INT39870

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Context Info
Confidence 0.36
First Reported 1985
Last Reported 1985
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.80
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Odc1) lyase activity (Odc1) molecular_function (Tk1)
kinase activity (Tk1) cytoplasm (Tk1)
Anatomy Link Frequency
liver 2
Odc1 (Rattus norvegicus)
Tk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 8 97.94 Very High Very High Very High
Disease Link Frequency Relevance Heat
Liver Failure 6 98.62 Very High Very High Very High
Injury 4 97.56 Very High Very High Very High
Necrosis 2 75.00 Quite High
Coma 2 48.80 Quite Low
Acute Liver Failure 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After massive liver injury with acetaminophen, subcoma doses of hepatic failure toxins (NH+4, dimethyl disulfide [----methanethiol], octanoic acid) depressed liver thymidine kinase (TK) activity by 78%, 85%, and 90%, respectively, and ornithine decarboxylase (ODC) activity by 40%, 83%, and 78%, respectively.
ODC Negative_regulation (depressed) of TK in liver associated with liver failure, paracetamol and injury
1) Confidence 0.36 Published 1985 Journal J. Lab. Clin. Med. Section Abstract Doc Link 4056569 Disease Relevance 0.40 Pain Relevance 0.23
After massive liver injury with acetaminophen, subcoma doses of hepatic failure toxins (NH+4, dimethyl disulfide [----methanethiol], octanoic acid) depressed liver thymidine kinase (TK) activity by 78%, 85%, and 90%, respectively, and ornithine decarboxylase (ODC) activity by 40%, 83%, and 78%, respectively.
ornithine decarboxylase Negative_regulation (depressed) of TK in liver associated with liver failure, paracetamol and injury
2) Confidence 0.36 Published 1985 Journal J. Lab. Clin. Med. Section Abstract Doc Link 4056569 Disease Relevance 0.40 Pain Relevance 0.23

General Comments

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