INT39908

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Context Info
Confidence 0.69
First Reported 1985
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 16
Total Number 21
Disease Relevance 4.80
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp27b1) oxidoreductase activity (Cyp27b1) aging (Cyp27b1)
cytoplasm (Cyp27b1)
Anatomy Link Frequency
plasma 1
liver 1
Mouse 1
kidney 1
Cyp27b1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 29 100.00 Very High Very High Very High
Pain 6 100.00 Very High Very High Very High
tricyclic antidepressant 2 100.00 Very High Very High Very High
Inflammation 34 95.56 Very High Very High Very High
Kinase C 8 90.68 High High
cytokine 64 85.68 High High
Bile 75 79.88 Quite High
Potency 3 72.96 Quite High
anesthesia 7 71.76 Quite High
agonist 22 65.16 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 13 100.00 Very High Very High Very High
Pain 6 100.00 Very High Very High Very High
Asthma 32 99.14 Very High Very High Very High
Malignant Neoplastic Disease 4 98.76 Very High Very High Very High
Nicotine Addiction 16 98.24 Very High Very High Very High
Ovarian Cancer 4 97.92 Very High Very High Very High
INFLAMMATION 34 95.56 Very High Very High Very High
Toxicity 11 85.56 High High
Cancer 29 81.52 Quite High
Necrosis 4 81.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased Fgf23 suppresses the expression of Cyp27b1 and induces the expression of Cyp24 by activating the ?
Gene_expression (expression) of Cyp27b1
1) Confidence 0.69 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.19 Pain Relevance 0.10
The Fgf23 suppresses the expression of Cyp27b1 and induces the expression of Cyp24 in the kidney (Shimada et al 2004).
Gene_expression (expression) of Cyp27b1 in kidney
2) Confidence 0.53 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.23 Pain Relevance 0.03
The suppression of Cyp27b1 expression and induction of Cyp24 expression by Fgf23 result in decreased levels of active vitamin D in serum.
Gene_expression (expression) of Cyp27b1
3) Confidence 0.53 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.32 Pain Relevance 0.03
In addition, Fgf23 also suppresses the expression of Cyp27b1 (1?
Gene_expression (expression) of Cyp27b1
4) Confidence 0.53 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.73 Pain Relevance 0.03
The production of 20 alpha-OH-progesterone (20 alpha-OH-P) in women with malignant epithelial ovarian tumors was investigated.
Spec (investigated) Gene_expression (production) of alpha-OH-progesterone associated with malignant neoplastic disease and ovarian cancer
5) Confidence 0.42 Published 1985 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 4061067 Disease Relevance 0.57 Pain Relevance 0.07
Immunoblot analysis of microsomal proteins showed that rutaecarpine-treatment increased the protein levels of CYP1A1 and CYP1A2 in the liver, whereas hepatic level of CYP3A-immunoreacted protein was not affected by rutaecarpine.
Gene_expression (levels) of CYP1A1 in liver
6) Confidence 0.26 Published 2001 Journal Life Sci. Section Abstract Doc Link 11787945 Disease Relevance 0.12 Pain Relevance 0.06
The co-segregation of elevated basal Cyp1a1 and CYP1a2 gene expression levels in animals selected for susceptibility to acetaminophen-induced hepatotoxicity suggested a common heritable basis for regulation of basal expression of both of these CYP1A isoforms.
Gene_expression (expression) of Cyp1a1 associated with paracetamol and hepatotoxicity
7) Confidence 0.22 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.17 Pain Relevance 0.39
The co-segregation of elevated basal Cyp1a1 and CYP1a2 gene expression levels in animals selected for susceptibility to acetaminophen-induced hepatotoxicity suggested a common heritable basis for regulation of basal expression of both of these CYP1A isoforms.
Gene_expression (expression) of CYP1A associated with paracetamol and hepatotoxicity
8) Confidence 0.22 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.17 Pain Relevance 0.39
Increased basal expression of hepatic Cyp1a1 and Cyp1a2 genes in inbred mice selected for susceptibility to acetaminophen-induced hepatotoxicity.
