 2002 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 11960068 Disease Relevance 0.99 Pain Relevance 0.08
Adherence to a gluten-free diet caused a normalization in the endomysial antibody titer; however, the total serum IgE level continued to increase, and the total eosinophil count remained elevated.
Positive_regulation (increase) of IgE in eosinophil
9) Confidence 0.69 Published 2002 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 11960068 Disease Relevance 1.01 Pain Relevance 0.09
IgE is activated by the cross bridging of protein allergens resulting in the release of histamine and increased synthesis of inflammatory mediators such as prostaglandins, causing bronchoconstriction and plasma exudate in allergic asthmatic patients (Turner & Kinet 1999).
Positive_regulation (activated) of IgE in plasma associated with asthma, inflammatory mediators and hypersensitivity
10) Confidence 0.69 Published 2008 Journal Core Evidence Section Body Doc Link PMC2899803 Disease Relevance 1.10 Pain Relevance 0.15
Neither eosinophilia nor elevated IgE levels were constant findings.
Neg (Neither) Positive_regulation (elevated) of IgE associated with eosinophilia
11) Confidence 0.69 Published 2000 Journal Eur. J. Pediatr. Section Abstract Doc Link 10923230 Disease Relevance 0.80 Pain Relevance 0.08
It is frequently associated with milk hypersensitivity and, less usual, with other foods and increased IgE.
Positive_regulation (increased) of IgE associated with milk hypersensitivity
12) Confidence 0.69 Published 2004 Journal Rev Alerg Mex Section Abstract Doc Link 15794416 Disease Relevance 0.86 Pain Relevance 0.09
RESULTS: Clinical features of IPSF comprise early onset; acute or sudden onset; concomitant sharp pain or cholinergic urticaria over the entire body; lack of autonomic dysfunction other than generalized anhidrosis; elevated serum IgE levels; and marked response to steroid.
Positive_regulation (elevated) of IgE in autonomic
13) Confidence 0.69 Published 2004 Journal Neurology Section Body Doc Link 15505168 Disease Relevance 0.08 Pain Relevance 0
Other complementary data include eosinophilia (16 per 100), increased levels of IgE and specific immunofluorescent antibody titer of 1/6000.
Positive_regulation (increased) of IgE associated with eosinophilia
14) Confidence 0.69 Published 1992 Journal Cir Pediatr Section Abstract Doc Link 1567748 Disease Relevance 0.45 Pain Relevance 0.09
A diagnosis of Churg-Strauss syndrome was made on the basis of the presence of preceding asthma, eosinophilia, increased IgE, and the histological findings of a biopsy taken from the purpura.
Spec (findings) Positive_regulation (increased) of IgE associated with asthma, purpura, syndrome and eosinophilia
15) Confidence 0.69 Published 2001 Journal J. Dermatol. Section Abstract Doc Link 11320709 Disease Relevance 1.19 Pain Relevance 0.09
The IgE level was mildly increased to 397 IU/ml (normal < 250).
Positive_regulation (increased) of IgE
16) Confidence 0.69 Published 2001 Journal Rinsho Shinkeigaku Section Abstract Doc Link 11771161 Disease Relevance 0.49 Pain Relevance 0.16
Besides an elevated IgE level no clinical signs of a true anaphylactic reaction associated with release of mast cell mediators had been observed.
Positive_regulation (elevated) of IgE in mast cell
17) Confidence 0.69 Published 2009 Journal Int J Clin Pharmacol Ther Section Body Doc Link 19281725 Disease Relevance 0.06 Pain Relevance 0
Laboratory examinations yielded a marked eosinophilia and a grossly elevated IgE level in combination with an inflammatory reaction restricted to the subcutaneous tissues.
Positive_regulation (elevated) of IgE associated with inflammation and eosinophilia
18) Confidence 0.69 Published 2000 Journal Int. J. Infect. Dis. Section Abstract Doc Link 10689216 Disease Relevance 0.44 Pain Relevance 0.14
According to our data, 1-month exposure to formaldehyde and phenol during an anatomy dissection course does not induce specific IgE against formaldehyde or phenol.
Neg (not) Positive_regulation (induce) of IgE in anatomy
19) Confidence 0.69 Published 1996 Journal Allergy Section Abstract Doc Link 8947343 Disease Relevance 0.73 Pain Relevance 0.13
Total serum IgE levels were elevated in every patient (except in those with contact dermatitis).
Positive_regulation (elevated) of IgE associated with contact dermatitis
20) Confidence 0.69 Published 2008 Journal J Indian Med Assoc Section Abstract Doc Link 18828339 Disease Relevance 1.03 Pain Relevance 0.05

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