INT39948

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Context Info
Confidence 0.42
First Reported 1985
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 45
Total Number 46
Disease Relevance 58.05
Pain Relevance 4.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FLNA) extracellular region (FLNA) plasma membrane (FLNA)
nucleus (FLNA) transcription factor binding (FLNA) cytoplasm (FLNA)
Anatomy Link Frequency
renal artery 5
plasma 2
endothelial cell 2
basilar artery 2
carotid artery 2
FLNA (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 41 100.00 Very High Very High Very High
mu opioid receptor 24 100.00 Very High Very High Very High
cva 66 98.68 Very High Very High Very High
abdominal pain 14 98.08 Very High Very High Very High
imagery 63 97.68 Very High Very High Very High
Inflammation 188 97.64 Very High Very High Very High
tolerance 4 97.44 Very High Very High Very High
Inflammatory response 2 96.16 Very High Very High Very High
opioid receptor 2 93.36 High High
rheumatoid arthritis 190 92.48 High High
Disease Link Frequency Relevance Heat
Fibromuscular Dyplasia 1790 100.00 Very High Very High Very High
Pathologic Constriction 454 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 409 100.00 Very High Very High Very High
Cardiovascular Disease 372 100.00 Very High Very High Very High
Metabolic Syndrome 161 100.00 Very High Very High Very High
Stroke 109 100.00 Very High Very High Very High
Syndrome 98 100.00 Very High Very High Very High
Headache 59 100.00 Very High Very High Very High
Hyperemia 52 100.00 Very High Very High Very High
Artery Disease 24 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report the case of a patient with FMD who required emergent surgery because of rupture of an iliac artery dissection, and review 9 previously reported cases of iliac artery dissection associated with FMD.
FMD Binding (associated) of in iliac artery associated with fibromuscular dyplasia and rupture
1) Confidence 0.42 Published 2004 Journal J. Vasc. Surg. Section Abstract Doc Link 15557923 Disease Relevance 1.26 Pain Relevance 0.10
In multivariate analysis, adjusted for age, gender, IHD and body mass index, no association between FMD and the combined endpoint was found (p=0.99).
FMD Neg (no) Binding (association) of in body
2) Confidence 0.41 Published 2009 Journal Scand. J. Clin. Lab. Invest. Section Body Doc Link 19347749 Disease Relevance 0.06 Pain Relevance 0
CONCLUSION: FMD is associated with IHD, but has no independent prognostic effect in patients with chest pain.


