INT3988

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Context Info
Confidence 0.68
First Reported 1976
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 98
Total Number 100
Disease Relevance 91.46
Pain Relevance 9.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
mast cells 8
T cell 8
B cells 7
blood 6
skin 6
IGHE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1067 100.00 Very High Very High Very High
cytokine 910 100.00 Very High Very High Very High
Inflammatory mediators 43 100.00 Very High Very High Very High
Morphine 6 100.00 Very High Very High Very High
pruritus 15 99.28 Very High Very High Very High
rheumatoid arthritis 28 97.28 Very High Very High Very High
Pain 28 95.56 Very High Very High Very High
ischemia 3 95.56 Very High Very High Very High
Inflammatory response 45 94.84 High High
beta blocker 39 92.96 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 1133 100.00 Very High Very High Very High
Rhinitis 549 100.00 Very High Very High Very High
Eosinophilia 257 100.00 Very High Very High Very High
Disease 857 99.98 Very High Very High Very High
Infection 338 99.98 Very High Very High Very High
Eczema 184 99.92 Very High Very High Very High
Chronic Sinusitis 537 99.84 Very High Very High Very High
Cancer 221 99.84 Very High Very High Very High
Sicca Syndrome 20 99.84 Very High Very High Very High
Pulmonary Eosinophilia 5 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown experimentally that there are conditions under which alternative mechanisms may induce IgE production independent of IL-4 [44].
Positive_regulation (induce) of Gene_expression (production) of IgE
1) Confidence 0.68 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.37 Pain Relevance 0.08
This increase in IgE production between 0 and six years of age may also reflect an increase in the capacity of the immune system to respond to parasite infections [7,27].
Positive_regulation (increase) of Gene_expression (production) of IgE in immune system associated with infection
2) Confidence 0.68 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.82 Pain Relevance 0.04
An in vivo AHR accompanied by increased IgE production and pulmonary eosinophilia has been demonstrated in the actively sensitized and repeatedly OA-challenged BALB/c strain of mice [20].
Positive_regulation (increased) of Gene_expression (production) of IgE associated with sprains and strains and pulmonary eosinophilia
3) Confidence 0.67 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0.20 Pain Relevance 0
In atopic subjects, total IgE production may increase.
Spec (may) Positive_regulation (increase) of Gene_expression (production) of IgE
4) Confidence 0.64 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2822745 Disease Relevance 1.04 Pain Relevance 0.27
Immune assessment shows elevated IgE levels in spite of deficiency in B cells numbers, panhypogammaglobulinemia, oligoclonal, nonfunctional T cell expansion and excessive Th2 skewing.
Positive_regulation (elevated) of Gene_expression (levels) of IgE in T cell
5) Confidence 0.62 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2837605 Disease Relevance 3.08 Pain Relevance 0.04
Recurrent vaginitis as a result of sexual transmission of IgE antibodies.
Positive_regulation (transmission) of Gene_expression (transmission) of IgE associated with reprotox - general 2
6) Confidence 0.50 Published 1988 Journal Am. J. Obstet. Gynecol. Section Title Doc Link 3394750 Disease Relevance 0.62 Pain Relevance 0.13
Even in Gabonese patients, for whom the increase of IgE in the disease groups was not significant, a higher percentage of patients with clinical disease had higher IgE levels than controls and asymptomatic patients.
Positive_regulation (had) of Gene_expression (levels) of IgE associated with disease
7) Confidence 0.49 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 1.01 Pain Relevance 0
In conclusion, these results showed that total IgE levels increased in infected patients, mainly in UM and SM patients but not in CM patients.
Neg (not) Positive_regulation (increased) of Gene_expression (levels) of IgE associated with malaria and cerebral malaria
8) Confidence 0.49 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.50 Pain Relevance 0.10
Although the median total IgE levels in the Indian NEC groups was higher than that of the Gabonese EC group, suggesting that age could be an important factor in IgE production, the higher IgE levels in the Indian population may also be interpreted as the result of either environmental factors, such as predominance of food allergies, of the genetic background, which may predispose to developing IgE responses [13,27,29-32] or of a co-infection with other parasites, such as helminths affecting the IgE responses in these patients [33,34].
Positive_regulation (factor) of Gene_expression (production) of IgE associated with food hypersensitivity and infection
9) Confidence 0.49 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.49 Pain Relevance 0
Although the median total IgE levels in the Indian NEC groups was higher than that of the Gabonese EC group, suggesting that age could be an important factor in IgE production, the higher IgE levels in the Indian population may also be interpreted as the result of either environmental factors, such as predominance of food allergies, of the genetic background, which may predispose to developing IgE responses [13,27,29-32] or of a co-infection with other parasites, such as helminths affecting the IgE responses in these patients [33,34].
