INT39901

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Context Info
Confidence 0.53
First Reported 1985
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha)
cytoplasm (Ldha)
Ldha (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 5 99.74 Very High Very High Very High
lidocaine 4 84.92 Quite High
Disease Link Frequency Relevance Heat
Injury 1 39.92 Quite Low
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LDH loss was equally suppressed at pH 6.4 only during Ca(2+)-depletion, whereas pH 6.4 was markedly less effective when perfused only during Ca(2+)-repletion.
Negative_regulation (suppressed) of Negative_regulation (loss) of LDH
1) Confidence 0.53 Published 1996 Journal Kidney Int. Section Abstract Doc Link 8648904 Disease Relevance 0 Pain Relevance 0.16
The acetaminophen-induced GSH depletion and ensuing lactate dehydrogenase (LDH) leakage were quite modest and delayed in onset, in contrast to that caused by iodoacetamide (IAA) and by diethylmaleate (DEM), 2 well-known depletors of GSH.
Negative_regulation (delayed) of Negative_regulation (depletion) of lactate dehydrogenase associated with paracetamol
2) Confidence 0.43 Published 1985 Journal Toxicology Section Abstract Doc Link 4060164 Disease Relevance 0 Pain Relevance 0.42
Reduction of the pH of the perfusion fluid to 6.8 significantly inhibited LDH loss, and at pH 6.4 this leakage was almost completely suppressed.
Negative_regulation (inhibited) of Negative_regulation (loss) of LDH
3) Confidence 0.39 Published 1996 Journal Kidney Int. Section Abstract Doc Link 8648904 Disease Relevance 0 Pain Relevance 0.17

General Comments

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