INT39972

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Context Info
Confidence 0.65
First Reported 1985
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.17
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CPA1) extracellular space (CPA1) extracellular region (CPA1)
Anatomy Link Frequency
CPA 6
brush 1
CPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 1 97.48 Very High Very High Very High
halothane 16 90.56 High High
Pain 2 86.96 High High
adenocard 5 81.04 Quite High
Hyperesthesia 1 31.44 Quite Low
Glutamate 15 5.00 Very Low Very Low Very Low
methotrexate 12 5.00 Very Low Very Low Very Low
Paracetamol 12 5.00 Very Low Very Low Very Low
Osteoarthritis 9 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 54 99.86 Very High Very High Very High
Cancer 177 99.56 Very High Very High Very High
Colon Cancer 48 98.82 Very High Very High Very High
Contracture 26 98.80 Very High Very High Very High
Severe Combined Immunodeficiency 9 97.88 Very High Very High Very High
Malignant Hyperthermia 36 97.72 Very High Very High Very High
Apoptosis 15 54.00 Quite High
Suicidal Behaviour 21 50.00 Quite Low
Muscle Disease 2 41.12 Quite Low
Disease 2 39.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This presystemic metabolism in the gastrointestinal tract is based on luminally secreted enzymes (I) including pepsins, trypsin, chymotrypsin, elastase and carboxypeptidase A/B, on brush border membrane bound enzymes (II) including various carboxypeptidases and aminopeptidases and on cytosolic enzymes (III).
Gene_expression (based) of carboxypeptidase A in brush
1) Confidence 0.65 Published 2007 Journal Curr. Drug Metab. Section Abstract Doc Link 17584022 Disease Relevance 0 Pain Relevance 0.14
Radiolabelled CPA was biosynthetically produced by cultures of Penicillium griseofulvum and was administered to rats either intraperitoneally (ip) or intragastrically (ig).
Gene_expression (produced) of CPA in CPA
2) Confidence 0.59 Published 1985 Journal Food Chem. Toxicol. Section Abstract Doc Link 4076936 Disease Relevance 0 Pain Relevance 0
mm3 sc tumors from 9L glioma cells transduced with CYP2B6 and NADHP450 reductase with CPA (140?
Gene_expression (transduced) of CPA in CPA associated with cancer and glioma
3) Confidence 0.15 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 0.85 Pain Relevance 0
Transduction of HT29 and T47D human colon carcinoma cells with CYP2B6 using a retroviral vector (MetXia-P450) sensitized these cells to CPA,
Gene_expression (sensitized) of CPA in CPA associated with colon cancer
4) Confidence 0.13 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 0.77 Pain Relevance 0
3.95), the more lipophilic intermediate CPA metabolites (primarily
Gene_expression (metabolites) of CPA in CPA
5) Confidence 0.13 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 0.33 Pain Relevance 0
[41] suggesting that they represent a suitable model for investigating the effects of CPA on the IL-1?
Gene_expression (effects) of CPA in CPA
6) Confidence 0.09 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1820791 Disease Relevance 0 Pain Relevance 0
CPA Cyclopiazonic acid
Gene_expression (acid) of CPA in CPA
7) Confidence 0.07 Published 2005 Journal BMC Anesthesiol Section Body Doc Link PMC1175794 Disease Relevance 1.21 Pain Relevance 0.12

General Comments

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