FMD Binding (associated) of in chest
3) Confidence 0.41 Published 2009 Journal Scand. J. Clin. Lab. Invest. Section Body Doc Link 19347749 Disease Relevance 0.06 Pain Relevance 0
Renal artery FMD has been tentatively associated with environmental factors and it is likely that there is a genetic predisposition.
FMD Binding (associated) of in Renal artery associated with fibromuscular dyplasia and genetic predisposition to disease
4) Confidence 0.39 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1899482 Disease Relevance 3.09 Pain Relevance 0.36
Because of the strong association between MetS, CVD, and diabetes, there is urgent need for strategies to prevent the emerging global epidemic.
CVD Binding (association) of associated with diabetes mellitus, cardiovascular disease and metabolic syndrome
5) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483433 Disease Relevance 1.55 Pain Relevance 0.05
There is an exceptional need for health care practitioners to recognize the importance of MetS and CVD among the South Asian migrant community, especially given the populationÂ’s rapid growth.
CVD Neg (exceptional) Binding (recognize) of associated with cardiovascular disease and metabolic syndrome
6) Confidence 0.35 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2742703 Disease Relevance 0.57 Pain Relevance 0
Carotid fibromuscular dysplasia (FMD-C), a stenosing angiopathy, is frequently associated with pulsatile tinnitus.
FMD Binding (associated) of associated with tinnitus, fibromuscular dyplasia and vascular disease
7) Confidence 0.35 Published 1985 Journal J Otolaryngol Section Abstract Doc Link 4068124 Disease Relevance 0.81 Pain Relevance 0.09
An explanation for the fact that we did not find an impairment in FMD following methionine loading could be that we used a lower dose of methionine (50 mg of methionine per kilogram of body weight) than most other studies do (100 mg of methionine per kilogram of body weight).
FMD Neg (impairment) Binding (impairment) of in body associated with body weight
8) Confidence 0.32 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0.24 Pain Relevance 0
In addition, a methionine-loading test increases plasma homocysteine concentrations drastically and can completely abolish FMD [56].
FMD Binding (abolish) of in plasma
9) Confidence 0.32 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0 Pain Relevance 0
In addition, FMD index was assessed 1 month after completion of EECP therapy.
FMD Binding (index) of
10) Confidence 0.32 Published 2008 Journal Heart Lung Circ Section Body Doc Link 18706862 Disease Relevance 0.08 Pain Relevance 0
Ten cases (5 male and 5 female patients), including the present case, with dissection of iliac arteries associated with FMD have been reported.
FMD Binding (associated) of in iliac associated with fibromuscular dyplasia
11) Confidence 0.31 Published 2004 Journal J. Vasc. Surg. Section Abstract Doc Link 15557923 Disease Relevance 1.47 Pain Relevance 0.25
FMD is associated with endothelial function in coronary arteries of patients [19,20].
FMD Binding (associated) of
12) Confidence 0.31 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0.54 Pain Relevance 0
FMD is associated with endothelial function in coronary arteries of patients [17,18].
FMD Binding (associated) of
13) Confidence 0.31 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488898 Disease Relevance 0.42 Pain Relevance 0
Management of renal artery FMD
FMD Binding (Management) of in renal artery associated with fibromuscular dyplasia
14) Confidence 0.30 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1899482 Disease Relevance 2.83 Pain Relevance 0.07
Management of symptomatic carotid artery FMD
FMD Binding (Management) of in carotid artery associated with fibromuscular dyplasia
15) Confidence 0.30 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1899482 Disease Relevance 1.47 Pain Relevance 0.04
Renal artery stenosis due to FMD may be associated with all stages of hypertension, but it is most commonly detected in patients with stage 2–3 hypertension, or abrupt onset or resistant hypertension, since these are the individuals who undergo the most comprehensive etiological examinations.
FMD Binding (associated) of in Renal artery associated with fibromuscular dyplasia, renal artery obstruction and hypertension
16) Confidence 0.30 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1899482 Disease Relevance 1.99 Pain Relevance 0.06
Management of symptomatic carotid artery FMD
FMD Binding (symptomatic) of in carotid artery associated with fibromuscular dyplasia
17) Confidence 0.30 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1899482 Disease Relevance 1.46 Pain Relevance 0.04
Management of cases with renovascular hypertension includes antihypertensive therapy, percutaneous angioplasty of severe stenoses, and reconstructive surgery in cases with complex FMD that extends to segmental arteries.
FMD Binding (extends) of associated with fibromuscular dyplasia, pathologic constriction and hypertension
18) Confidence 0.30 Published 2007 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1899482 Disease Relevance 1.62 Pain Relevance 0.08
The management of hypertension associated with renal artery FMD involves revascularization and/or antihypertensive medication.
FMD Binding (associated) of in renal artery associated with fibromuscular dyplasia and hypertension
19) Confidence 0.30 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1899482 Disease Relevance 2.72 Pain Relevance 0.07
Among the 60 stenoses for which both radiological and histological assessments were available (Table 1), all 38 multifocal stenoses were associated with medial FMD, whereas focal and tubular stenoses were not specifically associated with histological type.
FMD Binding (associated) of in medial associated with fibromuscular dyplasia and pathologic constriction
20) Confidence 0.30 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1899482 Disease Relevance 1.53 Pain Relevance 0

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