INT39986

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Context Info
Confidence 0.45
First Reported 1985
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 10.39
Pain Relevance 3.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Agtr2) plasma membrane (Agtr2) transcription factor binding (Agtr2)
signal transducer activity (Agtr2)
Anatomy Link Frequency
liver 1
colon 1
tail 1
MNCs 1
fibroblasts 1
Agtr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 7 99.98 Very High Very High Very High
antagonist 68 99.96 Very High Very High Very High
agonist 7 99.96 Very High Very High Very High
Neuropeptide 8 99.78 Very High Very High Very High
Analgesic 5 99.68 Very High Very High Very High
narcan 2 99.68 Very High Very High Very High
headache 1 99.00 Very High Very High Very High
Morphine 4 98.88 Very High Very High Very High
beta blocker 1 96.00 Very High Very High Very High
qutenza 4 94.36 High High
Disease Link Frequency Relevance Heat
Cancer 648 99.84 Very High Very High Very High
Dizziness 1 99.44 Very High Very High Very High
Pancreatic Cancer 147 99.12 Very High Very High Very High
Headache 1 99.00 Very High Very High Very High
Adenocarcinoma 77 98.68 Very High Very High Very High
Targeted Disruption 8 98.68 Very High Very High Very High
Metastasis 20 98.24 Very High Very High Very High
Hypertension 9 98.12 Very High Very High Very High
Infection 1 97.64 Very High Very High Very High
Cough 2 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The central effect of angiotensin II on the analgesic action of morphine in mice was investigated using the tail-pinch and hot plate tests.
Regulation (effect) of angiotensin II in tail associated with analgesic and morphine
1) Confidence 0.45 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 4080108 Disease Relevance 0.08 Pain Relevance 0.89
Antinociceptive effects of angiotensin-converting enzyme inhibitors and an angiotensin II receptor antagonist in mice.
Regulation (effects) of angiotensin II associated with antagonist and antinociceptive
2) Confidence 0.43 Published 1996 Journal Life Sci. Section Title Doc Link 8937511 Disease Relevance 0.10 Pain Relevance 0.49
Histochemical analysis indicated higher vascular density in AT2-KO mouse tumors than in wild type mouse tumors
Regulation (density) of AT2 associated with cancer
3) Confidence 0.31 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 2.23 Pain Relevance 0
In quantitative analysis, the percentage of Ki-67 positive cells is significantly higher in AT2-KO mouse tumors than in wild type mouse tumors (P ?
Regulation (higher) of AT2 associated with cancer
4) Confidence 0.31 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 1.57 Pain Relevance 0
Thus, it is suggested that the AT2 receptor could be an important target for cancer therapy/chemoprevention.


Regulation (target) of AT2 receptor associated with cancer
5) Confidence 0.21 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.71 Pain Relevance 0
We have previously demonstrated the pro-oncogenic role of the AT2 receptor in carcinogen-induced colon and lung tumorigenesis in the mouse.
Regulation (role) of AT2 receptor in lung
6) Confidence 0.21 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.51 Pain Relevance 0.06
These findings indicate that the AT2 receptor in stromal fibroblasts is a potentially important target for chemotherapy for pancreatic cancer.



Regulation (target) of AT2 receptor in fibroblasts associated with pancreatic cancer
7) Confidence 0.21 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2846883 Disease Relevance 0.77 Pain Relevance 0
To investigate the influence of the AT2 receptor on tumor growth, we inoculated PAN02 cells into both flanks of syngeneic AT2-KO (n = 6) and wild-type (n = 6) C57BL/6 mice.
Spec (investigate) Regulation (influence) of AT2 receptor associated with cancer
8) Confidence 0.21 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.43 Pain Relevance 0
The effects of mannitol and angiotensin II on the supraoptic MNCs in trpv1 knock-out mice were significantly attenuated compared with those in wild-type mice counterparts.
Regulation (effects) of angiotensin II in MNCs associated with targeted disruption
9) Confidence 0.18 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20089896 Disease Relevance 0.10 Pain Relevance 0.35
These results support an essential role of angiotensin II in TGF regulation mediated through the angiotensin II type 1A receptor.
Regulation (regulation) of angiotensin II
10) Confidence 0.10 Published 1999 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 10589702 Disease Relevance 0.68 Pain Relevance 0.17
We have previously demonstrated the pro-oncogenic role of the AT2 receptor in carcinogen-induced colon and lung tumorigenesis in the mouse.
Regulation (role) of AT2 receptor in colon
11) Confidence 0.07 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.51 Pain Relevance 0.06
Targeting the angiotensin II type 2 receptor (AT2R) in colorectal liver metastases

Background

Regulation (Targeting) of angiotensin II in liver associated with metastasis
12) Confidence 0.04 Published 2010 Journal Cancer Cell Int Section Title Doc Link PMC2902462 Disease Relevance 1.16 Pain Relevance 0.04
The degradative activity of NEP is not limited to neuropeptides, but also affects other significant peptides including angiotensin II and brakykinin (Katayama et al. 1991; Turner et al 1993; Yang et al 1997).
Regulation (affects) of angiotensin II associated with neuropeptide
13) Confidence 0.04 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 0.80 Pain Relevance 0.21
We have explored the possible antinociceptive effect of a CB2 receptor agonist, JWH133, using the formalin test in mice.
Spec (possible) Regulation (effect) of CB2 receptor associated with agonist and antinociceptive
14) Confidence 0.04 Published 2007 Journal Behav Pharmacol Section Abstract Doc Link 17912054 Disease Relevance 0.09 Pain Relevance 0.78
The adverse effects of AT-II-receptor antagonists--dizziness, headache, upper-respiratory-tract infection, cough, and gastrointestinal disturbances--occur at about the same rate as with placebo.
Regulation (effects) of AT-II-receptor in respiratory associated with antagonist, dizziness, cough, headache and infection
15) Confidence 0.01 Published 2000 Journal Am J Health Syst Pharm Section Abstract Doc Link 10902066 Disease Relevance 0.65 Pain Relevance 0.51

General Comments

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