Positive_regulation (factor) of Gene_expression (levels) of IgE associated with food hypersensitivity and infection
10) Confidence 0.49 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.50 Pain Relevance 0
Even in Gabonese patients, for whom the increase of IgE in the disease groups was not significant, a higher percentage of patients with clinical disease had higher IgE levels than controls and asymptomatic patients.
Positive_regulation (higher) of Gene_expression (levels) of IgE associated with disease
11) Confidence 0.49 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 1.01 Pain Relevance 0
With this in mind, solid phases of some selected compounds containing substituted ammonium groups, in particular triethylamine and morphine, were prepared and used to screen sera in an attempt to increase the frequency of detection of IgE antibodies complementary to tertiary and/or quaternary ammonium groups.
Positive_regulation (increase) of Gene_expression (detection) of IgE associated with morphine
12) Confidence 0.49 Published 1990 Journal Mol. Immunol. Section Abstract Doc Link 2233754 Disease Relevance 0.17 Pain Relevance 0.16
In Western blots, sera from 92% of EE/PE patients demonstrated IgG and IgE antibodies to a component of ES antigen with a molecular weight of approximately 68 kD (Ac68), as did all sera from cases infected with human hookworms.
Positive_regulation (demonstrated) of Gene_expression (demonstrated) of IgE associated with enteritis and eosinophilia
13) Confidence 0.49 Published 1994 Journal Am. J. Trop. Med. Hyg. Section Abstract Doc Link 8304575 Disease Relevance 1.74 Pain Relevance 0.05
He also had marked hypereosinophilia (51.5%), elevated serum IgE levels (34040 IU/ml), and generalized enlargement of the superficial cervical lymph nodes, containing eosinophilic granulomas.
Positive_regulation (elevated) of Gene_expression (levels) of IgE in superficial cervical lymph nodes associated with eosinophilic granuloma
14) Confidence 0.47 Published 1998 Journal J. Gastroenterol. Section Abstract Doc Link 9497232 Disease Relevance 1.48 Pain Relevance 0.14
Methods for increasing the detection of NMBD-reactive IgE antibodies are outlined.
Positive_regulation (increasing) of Gene_expression (detection) of IgE
15) Confidence 0.46 Published 1993 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 8368586 Disease Relevance 0.07 Pain Relevance 0.23
Pholcodine is one such drug, which in a recent pilot study was shown to induce a remarkable increase in serum IgE levels in two IgE-sensitized individuals.
Positive_regulation (increase) of Gene_expression (levels) of IgE
16) Confidence 0.46 Published 2007 Journal Allergy Section Abstract Doc Link 17983379 Disease Relevance 0.25 Pain Relevance 0
Other complementary data include eosinophilia (16 per 100), increased levels of IgE and specific immunofluorescent antibody titer of 1/6000.
Positive_regulation (increased) of Gene_expression (levels) of IgE associated with eosinophilia
17) Confidence 0.46 Published 1992 Journal Cir Pediatr Section Abstract Doc Link 1567748 Disease Relevance 0.45 Pain Relevance 0.09
RESULTS: Clinical features of IPSF comprise early onset; acute or sudden onset; concomitant sharp pain or cholinergic urticaria over the entire body; lack of autonomic dysfunction other than generalized anhidrosis; elevated serum IgE levels; and marked response to steroid.
Positive_regulation (elevated) of Gene_expression (levels) of IgE in autonomic
18) Confidence 0.46 Published 2004 Journal Neurology Section Body Doc Link 15505168 Disease Relevance 0.08 Pain Relevance 0
Total serum IgE levels were elevated in every patient (except in those with contact dermatitis).
Positive_regulation (elevated) of Gene_expression (levels) of IgE associated with contact dermatitis
19) Confidence 0.46 Published 2008 Journal J Indian Med Assoc Section Abstract Doc Link 18828339 Disease Relevance 1.03 Pain Relevance 0.05
The hyperimmunoglobulin E (HIE) (Job's) syndrome often has it onset in childhood and is characterized by markedly elevated serum IgE levels, chronic dermatitis and recurrent pyogenic infections.
Positive_regulation (elevated) of Gene_expression (levels) of IgE associated with syndrome, eczema and infection
20) Confidence 0.46 Published 2004 Journal Tumori Section Abstract Doc Link 15143986 Disease Relevance 1.13 Pain Relevance 0.07

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