INT39884

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.56
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 11.93
Pain Relevance 3.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp) nucleus (Mbp) cytoplasm (Mbp)
Anatomy Link Frequency
white matter 3
striatum 2
corpus callosum 2
spinal cord 1
caudate putamen 1
Mbp (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 109 99.54 Very High Very High Very High
Hippocampus 108 98.80 Very High Very High Very High
Neuropathic pain 104 97.32 Very High Very High Very High
allodynia 40 96.84 Very High Very High Very High
Peripheral nerve injury 8 96.44 Very High Very High Very High
Spinal cord 105 95.24 Very High Very High Very High
Inflammation 103 93.08 High High
dorsal root ganglion 15 92.32 High High
anesthesia 18 86.92 High High
imagery 15 85.84 High High
Disease Link Frequency Relevance Heat
Hypoxia 30 99.78 Very High Very High Very High
Demyelinating Disease 158 99.54 Very High Very High Very High
Injury 63 98.32 Very High Very High Very High
Multiple Sclerosis 404 97.80 Very High Very High Very High
Neuropathic Pain 158 97.32 Very High Very High Very High
Nervous System Injury 57 96.00 Very High Very High Very High
Coronary Heart Disease 2 95.04 Very High Very High Very High
Pressure Volume 2 Under Development 8 93.84 High High
INFLAMMATION 107 93.08 High High
Disease 87 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PACAP (5 x 10(-8) mol/kg) injections produced a long-lasting potent decline of MBP, rCBF and cerebral pO2.
Negative_regulation (decline) of MBP
1) Confidence 0.56 Published 2004 Journal Regul. Pept. Section Abstract Doc Link 15518894 Disease Relevance 0.32 Pain Relevance 0.15
PACAP (5 x 10(-10)-5 x 10(-9) mol/kg) injections transiently decreased MBP, and cerebral pO2.
Negative_regulation (decreased) of MBP
2) Confidence 0.56 Published 2004 Journal Regul. Pept. Section Abstract Doc Link 15518894 Disease Relevance 0.34 Pain Relevance 0.16
Among the myelin proteins investigated, expression levels of MOG, MBP and MAG, except that of CNPase, were significantly attenuated in 6 week-old Olig1?
Negative_regulation (attenuated) of MBP
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 0.42 Pain Relevance 0.11
Although it is now unclear how white matter damage impairs the social interaction in CPZ-treated mice, some clues may be drawn from the following findings of the present study: first, HAL did not improve the performance of CPZ-treated mice in social interaction test (Figure 3A) whereas it mitigated the CPZ-induced MBP decrease in PFC (Figure 5); second, the myelin sheath loss in CPZ?
Negative_regulation (decrease) of MBP in white matter
4) Confidence 0.36 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0.06 Pain Relevance 0.03
In the HAL experiment (Figures 7A,D), this decrease in the amount of MBP was not affected by HAL as the CPZ?
Negative_regulation (decrease) of MBP
5) Confidence 0.36 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0 Pain Relevance 0.03
Significant decreases in the amount of MBP in CP were seen in all experiments (Figure 7).
Negative_regulation (decreases) of MBP
6) Confidence 0.36 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0 Pain Relevance 0.03
The CPZ-treated mice did not show deficit in social interaction until 4th week after CPZ-exposure when the loss of myelin sheath and MBP became evident (Xu et al., 2009), suggesting normal performance in social interaction relies on intact white matter.
Negative_regulation (loss) of MBP in white matter
7) Confidence 0.36 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0.08 Pain Relevance 0
ligand preserved myelin basic protein (MBP) immunoreactivity in the corpus callosum of mice with EAE.
Negative_regulation (preserved) of MBP in corpus callosum associated with multiple sclerosis
8) Confidence 0.35 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.96 Pain Relevance 0
Expression levels of MBP were decreased in the cortex, striatum axonal bundles and corpus callosum of A?
Negative_regulation (levels) of MBP in striatum
9) Confidence 0.32 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.11 Pain Relevance 0
days showed myelin sheath loss and lower myelin basic protein in PFC, caudate putamen, and hippocampus.
