INT39945

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Context Info
Confidence 0.32
First Reported 1985
Last Reported 2011
Negated 4
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 14.95
Pain Relevance 3.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Dlat) transferase activity, transferring acyl groups (Dlat)
Anatomy Link Frequency
plasma 1
brain 1
Dlat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 39 100.00 Very High Very High Very High
cINOD 3 100.00 Very High Very High Very High
Glutamate receptor 5 99.12 Very High Very High Very High
antidepressant 29 99.08 Very High Very High Very High
Chronic pancreatitis 2 98.36 Very High Very High Very High
Acupuncture 45 98.00 Very High Very High Very High
ischemia 242 97.00 Very High Very High Very High
pruritus 28 94.08 High High
visual analogue scale 48 93.08 High High
antagonist 34 92.24 High High
Disease Link Frequency Relevance Heat
Biliary Liver Cirrhosis 108 100.00 Very High Very High Very High
INFLAMMATION 1 100.00 Very High Very High Very High
Fatigue 207 99.98 Very High Very High Very High
Dermatomyositis 4 99.98 Very High Very High Very High
Primary Sclerosing Cholangitis 84 99.84 Very High Very High Very High
Inflammatory Bowel Disease 3 99.80 Very High Very High Very High
Autoimmune Disease 1 99.52 Very High Very High Very High
Diabetes Mellitus 204 99.18 Very High Very High Very High
Aging 8 99.02 Very High Very High Very High
Pancreatitis 2 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: Piroxicam-beta-cyclodextrin (PBC) is the first nonsteroidal anti-inflammatory drug (NSAID), in which the active substance is complexed with the cyclic oligosaccharide cyclodextrin, which acts as an artificial receptor.
PBC Binding (complexed) of associated with inflammation and cinod
1) Confidence 0.32 Published 2002 Journal Bratisl Lek Listy Section Abstract Doc Link 12696775 Disease Relevance 0.17 Pain Relevance 0.57
Thus, we propose that E2 directly binds to and allosterically inhibits GlyRs.


E2 Binding (binds) of
2) Confidence 0.31 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0 Pain Relevance 0.05
The association of PBC and ulcerative colitis may prove to be valid.
PBC Binding (association) of associated with inflammatory bowel disease and biliary liver cirrhosis
3) Confidence 0.30 Published 1985 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 4067230 Disease Relevance 0.72 Pain Relevance 0.17
Thus, it is unlikely that E2 exerts its inhibition on IGly through intracellular signaling pathways.
E2 Neg (inhibition) Binding (inhibition) of
4) Confidence 0.24 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0 Pain Relevance 0.09
Although PBC is often associated with other autoimmune diseases, there have been no reports of PBC complicated by PM and PH.
PBC Binding (associated) of associated with biliary liver cirrhosis, autoimmune disease, hypertension and polymyositis
5) Confidence 0.23 Published 2008 Journal Intern. Med. Section Abstract Doc Link 18379158 Disease Relevance 1.48 Pain Relevance 0.08
Therefore, we evaluated the potential neuroprotective action of the natural estrogen E2 and two synthetic estrogenic compounds that do not bind ER-?
E2 Neg (not) Binding (bind) of
6) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799530 Disease Relevance 0.60 Pain Relevance 0.35
We were interested to know whether E2 and PGN share a common binding site on GlyRs.
E2 Binding (binding) of
7) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0 Pain Relevance 0.06
After recording a control period in the cocktail solution, E2 at 10 ?
E2 Binding (recording) of
8) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0 Pain Relevance 0.18
In this study, however, several lines of evidence suggest that E2 inhibited IGly through a direct interaction with plasma membrane GlyRs.
E2 Binding (interaction) of in plasma
9) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0.18 Pain Relevance 0.18
Thus, (1) natural and synthetic estrogens are neuroprotective when administered after ischemia, (2) these neuroprotective properties are retained even after long-term hormone deprivation in aging females, and 3) synthetic estrogens that do not bind classical ERs are as neuroprotective as E2.
E2 Neg (not) Binding (bind) of associated with aging and ischemia
10) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799530 Disease Relevance 0.57 Pain Relevance 0.16
Oral E2 treatment was given at a dosage of 2 mg kg?
E2 Binding (dosage) of
11) Confidence 0.11 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193542 Disease Relevance 0 Pain Relevance 0.07
Both ERs bind E2 with high affinity and specificity [10].
E2 Binding (bind) of
12) Confidence 0.08 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0 Pain Relevance 0
The actions of E2 and P are primarily mediated via binding to specific intracellular receptors in the target cells.
E2 Binding (binding) of
13) Confidence 0.07 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0 Pain Relevance 0
recruitment by E2 was very effective.
E2 Binding (recruitment) of
14) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.12 Pain Relevance 0.06
It has been predominantly thought that E2 neuroprotection in the brain is mediated principally by the “classical” nuclear ER-mediated genomic signaling pathway, which involves E2 interaction with nuclear ER and regulation of transcription of various genes that mediate neuroprotection.
E2 Binding (interaction) of in brain
15) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 1.05 Pain Relevance 0.37
E2 and P Concentrations in RIA

Table 3 summarized the serum hormone levels in the three groups during implantation period in rat model.

E2 Binding (summarized) of
16) Confidence 0.05 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2957198 Disease Relevance 0 Pain Relevance 0.17
With regards to resistance training behavior, our study revealed no significant associations with intention or PBC with behavior.
PBC Neg (no) Binding (associations) of
17) Confidence 0.05 Published 2008 Journal Int J Behav Nutr Phys Act Section Body Doc Link PMC2633303 Disease Relevance 0.36 Pain Relevance 0
The expression of VEGF mRNA was also markedly elevated with treatment with E2.
E2 Binding (treatment) of
18) Confidence 0.04 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.05 Pain Relevance 0
DM associated with PBC is unusual and cases of monozygotic twins with both conditions are very rare.
PBC Binding (associated) of associated with biliary liver cirrhosis and dermatomyositis
19) Confidence 0.04 Published 2000 Journal Ryumachi Section Abstract Doc Link 11210774 Disease Relevance 1.47 Pain Relevance 0.08
Ab DAT/e2 to the DA transporter binds to the second extracellular domain [42], and was obtained from A.
e2 Binding (binds) of associated with dopamine
20) Confidence 0.04 Published 2006 Journal J Mol Signal Section Body Doc Link PMC1769494 Disease Relevance 0 Pain Relevance 0.05

General Comments

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