INT39905

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Context Info
Confidence 0.16
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.10
Pain Relevance 5.77

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nucleoplasm (ALKBH2) oxidoreductase activity (ALKBH2) nucleus (ALKBH2)
Anatomy Link Frequency
blood 4
dorsal 1
ALKBH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Oxycodone 92 99.96 Very High Very High Very High
Dismenorea 1 98.02 Very High Very High Very High
Raphe 2 85.56 High High
drug abuse 24 75.00 Quite High
Opioid 12 53.16 Quite High
alcohol 4 51.32 Quite High
tolerance 4 25.00 Low Low
Pain 2 25.00 Low Low
nociceptor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pre-term Labor 1 99.80 Very High Very High Very High
Reprotox - General 1 1 98.02 Very High Very High Very High
Nociception 5 89.52 High High
Drug Dependence 24 75.00 Quite High
Asthma 1 67.68 Quite High
Toxicity 12 61.12 Quite High
Death 16 48.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Assessment of blood levels determined by specific assay methodology (primarily gas chromatography-mass spectrometry) in these cases provided the following mean postmortem concentrations of OXC: multiple-drug-induced deaths, OxyContin identified, 0.93 microg/mL (N = 167); multiple-drug-induced deaths, OxyContin not identified, 0.73 microg/mL (N = 579); single (OXC)-drug-induced deaths, OxyContin identified, 1.55 microg/mL (N = 12); and single (OXC)-drug-induced deaths, OxyContin not identified, 1.70 microg/mL (N = 15).
Positive_regulation (multiple-drug-induced) of OxyContin in blood associated with oxycodone
1) Confidence 0.16 Published 2004 Journal J Anal Toxicol Section Abstract Doc Link 15516322 Disease Relevance 0.39 Pain Relevance 1.34
Assessment of blood levels determined by specific assay methodology (primarily gas chromatography-mass spectrometry) in these cases provided the following mean postmortem concentrations of OXC: multiple-drug-induced deaths, OxyContin identified, 0.93 microg/mL (N = 167); multiple-drug-induced deaths, OxyContin not identified, 0.73 microg/mL (N = 579); single (OXC)-drug-induced deaths, OxyContin identified, 1.55 microg/mL (N = 12); and single (OXC)-drug-induced deaths, OxyContin not identified, 1.70 microg/mL (N = 15).
Positive_regulation (multiple-drug-induced) of OxyContin in blood associated with oxycodone
2) Confidence 0.16 Published 2004 Journal J Anal Toxicol Section Abstract Doc Link 15516322 Disease Relevance 0.39 Pain Relevance 1.42
Assessment of blood levels determined by specific assay methodology (primarily gas chromatography-mass spectrometry) in these cases provided the following mean postmortem concentrations of OXC: multiple-drug-induced deaths, OxyContin identified, 0.93 microg/mL (N = 167); multiple-drug-induced deaths, OxyContin not identified, 0.73 microg/mL (N = 579); single (OXC)-drug-induced deaths, OxyContin identified, 1.55 microg/mL (N = 12); and single (OXC)-drug-induced deaths, OxyContin not identified, 1.70 microg/mL (N = 15).
Positive_regulation (multiple-drug-induced) of OxyContin in blood associated with oxycodone
3) Confidence 0.16 Published 2004 Journal J Anal Toxicol Section Abstract Doc Link 15516322 Disease Relevance 0.38 Pain Relevance 1.39
Assessment of blood levels determined by specific assay methodology (primarily gas chromatography-mass spectrometry) in these cases provided the following mean postmortem concentrations of OXC: multiple-drug-induced deaths, OxyContin identified, 0.93 microg/mL (N = 167); multiple-drug-induced deaths, OxyContin not identified, 0.73 microg/mL (N = 579); single (OXC)-drug-induced deaths, OxyContin identified, 1.55 microg/mL (N = 12); and single (OXC)-drug-induced deaths, OxyContin not identified, 1.70 microg/mL (N = 15).
Positive_regulation (multiple-drug-induced) of OxyContin in blood associated with oxycodone
4) Confidence 0.16 Published 2004 Journal J Anal Toxicol Section Abstract Doc Link 15516322 Disease Relevance 0.44 Pain Relevance 1.44
It appears that these two analogues, particularly dE-TVT, would be interesting for clinical testing both in dysmenorrhea, where increased VP secretion could be of etiological importance, and in premature labor where an increased myometrial concentration of OXY receptors has been demonstrated.
Positive_regulation (increased) of OXY associated with dismenorea and pre-term labor
5) Confidence 0.14 Published 1985 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 4061066 Disease Relevance 0.20 Pain Relevance 0.10
RESULTS: Oxy increased Amin by 46% (delta = 0.48 +/- 0.07 cm2, P = 0.0001) and V6 by 53% (Delta = 9.9 +/- 1.5 mL, P < 1 x 10-7) during the first 30 min.
Positive_regulation (increased) of Oxy
6) Confidence 0.03 Published 2002 Journal Clin. Exp. Allergy Section Body Doc Link 11972600 Disease Relevance 0.07 Pain Relevance 0
A significant increase in oxyHb level was observed in the ventral part of PFC compared with the dorsal part of PFC.
Positive_regulation (increase) of oxyHb in dorsal
7) Confidence 0.01 Published 2010 Journal J. Med. Dent. Sci. Section Abstract Doc Link 20437764 Disease Relevance 0.24 Pain Relevance 0.08

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