INT39919

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Context Info
Confidence 0.36
First Reported 1985
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 2.91
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MLN) cell-cell signaling (MLN)
Anatomy Link Frequency
plasma 2
follicles 1
fat 1
B-cell 1
pituitary 1
MLN (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 1 100.00 Very High Very High Very High
Somatostatin 36 99.42 Very High Very High Very High
antagonist 4 98.56 Very High Very High Very High
cytokine 46 98.18 Very High Very High Very High
Potency 1 96.64 Very High Very High Very High
Inflammation 23 85.60 High High
agonist 6 83.88 Quite High
Paracetamol 1 79.76 Quite High
tetrodotoxin 2 63.36 Quite High
behavioral therapy 1 55.68 Quite High
Disease Link Frequency Relevance Heat
Constipation 13 99.36 Very High Very High Very High
Gastric Motility Disorder 10 98.78 Very High Very High Very High
Infection 218 98.74 Very High Very High Very High
Pancreatic Fistula 8 97.24 Very High Very High Very High
INFLAMMATION 23 85.60 High High
Death 25 81.36 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 96 79.36 Quite High
Acromegaly 2 71.84 Quite High
Hypoglycemia 75 69.48 Quite High
Pituitary Cancer 1 68.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies have shown that motilin receptor is expressed in the enteric neurons of the colon [10,13] and plasma motilin concentration is reduced in adults with chronic constipation [14].
Negative_regulation (reduced) of plasma motilin in plasma associated with constipation
1) Confidence 0.36 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2529327 Disease Relevance 0.39 Pain Relevance 0.07
Motilin and ghrelin are the only hormones known to decrease in the postprandial period [64].
Negative_regulation (decrease) of Motilin
2) Confidence 0.28 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925306 Disease Relevance 0.13 Pain Relevance 0.04
Itoh et al. [36] found that the effect of motilin on phase III activity in dogs was blocked by a 5-hydroxytryptamine-3 (5-HT3) antagonist.
Negative_regulation (blocked) of motilin associated with antagonist
3) Confidence 0.28 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925306 Disease Relevance 0 Pain Relevance 0.11
All reviewed RCTs not only agree that somatostatin does not have any influence on occurrence of pancreatic fistula, but Shan et al. [53] also found increased rates of delayed gastric emptying after prophylactic somatostatin administration and provided decreased plasma motilin levels as a possible mechanism [see Additional file 2] [52,62].
Negative_regulation (decreased) of motilin in plasma associated with somatostatin, gastric motility disorder and pancreatic fistula
4) Confidence 0.15 Published 2009 Journal Trials Section Body Doc Link PMC2726965 Disease Relevance 0.28 Pain Relevance 0.31
Thus, trafficking to intestinal mucosa could transiently decrease the B-cell numbers in MLN before D14p.i. but this loss could be balanced by homeostatic mechanisms thereafter.


Negative_regulation (decrease) of MLN in B-cell
5) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.31 Pain Relevance 0
The number of follicles and the size of GC were decreased in MLN on D14p.i. whereas the sizes of both follicles and GC were increased from D21 p.i..
Negative_regulation (decreased) of MLN in follicles
6) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.15 Pain Relevance 0
HAART did not prevent the decrease in GC size in MLN, observed at D14p.i., but cured the increase in GC and other changes observed at D28p.i..
Negative_regulation (decrease) of MLN
7) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.33 Pain Relevance 0.10
Postprandial GIP secretion and plasma motilin levels were unaffected by addition of guar gum to the fat meal. 5 and 10 g guar gum/l solutions in water possessed buffering capacities between pH 2.75 and 5.5.
Neg (unaffected) Negative_regulation (unaffected) of plasma motilin in fat
8) Confidence 0.07 Published 1985 Journal Br. J. Nutr. Section Abstract Doc Link 4063284 Disease Relevance 0 Pain Relevance 0.08
Octreotide has effects similar to those of somatostatin but with greater potency and longer duration of action; these effects include inhibition of pituitary release of growth hormone and thyrotropin, inhibition of glucagon or insulin release, and inhibition of the secretion of various gastrointestinal tract hormones (e.g. serotonin, pepsin, gastrin, secretin, motilin, vasoactive intestinal peptide and pancreatic peptides) [9,10].
Negative_regulation (inhibition) of motilin in pituitary associated with somatostatin, serotonin and potency
9) Confidence 0.06 Published 2005 Journal Crit Care Section Body Doc Link PMC1414034 Disease Relevance 0.73 Pain Relevance 0.26
The most affected cytokine in acute T. cruzi infection is IL-2, an important growth factor for T lymphocytes that is suppressed in the thymus, MLN, and spleen, but not in SCLN.
Neg (not) Negative_regulation (suppressed) of MLN in T lymphocytes associated with infection and cytokine
10) Confidence 0.02 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 0.59 Pain Relevance 0.09

General Comments

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