INT39900

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Context Info
Confidence 0.50
First Reported 1981
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 36
Total Number 37
Disease Relevance 20.35
Pain Relevance 5.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha)
cytoplasm (Ldha)
Anatomy Link Frequency
hepatocytes 8
liver 6
visceral 4
CAR 4
ovary 4
Ldha (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 76 100.00 Very High Very High Very High
Paracetamol 64 100.00 Very High Very High Very High
Glutamate 27 100.00 Very High Very High Very High
ischemia 71 98.80 Very High Very High Very High
Inflammation 116 97.88 Very High Very High Very High
analgesia 8 97.60 Very High Very High Very High
epidural 6 97.20 Very High Very High Very High
halothane 2 96.72 Very High Very High Very High
adenocard 12 96.24 Very High Very High Very High
Pain 37 95.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 158 99.96 Very High Very High Very High
Hypoalbuminemia 2 99.96 Very High Very High Very High
Hepatotoxicity 45 99.90 Very High Very High Very High
Death 58 99.72 Very High Very High Very High
Stress 37 99.66 Very High Very High Very High
Metastasis 9 99.62 Very High Very High Very High
Cancer 8 99.56 Very High Very High Very High
Myalgia 5 98.88 Very High Very High Very High
Cv Unclassified Under Development 51 98.80 Very High Very High Very High
Injury 194 98.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The acetaminophen-induced GSH depletion and ensuing lactate dehydrogenase (LDH) leakage were quite modest and delayed in onset, in contrast to that caused by iodoacetamide (IAA) and by diethylmaleate (DEM), 2 well-known depletors of GSH.
Positive_regulation (acetaminophen-induced) of Gene_expression (depletion) of LDH associated with paracetamol
1) Confidence 0.50 Published 1985 Journal Toxicology Section Abstract Doc Link 4060164 Disease Relevance 0 Pain Relevance 0.42
The acetaminophen-induced GSH depletion and ensuing lactate dehydrogenase (LDH) leakage were quite modest and delayed in onset, in contrast to that caused by iodoacetamide (IAA) and by diethylmaleate (DEM), 2 well-known depletors of GSH.
Positive_regulation (acetaminophen-induced) of Gene_expression (depletion) of lactate dehydrogenase associated with paracetamol
2) Confidence 0.50 Published 1985 Journal Toxicology Section Abstract Doc Link 4060164 Disease Relevance 0 Pain Relevance 0.42
The electrophoretic separation pattern of serum lactate dehydrogenase isoenzymes in normal and injury groups showed that CCl4 injection resulted in a significant increase in all serum levels of LDH isoenzymes.
Positive_regulation (increase) of Gene_expression (isoenzymes) of LDH associated with injury
3) Confidence 0.41 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.19 Pain Relevance 0.05
Our study found that the increased ratios of S/L, LDH and CK, and the decreased levels of TP in groups M, C and group K compared to group S in the survival rats.
Positive_regulation (increased) of Gene_expression (ratios) of LDH
4) Confidence 0.39 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2564972 Disease Relevance 1.24 Pain Relevance 0.25
Doxorubicin significantly increased oxidative stress as evidenced by increased levels of LDH and TBARS and decreased antioxidant enzymes levels.
Positive_regulation (increased) of Gene_expression (levels) of LDH associated with stress
5) Confidence 0.37 Published 2010 Journal Indian Journal of Pharmacology Section Abstract Doc Link PMC2885640 Disease Relevance 0.54 Pain Relevance 0.25
Doxorubicin significantly increased oxidative stress as evidenced by increased levels of LDH and TBARS and decreased antioxidant enzymes levels.
Positive_regulation (levels) of Gene_expression (levels) of LDH associated with stress
6) Confidence 0.37 Published 2010 Journal Indian Journal of Pharmacology Section Abstract Doc Link PMC2885640 Disease Relevance 0.54 Pain Relevance 0.25
Takayama et al. [28] have observed that coenzyme Q10 lowers the increased level of serum LDH in rats subjected to hepatic ischemia-reperfusion
Positive_regulation (increased) of Gene_expression (level) of LDH associated with ischemia
7) Confidence 0.36 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.19 Pain Relevance 0.05
A significant (P < 0.01) increase in the activity of LDH in serum was observed in the ischemic (MCAO) group rats, as compared to the sham group; whereas, aqueous extract of Embelia ribes treatment significantly (P < 0.01) resulted in decreased serum LDH levels when compared with the ischemic (MCAO) group rats.