Negative_regulation (loss) of myelin basic protein in caudate putamen associated with hippocampus
10) Confidence 0.32 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Abstract Doc Link PMC2842101 Disease Relevance 0.20 Pain Relevance 0.13
Although the continuing presence of at least some BrdU+ cells in the CC at 56 days offered the possibility that the damage to myelin occurring at this time point might be reversible, analysis at 6 months demonstrated a striking loss of cells and of MBP.
Negative_regulation (loss) of MBP
11) Confidence 0.32 Published 2008 Journal J Biol Section Body Doc Link PMC2397490 Disease Relevance 0.11 Pain Relevance 0.03
Immunofluorescence staining with an anti-myelin basic protein (anti-MBP) antibody revealed that there was also markedly decreased MBP staining in animals treated with 5-FU examined 56 days after treatment (data not shown).
Negative_regulation (decreased) of MBP
12) Confidence 0.31 Published 2008 Journal J Biol Section Body Doc Link PMC2397490 Disease Relevance 0.23 Pain Relevance 0.03
Furthermore, LPA1 receptor-mediated demyelination was evidenced by down-regulation of myelin-associated proteins, such as MBP and peripheral myelin protein 22 kDa (PMP22), in the dorsal root after LPA injection or peripheral nerve injury.
Negative_regulation (regulation) of MBP in dorsal root associated with demyelination, nervous system injury and peripheral nerve injury
13) Confidence 0.29 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 1.63 Pain Relevance 0.99
Using an in situ hybridization technique that gives high resolution and is very sensitive, we examined myelin basic protein and proteolipid protein gene expression three and twenty-four hours after a H-I insult.
Spec (examined) Negative_regulation (examined) of myelin basic protein
14) Confidence 0.28 Published 2001 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 11255033 Disease Relevance 0.88 Pain Relevance 0.08
Twenty-four hours following H--I, myelin basic protein and proteolipid protein transcripts were markedly reduced in striatum, external capsule, fornix, and corpus callosum in the injured side.
Negative_regulation (reduced) of myelin basic protein in corpus callosum
15) Confidence 0.28 Published 2001 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 11255033 Disease Relevance 0.85 Pain Relevance 0.07
Three hours after lesioning (ligation+70 min hypoxic exposure) myelin basic protein gene transcripts were visibly reduced in the ipsilateral white matter tracts.
Negative_regulation (reduced) of myelin basic protein in white matter associated with hypoxia
16) Confidence 0.25 Published 2001 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 11255033 Disease Relevance 0.80 Pain Relevance 0.06
The number of MAC3+ cells, CD3+ cells, APP and dMBP-positive deposits, SMI-positive axons, and the level of demyelination in LFB staining were quantified on three lumbal spinal cord sections in at least three mice per group using an Olympus BX51 microscope (Olympus, Hamburg, Germany) equipped with a digital camera (SIS Color View) attached to a computer with software for image analysis (AnalySIS; Soft Imaging System, http://www.soft-imaging.net).
Negative_regulation (number) of dMBP in spinal cord associated with demyelination, imagery and spinal cord
17) Confidence 0.13 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.25 Pain Relevance 0.30
We obtained evidence that LPA1 receptor activation mediates down-regulation of myelin proteins, such as peripheral myelin protein PMP22, myelin basic protein MBP, and myelin protein zero MP0, in in vivo injury models and ex vivo culture models [73,74].
Negative_regulation (regulation) of myelin basic protein MBP associated with injury
18) Confidence 0.13 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 1.27 Pain Relevance 0.66
Expression levels of MBP were decreased in the cortex, striatum axonal bundles and corpus callosum of A?
Negative_regulation (levels) of MBP in cortex
19) Confidence 0.11 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.11 Pain Relevance 0
days showed myelin sheath loss and lower myelin basic protein in PFC, caudate putamen, and hippocampus.
Negative_regulation (loss) of myelin basic protein in hippocampus associated with hippocampus
20) Confidence 0.11 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Abstract Doc Link PMC2842101 Disease Relevance 0.20 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox