INT39874

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Context Info
Confidence 0.68
First Reported 1982
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 5.41
Pain Relevance 3.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Reg1)
Anatomy Link Frequency
bile 3
PSP 2
nerve 1
NIT-1 1
vesicles 1
Reg1 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 7 99.80 Very High Very High Very High
Bile 33 99.64 Very High Very High Very High
Chronic pancreatitis 7 99.00 Very High Very High Very High
Enkephalin 8 98.48 Very High Very High Very High
tetrodotoxin 3 97.60 Very High Very High Very High
medulla 2 96.72 Very High Very High Very High
depression 1 96.24 Very High Very High Very High
Inflammation 5 91.20 High High
Inflammatory response 2 90.60 High High
local anesthetic 2 89.52 High High
Disease Link Frequency Relevance Heat
Cirrhosis 2 99.84 Very High Very High Very High
Cv General 3 Under Development 8 99.80 Very High Very High Very High
Stress 2 99.70 Very High Very High Very High
Choledocholithiasis 2 99.16 Very High Very High Very High
Pancreatitis 15 99.00 Very High Very High Very High
Cancer 3 97.84 Very High Very High Very High
Choledochal Cyst 6 97.48 Very High Very High Very High
Depression 1 96.24 Very High Very High Very High
Diabetes Mellitus 154 95.12 Very High Very High Very High
Chronic Renal Failure 3 94.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hypothesis of a presynaptic origin of PTP at this muscarinic synapse was corroborated in the experiments where acetylcholine stores were labelled with [3H] choline and the release of the label was increased during PTP.
Positive_regulation (increased) of PTP in synapse
1) Confidence 0.68 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7094998 Disease Relevance 0.21 Pain Relevance 0.25
up-regulates Reg1 and Reg2 genes in NIT-1 cells.
Positive_regulation (regulates) of Reg1 in NIT-1
2) Confidence 0.40 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.00 Pain Relevance 0.09
RTCs resulted in proportional increases of Ptp and ICP.
Positive_regulation (increases) of Ptp associated with cva
3) Confidence 0.30 Published 1995 Journal Pediatr. Res. Section Abstract Doc Link 8552431 Disease Relevance 0.69 Pain Relevance 0.46
Thus, sodium entry into nerve terminals enables a mechanism which greatly prolongs PTP.
Positive_regulation (prolongs) of PTP in nerve
4) Confidence 0.25 Published 1985 Journal J. Neurosci. Section Abstract Doc Link 4056860 Disease Relevance 0.23 Pain Relevance 0.40
This study provides the first demonstration that PTP exists as a multicatalytic cysteine protease complex that can be activated by endogenous glutathione present in chromaffin granules.
Positive_regulation (activated) of PTP
5) Confidence 0.23 Published 1999 Journal Biochemistry Section Abstract Doc Link 10360939 Disease Relevance 0 Pain Relevance 0.21
Bile in pancreaticobiliary maljunction patients contained both activated trypsin and PSP.
Positive_regulation (activated) of PSP in Bile associated with bile
6) Confidence 0.18 Published 2004 Journal Dig. Dis. Sci. Section Abstract Doc Link 15628732 Disease Relevance 0.20 Pain Relevance 0.51
Evidence for the proenkephalin processing enzyme prohormone thiol protease (PTP) as a multicatalytic cysteine protease complex: activation by glutathione localized to secretory vesicles.
Positive_regulation (activation) of PTP in vesicles associated with enkephalin
7) Confidence 0.15 Published 1999 Journal Biochemistry Section Title Doc Link 10360939 Disease Relevance 0 Pain Relevance 0.30
Furthermore, the serum PSP/reg-protein concentration was also significantly increased in liver cirrhosis, choledocholithiasis, and various cancers of the digestive system, and was extremely high in all patients tested with chronic renal failure.
Positive_regulation (increased) of PSP in PSP associated with chronic renal failure, cirrhosis, cancer and choledocholithiasis
8) Confidence 0.13 Published 1995 Journal J. Gastroenterol. Section Abstract Doc Link 8574338 Disease Relevance 1.09 Pain Relevance 0.18
Whereas only 7 of these patients showed a normal serum PSP/reg-protein concentration and a significantly increased elastase-I concentration, 15 of these patients showed a significantly increased serum PSP/reg-protein concentration and a normal serum elastase-I concentration.
Positive_regulation (increased) of PSP in PSP
9) Confidence 0.13 Published 1995 Journal J. Gastroenterol. Section Abstract Doc Link 8574338 Disease Relevance 1.03 Pain Relevance 0.17
Activated pancreatic enzyme and pancreatic stone protein (PSP/reg) in bile of patients with pancreaticobiliary maljunction/ choledochal cysts.
Positive_regulation (Activated) of PSP in bile associated with bile and choledochal cyst
10) Confidence 0.13 Published 2004 Journal Dig. Dis. Sci. Section Title Doc Link 15628732 Disease Relevance 0.28 Pain Relevance 0.50
Activated pancreatic enzyme and pancreatic stone protein (PSP/reg) in bile of patients with pancreaticobiliary maljunction/ choledochal cysts.
Positive_regulation (Activated) of pancreatic stone protein in bile associated with bile and choledochal cyst
11) Confidence 0.11 Published 2004 Journal Dig. Dis. Sci. Section Title Doc Link 15628732 Disease Relevance 0.28 Pain Relevance 0.50
This is accompanied by induction of degP expression, as a result of the activation of the RpoE (SigmaE) extra-cytoplasmic stress response, and activation of the psp operon.
Positive_regulation (activation) of psp operon associated with stress
12) Confidence 0.01 Published 2006 Journal Biochim. Biophys. Acta Section Abstract Doc Link 16836975 Disease Relevance 0.41 Pain Relevance 0.24

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