Positive_regulation (resulted) of Gene_expression (levels) of LDH associated with middle cerebral artery infarction
8) Confidence 0.34 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792627 Disease Relevance 0.55 Pain Relevance 0.04
Surgery under general anaesthesia was followed by increased levels of bilirubin, LDH, CPK, glucose and cortisol, whereas AP and ALAT were unaffected by surgery.
Positive_regulation (levels) of Gene_expression (levels) of LDH
9) Confidence 0.32 Published 1981 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 7324821 Disease Relevance 0 Pain Relevance 0.45
The levels of SOD, ACP, LDH, SDH, NOS, NO and GSH were significantly elevated by taurine administration in aged rats, the levels of AST and ALT were significantly decreased, but the levels of AKP and MDA had no changes.
Positive_regulation (elevated) of Gene_expression (levels) of LDH
10) Confidence 0.31 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0 Pain Relevance 0
Increased levels of interstitial potassium but normal levels of muscle IL-6 and LDH in patients with trapezius myalgia.
Positive_regulation (Increased) of Gene_expression (levels) of LDH in trapezius associated with myalgia
11) Confidence 0.30 Published 2005 Journal Pain Section Title Doc Link 16297553 Disease Relevance 0.54 Pain Relevance 0.27
There was a statistically significant (P<0.05) increase in the GLDH (S3-NP, S2, S3 groups) and AST, LDH (S3 group) activity, a decrease in URE (S2, S3 groups) and decrease in TP (S3-NP, S2, S3 groups) compared to the corresponding control group.
Positive_regulation (increase) of Gene_expression (group) of LDH associated with glutamate
12) Confidence 0.28 Published 2001 Journal Hum Exp Toxicol Section Abstract Doc Link 11926611 Disease Relevance 0 Pain Relevance 0.44
Itraconazole induced statistically significant LDH leakage at 0.01?
Positive_regulation (induced) of Gene_expression (leakage) of LDH
13) Confidence 0.25 Published 2009 Journal Journal of Toxicology Section Body Doc Link PMC2809023 Disease Relevance 0.18 Pain Relevance 0
-tachykinin) with significantly increased expression in the ipsilateral and contralateral LDH of CAR-P3 rats as compared to those in CONT animals (Table 1).
Positive_regulation (increased) of Gene_expression (expression) of LDH in CAR associated with spinal dorsal horn
14) Confidence 0.24 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 0 Pain Relevance 0.12
This study has revealed that CAR injection of a hindpaw in rat pups during neonatal sensitive period leads to abnormal expression levels of multiple genes in the LDH of adult animals, both at the basal and CFA-induced inflammation states.
Positive_regulation (leads) of Gene_expression (expression) of LDH in CAR associated with inflammation and spinal dorsal horn
15) Confidence 0.22 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 0.40 Pain Relevance 0.39
Surgery under general anaesthesia was followed by increased levels of bilirubin, LDH, CPK, glucose and cortisol, whereas AP and ALAT were unaffected by surgery.
Positive_regulation (increased) of Gene_expression (levels) of LDH
16) Confidence 0.22 Published 1981 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 7324821 Disease Relevance 0 Pain Relevance 0.45
mg/kg ISO subcutaneously) showed significant increase (P < .001) in serum levels of CK-MB, LDH, GOT, ALK-P and uric acid compared to Group I (vehicle-treated rats injected with normal saline 2?
Positive_regulation (levels) of Gene_expression (levels) of LDH
17) Confidence 0.20 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952329 Disease Relevance 0.18 Pain Relevance 0
Rats administered with ISO showed significant increase in the serum levels of glutamate oxaloacetate transaminase, alkaline phosphotase, creatinine kinase isoenzymes, lactate dehydrogenase, and uric acid, while F1 and F2 treatment showed significant reduction in the same.
Positive_regulation (increase) of Gene_expression (levels) of lactate dehydrogenase associated with glutamate
18) Confidence 0.20 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2952329 Disease Relevance 0 Pain Relevance 0.05
A significant increase in the levels of ASAT, ALAT, ALP, total bilirubin, LDH (P < 0.001) and a significant reduction in the levels of TGL, total proteins, and albumin (P < 0.001) were observed in hepatocytes exposed to CCl4 when compared to normal rats.
Positive_regulation (increase) of Gene_expression (levels) of LDH in hepatocytes
19) Confidence 0.19 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2907024 Disease Relevance 0 Pain Relevance 0
Increased serum levels of CK-MB, LDH, ALK-P, GOT and uric acid are the diagnostic indicators of ISO-induced MI.
Positive_regulation (Increased) of Gene_expression (levels) of LDH associated with myocardial infarction
20) Confidence 0.18 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952329 Disease Relevance 0.65 Pain Relevance 0

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