Gene_expression (expression) of Cyp1a1 associated with paracetamol and hepatotoxicity
9) Confidence 0.22 Published 1997 Journal Pharmacogenetics Section Title Doc Link 9295056 Disease Relevance 0.19 Pain Relevance 0.43
This was supported by the correlated expression of both CYP1A mRNAs within individual mice (r = 0.644, p < 0.02).
Gene_expression (expression) of CYP1A
10) Confidence 0.19 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.17 Pain Relevance 0.30
To analyze expression of SEAP and Cyp1a1 in various organs, we exposed mice to polluted air for 3 hr, as described above.
Spec (analyze) Gene_expression (expression) of Cyp1a1
11) Confidence 0.11 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.25 Pain Relevance 0.03
Figure 5D shows that expression of SEAP and Cyp1a1 in some of the organs decreased after exposure to polluted air, but the result was not consistent with other experiments using distinct pairs of mice (data not shown).
Gene_expression (expression) of Cyp1a1
12) Confidence 0.09 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.28 Pain Relevance 0.03
The mouse MT-CYP1A1 is an extrinsic membrane protein, which exhibited high FDX1 plus FDXR-mediated N-demethylation of a number of tricyclic antidepressants, pain killers, anti-psychotics, and narcotics that are poor substrates for microsomal CYP1A1.
Gene_expression (exhibited) of CYP1A1 associated with pain and tricyclic antidepressant
13) Confidence 0.08 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16899466 Disease Relevance 0.10 Pain Relevance 0.31
The mouse MT-CYP1A1 is an extrinsic membrane protein, which exhibited high FDX1 plus FDXR-mediated N-demethylation of a number of tricyclic antidepressants, pain killers, anti-psychotics, and narcotics that are poor substrates for microsomal CYP1A1.
Gene_expression (exhibited) of CYP1A1 associated with pain and tricyclic antidepressant
14) Confidence 0.08 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16899466 Disease Relevance 0.10 Pain Relevance 0.31
Mouse lines lacking the P450s CYP1A1, CYP1A2, CYP1B1 and CYP2E1, microsomal epoxide hydrolase (mEH), NADPH:quinone oxidoreductase and the glutathione S-transferase P1 have no deleterious phenotypes, indicating that these enzymes are not required for mammalian development and physiological homeostasis.
Neg (lacking) Gene_expression (lacking) of CYP1A1 in Mouse
15) Confidence 0.03 Published 2001 Journal Toxicol. Lett. Section Abstract Doc Link 11323178 Disease Relevance 0.30 Pain Relevance 0.06
Immunoblot analyses showed that methanol extract increased the levels of CYP1A1, CYP1A2, CYP2B-, and GSTYb-immunoreactive proteins.
Gene_expression (levels) of CYP1A1
16) Confidence 0.03 Published 2002 Journal Life Sci. Section Abstract Doc Link 12106592 Disease Relevance 0.11 Pain Relevance 0.06
However, studies with CERK deficient (Cerk-/-) mice have shown that another route for production of C1P must exist, at least in mammals [2,3].
Gene_expression (production) of C1P
17) Confidence 0.01 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.14 Pain Relevance 0
CERK is the only enzyme known to produce ceramide-1-phosphate (C1P) [1].
Gene_expression (produce) of C1P
18) Confidence 0.01 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.09 Pain Relevance 0
Ovalbumin-induced plasma interleukin-4 levels are reduced in ceramide kinase-deficient DO11.10 RAG1-/- mice

Ceramide kinase (CERK) produces the bioactive lipid ceramide-1-phosphate (C1P) and is a key regulator of ceramide and dihydroceramide levels.

Gene_expression (produces) of C1P in plasma
19) Confidence 0.01 Published 2010 Journal Lipids Health Dis Section Title Doc Link PMC2817648 Disease Relevance 0.26 Pain Relevance 0.05
Readouts in DO11.10 were taken after 2 to 4 h whereas analysis in the asthma model took place after 48 h; compensatory C1P synthesis (by unknown mechanisms, cf ref. [2]) might be limiting only for short period of times.
Gene_expression (synthesis) of C1P associated with asthma
20) Confidence 0.01 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.17 Pain Relevance 0.12

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